氧化应激与动脉粥样硬化

活性氧是细胞内多种氧化还原反应的正常代谢产物,当活性氧的生成速率大于清除时,过多的活性氧会直接损伤细胞,还可通过信号转导系统引发一系列病理生理过程.各种氧化物前体可刺激血管细胞产生活性氧,加速动脉粥样硬化的形成和发展.他汀类、普罗布考等药物是目前最有希望的治疗冠状动脉粥样硬化性心脏病的抗氧化药物.     

主动性和反应性认知控制的权衡机制及影响因素

主动性控制和反应性控制是认知控制研究的新视角。前者通过在反应前维持目标相关信息的表征来预防冲突, 后者在反应时重激活目标相关信息以解决冲突。个体能够在这两种认知控制间进行权衡从而形成最优反应。通过AX-CPT等实验范式, 辅以ERP、fMRI技术可分离两种认知控制, 并观察到认知控制相关的脑区在激活时间和强度上的差异。个体生理发展、认知因素(期望、流体智力、训练)、非认知因素(情绪、动机等)均能影响认知控制的权衡。未来的研究应多关注这一权衡的内在神经机制和认知机制, 并与传统认知控制研究相结合, 在理论和应用上取得更进一步的发展。     

An application of the prototype willingness model to drivers' speeding behaviour

We tested the prototype willingness model (PWM). The participants (N = 198) completed online questionnaire measures of PWM constructs (Time 1) and subsequent speeding behaviour (Time 2). Path analyses showed that the PWM accounted for 89% of the variance in subsequent (self‐reported) speeding behaviour. This significantly exceeded the variance accounted for by the theory of planned behaviour. In line with the PWM, both behavioural intention and behavioural willingness had direct effects on behaviour. Behavioural willingness had a significantly larger effect. Attitude and subjective norm both had indirect effects on behaviour through both behavioural intention and behavioural willingness. Prototype (similarity) perceptions had indirect effects on behaviour through behavioural willingness only. The findings support the notion that driving is governed by reactive decision‐making (willingness), underpinned by prototype perceptions, attitudes and subjective norms, to a greater extent than it is deliberative decision‐making (intentions), underpinned by attitudes and subjective norms. The implications for safety interventions are discussed.     

Mothers' Reactions to Preschoolers' Proactive and Reactive Aggressive Behaviours

The present study was designed to examine mothers' emotional reactions, causal attributions, and socialization strategies in response to preschool children's engagement in proactive and reactive physical aggression with peers during free play at school. Participants were 84 mothers (M_age = 31.83, SD = 4.48) with preschool‐aged children (M_age = 4.92, SD = 0. 97), residing in Ankara, Turkey. Supporting our expectations, mothers reacted with negative emotions to both functions of aggressive behaviours, with less anxiety, disappointment, embarrassment, and guilt for reactive aggression. They also believed that reactive aggression is more contextually dependent and intentional and reported more indirect (e.g., asking the child, teacher, or other children to find out more about the situation and aggressive episode) and other‐oriented strategies (e.g., telling the other child to behave properly) to address these behaviours. Overall, our findings suggest that Turkish mothers' feelings, perceptions, and socialization approaches to childhood aggression vary depending on the functions of aggression, and mothers perceive preschool‐aged children's engagement in reactive aggression in the school setting as relatively more acceptable than proactive aggression. Copyright © 2016 John Wiley & Sons, Ltd.     

The reactive–proactive aggression questionnaire: differential correlates of reactive and proactive aggression in adolescent boys

This study reports the development of the Reactive–Proactive Aggression Questionnaire (RPQ), and the differential correlates of these two forms of aggression. Antisocial, psychosocial and personality measures were obtained at ages 7 and 16 years in schoolboys, while the RPQ was administered to 334 of the boys at age 16 years. Confirmatory factor analysis indicated a significant fit for a two‐factor proactive–reactive model that replicated from one independent subsample to another. Proactive aggression was uniquely characterized at age 7 by initiation of fights, strong‐arm tactics, delinquency, poor school motivation, poor peer relationships, single‐parent status, psychosocial adversity, substance‐abusing parents, and hyperactivity, and at age 16 by a psychopathic personality, blunted affect, delinquency, and serious violent offending. Reactive aggression was uniquely characterized at age 16 by impulsivity, hostility, social anxiety, lack of close friends, unusual perceptual experiences, and ideas of reference. Findings confirm and extend the differential correlates of proactive–reactive aggression, and demonstrate that this brief but reliable and valid self‐report instrument can be used to assess proactive and reactive aggression in child and adolescent samples. Aggr. Behav. 32:159–171, 2006. © 2006 Wiley‐Liss, Inc.     

Proactive and reactive aggression among school bullies,victims, and bully‐victims

Bullies, victims, bully‐victims, and control children were identified from a sample of 1062 children (530 girls and 532 boys), aged 10 to 12 years, participating in the study. Their reactive and proactive aggression was measured by means of peer and teacher reports. Peer and teacher reports were more concordant with respect to reactive than proactive aggression. Comparing the children in different bullying roles in terms of their reactive and proactive aggression, bully‐victims were found to be the most aggressive group of all. For this group, it was typical to be highly aggressive both reactively and proactively. Although bullies were significantly less aggressive than bully‐victims, they scored higher than victims and controls on both reactive and proactive aggression. However, observations at the person level, i.e., cross‐tabulational analyses, indicated that bullies were not only overrepresented among children who were both reactively and procatively aggressive but also among the only reactively aggressive as well as the only proactively aggressive groups. Victims scored higher than control children on reactive aggression, but they were not proactively aggressive. Furthermore, even their reactive aggression was at a significantly lower level than that of bullies and bully‐victims. Aggr. Behav. 28:30–44, 2002. © 2002 Wiley‐Liss, Inc.     

攻击动机对特质愤怒与反应性攻击关系的中介作用：一项纵向研究

特质愤怒是影响反应性攻击的重要人格因素, 反应性攻击的提出是基于攻击动机, 但是特质愤怒影响反应性攻击的动机机制尚不清楚。本研究假设特质愤怒可以通过增强反应性攻击的特异性动机(即敌意性动机)以及反应性攻击与主动性攻击的共同性动机(即道德准许动机)来纵向预测反应性攻击。为了检验该假设, 对5个省市共1007名大学生的特质愤怒、敌意归因偏向(代表敌意性动机)和道德推脱(代表道德准许动机)、反应性攻击与主动性攻击进行了3次追踪调查。结果显示：(1)在控制性别后, 第一个时间点的特质愤怒可以通过第二个时间点的敌意归因偏向和道德推脱预测第三个时间点的反应性攻击; (2)敌意归因偏向只能纵向预测反应性攻击, 而不能跨时间预测主动性攻击; (3)道德推脱可以纵向预测反应性攻击和主动性攻击。这一结果支持了特质愤怒影响反应性攻击的动机模型, 发展了人格与攻击关系的理论与研究, 对于揭示反应性攻击形成的动机机制具有积极作用。