论开展亲属活体供肾移植的风险与对策

肾脏移植是救治终末期肾功能衰竭的最佳手段。亲属活体捐献肾脏是扩大供肾来源的有效手段。当前国内开展亲属肾移植存在伦理、法律和健康风险,主要来自供体和医疗两方面。为防范风险,医务人员应严格审查供受者的血缘关系,签署完整规范的法律文书,进行全面细致的术前评估,制定完善的手术方案。     

Choice, time allocation, and response rate during stimulus generalization

Six pigeons were trained to discriminate between two noise intensities using a procedure that assessed choice, time allocation, and response rate simultaneously and independently. Responses on the left or right key (R1 or R2) were respectively correct in the presence of two different intensities, S1 and S2. After a correct response, reinforcement became available for pecks on the center key. Reinforcement density for R1¦S1 relative to R2¦S2 was varied across experimental conditions. Generalization tests followed extensive training at each condition. As a function of stimulus intensity, proportions of initial choices of R2, of time spent in R2-initiated components, and of center-key responses emitted in R2-initiated components all yielded sigmoidal gradients of similar slope, which shifted slightly in location when relative reinforcement density changed. Changeovers were maximal where initial choice proportions approximated 0.5. Gradients relating the absolute number of center-key responses to stimulus intensity were also roughly sigmoidal, but were more sensitive to changes in reinforcement density. Gradients of momentary response rate also depended on reinforcement density. During training, large but transitory shifts in choice responding occurred when reinforcement density changed, while differences in momentary response rate developed slowly, suggesting separate control of choice and response rate by the contingencies of reinforcement.     

Duration and rate of reinforcement as determinants of concurrent responding

The duration and frequency of food presentation were varied in concurrent variable-interval variable-interval schedules of reinforcement. In the first experiment, in which pigeons were exposed to a succession of eight different schedules, neither relative duration nor relative frequency of reinforcement had as great an effect on response distribution as they have when they are manipulated separately. These results supported those previously reported by Todorov (1973) and Schneider (1973). In a second experiment, each of seven pigeons was exposed to only one concurrent schedule in which the frequency and/or duration of reinforcement differed on the two keys. Under these conditions, each pigeon's relative rate of response closely matched the relative total access to food that each schedule provided. This result suggests that previous failures to obtain matching may be due to factors such as an insufficient length of exposure to each schedule or to the pigeons' repeated exposure to different concurrent schedules.     

Cue effectiveness in communicatively efficient discourse production

Recent years have seen a surge in accounts motivated by information theory that consider language production to be partially driven by a preference for communicative efficiency. Evidence from discourse production (i.e., production beyond the sentence level) has been argued to suggest that speakers distribute information across discourse so as to hold the conditional per-word entropy associated with each word constant, which would facilitate efficient information transfer (Genzel & Charniak, 2002). This hypothesis implies that the conditional (contextualized) probabilities of linguistic units affect speakers' preferences during production. Here, we extend this work in two ways. First, we explore how preceding cues are integrated into contextualized probabilities, a question which so far has received little to no attention. Specifically, we investigate how a cue's maximal informativity about upcoming words (the cue's effectiveness) decays as a function of the cue's recency. Based on properties of linguistic discourses as well as properties of human memory, we analytically derive a model of cue effectiveness decay and evaluate it against cross-linguistic data from 12 languages. Second, we relate the information theoretic accounts of discourse production to well-established mechanistic (activation-based) accounts: We relate contextualized probability distributions over words to their relative activation in a lexical network given preceding discourse.     

AGGRESSION AS POSITIVE REINFORCEMENT IN MICE UNDER VARIOUS RATIO‐ AND TIME‐BASED REINFORCEMENT SCHEDULES

There is evidence suggesting aggression may be a positive reinforcer in many species. However, only a few studies have examined the characteristics of aggression as a positive reinforcer in mice. Four types of reinforcement schedules were examined in the current experiment using male Swiss CFW albino mice in a resident—intruder model of aggression as a positive reinforcer. A nose poke response on an operant conditioning panel was reinforced under fixed‐ratio (FR 8), fixed‐interval (FI 5‐min), progressive ratio (PR 2), or differential reinforcement of low rate behavior reinforcement schedules (DRL 40‐s and DRL 80‐s). In the FR conditions, nose pokes were maintained by aggression and extinguished when the aggression contingency was removed. There were long postreinforcement pauses followed by bursts of responses with short interresponse times (IRTs). In the FI conditions, nose pokes were maintained by aggression, occurred more frequently as the interval elapsed, and extinguished when the contingency was removed. In the PR conditions, nose pokes were maintained by aggression, postreinforcement pauses increased as the ratio requirement increased, and responding was extinguished when the aggression contingency was removed. In the DRL conditions, the nose poke rate decreased, while the proportional distributions of IRTs and postreinforcement pauses shifted toward longer durations as the DRL interval increased. However, most responses occurred before the minimum IRT interval elapsed, suggesting weak temporal control of behavior. Overall, the findings suggest aggression can be a positive reinforcer for nose poke responses in mice on ratio‐ and time‐based reinforcement schedules.     

EFFECT OF REINFORCER MAGNITUDE ON PERFORMANCE MAINTAINED BY PROGRESSIVE‐RATIO SCHEDULES

This experiment examined the relationship between reinforcer magnitude and quantitative measures of performance on progressive‐ratio schedules. Fifteen rats were trained under a progressive‐ratio schedule in seven phases of the experiment in which the volume of a 0.6‐M sucrose solution reinforcer was varied within the range 6–300 μl. Overall response rates in successive ratios conformed to a bitonic equation derived from Killeen's (1994) Mathematical Principles of Reinforcement. The “specific activation” parameter, a, which is presumed to reflect the incentive value of the reinforcer, was a monotonically increasing function of reinforcer volume; the “response time” parameter, δ, which defines the minimum response time, increased as a function of reinforcer volume; the “currency” parameter, b, which is presumed to reflect the coupling of responses to the reinforcer, declined as a function of volume. Running response rate (response rate calculated after exclusion of the postreinforcement pause) decayed monotonically as a function of ratio size; the index of curvature of this function increased as a function of reinforcer volume. Postreinforcement pause increased as a function of ratio size. Estimates of a derived from overall response rates and postreinforcement pauses showed a modest positive correlation across conditions and between animals. Implications of the results for the quantification of reinforcer value and for the use of progressive‐ratio schedules in behavioral neuroscience are discussed.     

语言对知觉的影响—— 来自颜色范畴知觉研究的证据

介绍了近年来语言和颜色范畴知觉关系研究的新进展, 特别是颜色范畴知觉效应的偏侧化、婴幼儿颜色范畴知觉的特点等。同时指出了今后需要进一步研究的问题, 如颜色范畴知觉效应偏侧化与语言的关系、右脑语言优势者颜色范畴知觉的特点、颜色加工脑区和语言加工脑区之间的关系以及婴幼儿颜色范畴知觉特点的追踪研究等。     

Token reinforcement, choice, and self-control in pigeons.

Pigeons were exposed to self-control procedures that involved illumination of light-emitting diodes (LEDs) as a form of token reinforcement. In a discrete-trials arrangement, subjects chose between one and three LEDs; each LED was exchangeable for 2-s access to food during distinct posttrial exchange periods. In Experiment 1, subjects generally preferred the immediate presentation of a single LED over the delayed presentation of three LEDs, but differences in the delay to the exchange period between the two options prevented a clear assessment of the relative influence of LED delay and exchange-period delay as determinants of choice. In Experiment 2, in which delays to the exchange period from either alternative were equal in most conditions, all subjects preferred the delayed three LEDs more often than in Experiment-1. In Experiment 3, subjects preferred the option that resulted in a greater amount of food more often if the choices also produced LEDs than if they did not. In Experiment 4, preference for the delayed three LEDs was obtained when delays to the exchange period were equal, but reversed in favor of an immediate single LED when the latter choice also resulted in quicker access to exchange periods. The overall pattern of results suggests that (a) delay to the exchange period is a more critical determinant of choice than is delay to token presentation; (b) tokens may function as conditioned reinforcers, although their discriminative properties may be responsible for the self-control that occurs under token reinforcer arrangements; and (c) previously reported differences in the self-control choices of humans and pigeons may have resulted at least in part from the procedural conventions of using token reinforcers with human subjects and food reinforcers with pigeon subjects.     

THE USE OF BEHAVIORAL ASSESSMENT TO PRESCRIBE AND EVALUATE TREATMENTS FOR SEVERELY HANDICAPPED CHILDREN

Behavioral assessment procedures were used to prescribe and evaluate treatments of maladaptive behavior for 2 children with severe multiple handicaps. In Experiment 1, the results of an assessment of reinforcer preference were used in conjunction with a functional analysis of the conditions maintaining self-injurious behavior to prescribe a treatment for a child with severe disabilities. The treatment procedure involved the use of a pressure-sensitive microswitch to activate reinforcing stimuli during two solitary conditions, during which self-injurious behavior had occurred at high rates. The results were evaluated with a multiple baseline across settings design and indicated that self-injury decreased with concomitant increases in microswitch activation. Results were maintained at 6 weeks, 8 weeks, and 6 months. In Experiment 2, the results of behavioral assessments of reinforcer preference and self-injurious behavior were combined to develop a treatment for a second severely handicapped child, who exhibited high rates of self-injury in demand situations. This treatment was evaluated with a multiple baseline across tasks design and resulted in the elimination of self-injury for up to 15 months.     

Diminished heart rate complexity in adolescent girls: a sign of vulnerability to anxiety disorders?

Background and Objectives: Diminished heart rate variability has been found to be associated with high anxiety symptomatology. Since adolescence is the period of onset for many anxiety disorders, this study aimed to determine sex- and anxiety-related differences in heart rate variability and complexity in adolescents.

Methods: We created four groups according to sex and anxiety symptomatology: high-anxiety girls (n?=?24) and boys (n?=?25), and low-anxiety girls (n?=?22) and boys (n?=?24) and recorded their cardiac function while they performed regular school activities. A series of two-way (sex and anxiety) MANOVAs were performed on time domain variability, frequency domain variability, and non-linear complexity.

Results: We obtained no multivariate interaction effects between sex and anxiety, but highly anxious participants had lower heart rate variability than the low-anxiety group. Regarding sex, girls showed lower heart rate variability and complexity than boys.

Conclusions: The results suggest that adolescent girls have a less flexible cardiac system that could be a marker of the girls’ vulnerability to developing anxiety disorders.