Cognitive Behavioural Therapy and Applied Relaxation for Generalized Anxiety Disorder: A Time Series Analysis of Change in Worry and Somatic Anxiety

The present study examined symptom change profiles in patients with generalized anxiety disorder (GAD) receiving either cognitive behavioural therapy (CBT) or applied relaxation (AR). It was hypothesized that (a) changes in worry would uniquely predict changes in somatic anxiety for most participants receiving CBT and (b) changes in somatic anxiety would uniquely predict changes in worry for most participants in the AR condition. Twenty participants (CBT n = 10; AR n = 10) completed daily ratings of worry and somatic anxiety during therapy, and multivariate time series analysis was used to assess the causal impact of each variable on the other. The hypotheses were not supported because we found no evidence of a match between individual symptom change profiles and treatment condition. Rather, a bidirectional relationship between worry and somatic anxiety was observed in 80% of participants receiving CBT and 70% of participants receiving AR. When only treatment responders were considered, 83% of participants receiving CBT and 86% of those receiving AR had such a bidirectional effect. The findings are discussed in terms of models of psychopathology that posit dynamic interactions between symptom clusters and in terms of the value of examining treatment mechanisms at the individual level.     

An experimental study of the correlates and consequences of perceiving oneself to be the target of gender discrimination

An experimental methodology was used to test hypotheses concerning the effects of contextual, cognitive-developmental, and individual difference factors on children’s views of whether they have been the target of gender discrimination and the possible consequent effect of such views on two forms of state self-esteem: performance and social acceptance. Children (N = 108, 5-11 years of age) completed theory of mind and gender attitude measures and a drawing task. Next, children received feedback that was designed to appear either gender biased (discrimination condition) or nonbiased (control condition). Children’s attributions for the feedback and state self-esteem were assessed. As expected, children reported having been the target of gender discrimination more often in the discrimination condition than in the control condition. Older and more cognitively advanced children made fewer attributions to discrimination than their peers. Perceptions of discrimination were associated with higher performance state self-esteem and, among egalitarian children, lower social state self-esteem.     

The effect of reinforcement probability on time discrimination in the midsession reversal task

We examined how biasing time perception affects choice in a midsession reversal task. Given a simultaneous discrimination between stimuli S1 and S2, with choices of S1 reinforced during the first, but not the second half of the trials, and choices of S2 reinforced during the second, but not the first half of the trials, pigeons show anticipation errors (premature choices of S2) and perseveration errors (belated choices of S1). This suggests that choice depends on timing processes, on predicting when the contingency reverses based on session duration. We exposed 7 pigeons to a midsession reversal task and manipulated the reinforcement rate on each half of the session. Compared to equal reinforcement rates on both halves of the session, when the reinforcement rate on the first half was lower than on the second half, performance showed more anticipation and less perseveration errors, and when the reinforcement rate on the first half was higher than on the second half, performance showed a remarkable reduction of both types of errors. These results suggest that choice depends on both time into the session and the outcome of previous trials. They also challenge current models of timing to integrate local effects.     

阻断内侧前额叶皮质TrkB受体对大鼠认知和海马BDNF表达的影响

脑源性神经营养因子(brain-derived neurotrophic factor, BDNF)广泛参与了个体学习和记忆等认知功能, 通过与其酪氨酸激酶受体(tyrosine kinase, TrkB)特异性结合, 实现其多种神经生化功能。本研究观察了TrkB受体阻断剂ANA-12的慢性内侧前额叶皮质(medial prefrontal cortex, mPFC)注射对大鼠旷场行为、Morris水迷宫空间学习和逆反学习的影响。研究结果表明, mPFC的慢性BDNF阻断显著降低了大鼠在逆反学习测试中的逃离潜伏期和运动距离即增强了大鼠的逆反学习能力, 但不影响其旷场行为和水迷宫空间学习能力。同时, 慢性阻断mPFC-TrkB受体也并未导致大鼠海马BDNF蛋白含量的显著改变。这些结果提示, 对于大鼠的Morris水迷宫空间学习和逆反学习, mPFC-BDNF主要在逆反学习调节中发挥重要作用。这对于进一步探索海马和mPFC在调节个体认知功能中各自的作用及其潜在的相互关系提供了有力的证据和支持。     

Modeling dynamic inconsistency with a changing reference point

A rational principle of decision making called dynamic consistency was tested by presenting decision makers with a sequence of two gambles. The first gamble was obligatory. Before playing the first gamble, participants were asked to make a planned choice as to whether they would take the second gamble. After experiencing the actual results of the first gamble, decision makers were asked to make a final choice regarding the second gamble. Dynamic consistency requires agreement between the planned and final choices. Violations of dynamic consistency were observed, e.g. anticipating a gain in the first gamble, decision makers planned to take the second gamble; after experiencing the gain, they changed their minds and rejected the second gamble. Two models of dynamic inconsistency were compared. One assumes that experience shifts the reference point and changes the utility associated with the gamble; another assumes that experience changes the subjective probability associated with the gamble. The reference point model provided the best account for the findings. Copyright © 2003 John Wiley & Sons, Ltd.     

幼儿社交退缩游戏矫正的倒返实验研究

本研究采用A1B1A2B2的倒返实验设计,探讨由幼儿教师编制并实施的幼儿集体系列游戏是否能矫正幼儿的社交退缩。结果显示,被试在A1很少与人交往,在B1与人交往的时间经过一定的反复逐渐增加,在A2与人交往的时间再度减少,在B2与人交往的时间又增加;A1与B1、B2有极显著差别。实验证明,幼儿集体系列游戏可以矫正幼儿的问题行为。