Single case research results as clinical outcomes

The movement toward evidence-based treatments, interventions, or practices pressures single case research (SCR) to use statistical summaries which have broad credibility. These summaries also need to be easily understood and useful in schools and clinics. To date the effect size families, “proportion of variance” (R², Eta²) and “standardized mean difference” (Cohen's d, Hedges' g) have little popularity in SCR. This paper demonstrates a set of alternative Clinical Outcome indices widely used in the field of medicine: Risk Difference, Relative Risk, Relative Risk Improvement, and Odds Ratio, which compare patients in treatment versus control conditions. Translated to SCR designs, the baseline phase becomes the control condition, the intervention phase becomes the treatment condition, and improvement is defined as non-overlapping data between phases. The positive attributes of Clinical Outcomes are demonstrated: (a) easily interpretable results, (b) close relationship with concept of non-overlapping data, (c) minimal data assumptions, (d) minimal statistical expertise required, (e) multiple contrasts possible for diagnostic understanding, (f) exact confidence intervals for results, and (g) close relationship to Pearson R effect size family.     

Informed Consent in Emergency Research: A Contradiction in Terms

Improving the treatment of life threatening emergency illness or disease requires that new or novel therapies be assessed in clinical trials. As most subjects for these trials will be incapacitated there is some controversy about they might best protected whilst still allowing research to continue. Recent European and UK clinical trials legislation, which has effectively stopped research into emergency conditions, is discussed. Possible changes to these regulations are proposed.     

Following the Path to Equality Through Law: Reflections on Baker et al., <Emphasis Type="Italic">Equality: from Theory to Action</Emphasis>

This article assesses the significance of Baker et al., Equality: from Theory to Action from the perspective of current concerns occupying legal equality scholars in the UK, focusing in particular on the practical relevance of equality studies to the kinds of issues arising from the debate over the new Commission for Equality and Human Rights (CEHR). The article highlights and considers key issues, including the delineation of the sphere of inequality protection, the normative content of the concept of equality espoused by law and the potential of law to reach beyond its current limits to embrace the broader dimensions of (in)equality identified in Baker et al.’s account.     

Not Everything is Possible

This paper makes a point about the interpretation of the simplestquantified modal logic, that is, quantified modal logic witha single domain. It is commonly assumed that the domain in questionis to be understood as the set of all possibile objects. Thepoint of the paper is that this assumption is misguided.     

Effects of route guidance variable message signs (VMS) on driver behaviour

Effects of route guidance Variable Message Signs (VMS) on speed and route choice were investigated in a field study on two sites on motorways. Two VMS were used in the study, which displayed information about a closed road section downstream on the motorways and recommendations for alternative routes. Route choice, speed and braking behaviour were compared between vehicles approaching the VMS while they displayed messages and while they were left blank without message. There was high compliance with the messages on the VMS. About every fifth vehicle changed route choice according to the recommendation, and almost none drove as far as the closed road section. Speed measurements of 3342 vehicles showed large speed reductions, and video observations showed that large proportions of vehicles braked while approaching the VMS. The speed reductions and braking manoeuvres can partly be attributed to attention overload or distraction due to the information on the VMS. However, a proportion of the speed reductions was due to chain reactions where one vehicle braked and forced the following vehicles to brake or change lanes in order to avoid collisions. Safety problems may result directly from distraction, or indirectly from the reactions of the drivers to the distraction.     

错误相关负波（ERN）在精神病理学研究中的应用

错误相关负波（error-related negativity, ERN）是由行为错误诱发的一种脑电波成分,最大峰值在错误反应之后的50ms左右,偶极子源定位于前扣带回（anterior cingulate cortex, ACC）附近。错误加工（error processing）的经典研究范式中出现的ERN成分可能反映了ACC具有错误检测、冲突监控、强化学习、情绪动机等功能。大量研究表明过度的和不足的错误相关脑活动（hyperactive and hypoactive error processing）可能分别与精神病理学的内化性和外化性障碍（internalizing and externalizing disorders）相关联。内化性和外化性障碍的内表型（endophenotype）的研究,还存在许多值得进一步探索的问题。     

创伤后心理复原的生理机制

心理复原是个体在经历对生命具有威胁的事件或严重的创伤后仍然能回复到良好适应状况的现象。对心理复原生理机制的研究存在两种研究取向：或从个人能力的角度,或从发展结果的角度。创伤记忆的抑制、大脑的可塑性、神经生物的调节以及基因、气质、情绪调节、认知过程、早期经验等保护因子的影响机制是研究的主要内容。文章最后对今后的研究进行了展望     

保留的跨通道启动与老化：对于近期观点的总结

通道内重复启动的研究提示老年人内隐记忆未受损, 这不只体现在视觉通道上还包括其他感觉通道(例如触觉、听觉和嗅觉)。然而很少有研究考察启动任务是否具有通道特异性。在以年轻人为被试的研究中发现跨通道迁移(视觉到触觉和触觉到视觉)和通道内迁移(视觉到视觉, 触觉到触觉)具有相似性。一项最近的研究进一步探索老年人在跨通道启动任务上是否受损。结果显示视觉和触觉间的跨通道启动在年轻被试和老年被试上都是保留的且具有对称性。并且, 对于自然声响、图片的通道内和跨通道启动任务随着年老化发展仍旧保留。这些行为结果和其它最近神经科学结果显示跨通道启动发生于枕叶后纹状皮层区, 而这一区域在老年人中未损坏。这一领域未来的研究方向包括利用不同知觉通道间、利用熟悉的和新异的刺激并结合行为的和脑成像的方法, 通过设计完善的跨通道启动来研究正常老人与阿尔兹海默病人, 还包括将设计得完善的启动任务包括在用于改善老年人记忆功能的项目中。     

Translational behavior analysis: from laboratory science in stimulus control to intervention with persons with neurodevelopmental disabilities

Throughout its history, laboratory research in the experimental analysis of behavior has been successful in elucidating and clarifying basic learning principles and processes in both humans and nonhumans. In parallel, applied behavior analysis has shown how fundamental behavior-analytic principles and procedures can be employed to promote desirable forms of behavior and to prevent or ameliorate undesirable forms in clinical, educational, and other settings. Less obviously, there has also emerged a small but identifiable bridging field that can potentially connect and inform both basic and applied behavior analysis. Although such translational behavior analysis uses laboratory methodologies, research targets are selected largely for their value in ultimate application to improve the human condition. I will discuss the distinction of translational behavior analysis from basic and applied behavior analysis and consider the potential contribution that translational research can make in the development of the science of behavior.