Alertness in young healthy subjects: An fMRI study of brain region interactivity enhanced by a warning signal

An effective connectivity study was carried out on 16 young, healthy subjects performing an alertness task. The objective of this study was to develop and to evaluate a putative network model of alertness by adapting structural equation modeling to fMRI data. This study was designed to evaluate the directed interactivity of an attentional network during intrinsic and phasic alerting tasks. On the basis of theoretical hypotheses, clinical observations, behavioral data and neuroimaging studies, it was hypothesized that neural circuits in the right hemisphere including the dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex, inferior parietal cortex and the thalamus were involved. The results of this study support the existence of a common network of activated areas with significant path coefficient differences between intrinsic and phasic alertness. Functional interactivity was significantly reinforced during the phasic alertness task and appeared to preferentially involve activity in the DLPFC region, whereas the path coefficients of the model were well-balanced during intrinsic alertness. This study highlights the predominant role of the DLPFC region in maintenance of a state of alertness and in temporal preparation during an alertness task.     

Neural circuitry of the bilingual mental lexicon: Effect of age of second language acquisition

Numerous studies have proposed that changes of the human language faculty caused by neural maturation can explain the substantial differences in ultimate attainment of grammatical competences between first language (L1) acquirers and second language (L2) learners. However, little evidence on the effect of neural maturation on the attainment of lexical knowledge in L2 is available. The present functional magnetic resonance study addresses this question via a cross-linguistic neural adaptation paradigm. Age of acquisition (AoA) of L2 was systematically manipulated. Concrete nouns were repeated across language (e.g., French–German, valise^suitcase–Koffer^suitcase). Whereas early bilinguals (AoA of L2 < 3 years) showed larger repetition enhancement (RE) effects in the left superior temporal gyrus, the bilateral superior frontal gyrus and the right posterior insula, late bilinguals (AoA of L2 > 10 years) showed larger RE effects in the middle portion of the left insula and in the right middle frontal gyrus (MFG). We suggest that, as for grammatical knowledge, the attainment of lexical knowledge in L2 is affected by neural maturation. The present findings lend support to neurocognitive models of bilingual word recognition postulating that, for both early and late bilinguals, the two languages are interconnected at the conceptual level.     

脑成像在心理学研究领域的价值

现在普遍使用的脑成像技术给心理学研究增加了新的数据和资料。和任何新的方法一样,我们需要决定如何以适当的方式应用这项技术。这项技术如何以现有的方法所不能的方式帮助回答理论问题？这项技术最好是作为因变量还是作为预测变量来使用？它如何与其它感兴趣的心理变量相关？这种新的成像技术有助于我们了解大脑的运作及其与心理学的关系。研究人员需要弄清楚如何利用这项技术提供的信息加深对心理现象的理解。     

新颖词汇学习中大脑激活模式的fMRI研究

该研究利用功能磁共振脑成像(fMRI)技术,比较在新颖语言学习和母语学习过程中大脑皮层参与的异同。实验设置德语学习和汉语学习两个条件,采用跨通道联结学习范式,要求被试在听到听觉词汇后,按键判断屏幕上所呈现的图片是否与所听词汇匹配。行为数据显示,被试在六段实验后基本掌握了德语语音和语义之间的联结关系;脑成像数据显示,两种学习任务都激活了语言加工的主要脑区,而德语词汇学习过程相比汉语参照条件对应的颞叶激活强度与范围有较大的差异,并且比汉语条件表现出更显著的前额叶区域激活。     

Presurgical Language Mapping

ABSTRACT— Neurosurgical procedures for tumors or intractable epilepsy are often accompanied by risk to postoperative cognitive function; surgery in the left temporal or frontal lobes, for example, can place language functions at risk. Hence, prior to tissue extraction, one common surgical goal is to attempt to identify frontal and temporal regions that should be spared in order to preserve language function. We describe how basic research on false memory for word lists has led to a novel approach for identifying such language-related regions in healthy controls. That is, rapid presentation of semantically related words (e.g., bed , rest , awake ) and phonologically related words (e.g., peep , weep , heap ) with instructions to attend to relations among the words elicits activity in underlying language networks. Furthermore, it is often possible to identify the neural underpinnings of these networks in an individual person in about an hour of functional magnetic resonance imaging (fMRI) scanning. We conclude by suggesting directions for future research with this lexical-processing protocol, the overarching goal being to link basic cognitive science and clinical practice.     

Direct brain communication: neuroelectric and metabolic approaches at Tübingen

The brain–computer interface (BCI) provides users with the possibility of sending messages and commands to the external world without using their muscles, thus enabling communication to occur independent of movement. Such a possibility is of utmost importance for paralyzed patients who may otherwise lose their ability to communicate. Enhanced methodology and the development of faster computers have substantially improved applications and offer new possibilities in this field. To date, there have been over 20 BCI research groups working on different approaches. In this paper, we review our studies of BCI based on electric and metabolic activity of the brain.     

初级运动区的fMRI实验研究

本实验采用功能磁共振为实验仪器,被试进行运动准备和运动执行两种作业活动,实验设计为延时序列运动任务。在对实验数据进行预处理,反卷积、标准化处理后,采用欧式距离公式进行聚类统计,统计结果显示,M1区不仅具有运动执行和运动准备的功能,还发现其他功能区域的激活,不是单纯的运动执行功能,这一区域与三种活动有关。     

语言理解中语义整合的神经机制

语义整合是语言阅读理解中非常重要的环节。随着认知神经科学技术的广泛应用,当前关于语义整合的研究取得了长足进步,各种模型层出不穷。但是不同模型对于语义整合的功能定位及其内在机制却存在较大的争议。本文首先介绍当前关于语义整合的主要模型,然后对当前不同理论模型之间关于语义整合的界定,以及语义整合的功能定位是在额下回还是颞叶的争论进行了分析。我们认为,关于语义整合的实质、语义整合的功能网络将是未来研究的主要方向,相关的研究对于语言理解理论的发展将具有重要的启示。     

Guided saccades modulate face- and body-sensitive activation in the occipitotemporal cortex during social perception

Functional magnetic resonance imaging (fMRI) has identified distinct brain regions in ventral occipitotemporal cortex (VOTC) and lateral occipitotemporal cortex (LOTC) that are differentially activated by pictures of faces and bodies. Recent work from our laboratory has shown that the strong LOTC activation evoked by bodies in which the face is occluded is attenuated when the occlusion is removed. We hypothesized that this attenuation may occur because subjects preferentially fixate upon faces when present in the scene. Here, we experimentally manipulated subjects’ fixations while they viewed a static picture of a character whose face, hand, and torso were continuously visible throughout each run. The subject’s saccades and fixations were guided by a small fixation cross that made discrete jumps to a new location every 500 ms. Subjects were instructed to follow the fixation cross and make a button press whenever it changed size. In a series of blocks, the fixation cross shifted from locations on the face, on the hand, and to locations on a background image of a phase-scrambled face. In a second study, the fixation cross moved similarly, but the hand locations were changed to locations along the character’s body or torso. A localizer task was used to identify face- and body-sensitive regions of LOTC. Body-sensitive regions were strongly activated when the subjects’ saccades were guided over the character’s torso relative to when the saccades were guided over the character’s face. Little to no activity occurred in the body-sensitive region of LOTC when the subjects’ saccades were guided over the character’s hand. The localizer task was unable to differentiate body-sensitive regions in lateral VOTC from face-sensitive regions, or body-sensitive regions in medial VOTC from flower-sensitive regions. Guided saccades over the body strongly activated both lateral and medial VOTC. These results provide new insights into the function of body-sensitive visual areas in both LOTC and VOTC, and illustrate the potential confounding influence of uncontrolled eye movements for neuroimaging studies of social perception.     

Hemispheric asymmetries in semantic processing: evidence from false memories for ambiguous words

We used fMRI to investigate competition during language production in two word production tasks: object naming and color naming of achromatic line drawings. Generally, fMRI activation was higher for color naming. The line drawings were followed by a word (the distractor word) that referred to either the object, a related object, or an unrelated object. The effect of the distractor word on the BOLD response was qualitatively different for the two tasks. The activation pattern suggests two different kinds of competition during lexical retrieval: (1) Task-relevant responses (e.g., red in color naming) compete with task-irrelevant responses (i.e., the object’s name). This competition effect was dominant in prefrontal cortex. (2) Multiple task-relevant responses (i.e., target word and distractor word) compete for selection. This competition effect was dominant in ventral temporal cortex. This study provides further evidence for the distinct roles of frontal and temporal cortex in language production, while highlighting the effects of competition, albeit from different sources, in both regions.