What Are We Doing When We Translate from Quantitative Models?

Although quantitative analysis (in which behavior principles are defined in terms of equations) has become common in basic behavior analysis, translational efforts often examine everyday events through the lens of narrative versions of laboratory-derived principles. This approach to translation, although useful, is incomplete because equations may convey concepts that are difficult to capture in words. To support this point, we provide a nontechnical introduction to selected aspects of quantitative analysis; consider some issues that translational investigators (and, potentially, practitioners) confront when attempting to translate from quantitative models; and discuss examples of relevant translational studies. We conclude that, where behavior-science translation is concerned, the quantitative features of quantitative models cannot be ignored without sacrificing conceptual precision, scientific and practical insights, and the capacity of the basic and applied wings of behavior analysis to communicate effectively.     

联合常规细胞遗传学技术、多重巢式聚合酶链反应技术检测120例急性白血病患者遗传学异常

探讨如何提高急性白血病患者染色体／特异融合基因异常的检出率与准确率。联合常规细胞遗传学技术、多重巢式聚合酶链反应技术对120例急性白血病患者进行检测。结果表明：应用常规细胞遗传学检测出82例核型异常,占68．3％,而应用多重巢式聚合酶链反应技术检测出54例融合基因异常,占45％。联合这两种技术,120例急性白血病患者的遗传学异常检出率为：75％（90／120）,其中有65例明确了具体染色体改变或特异性融合基因异常。30例患者经常规细胞遗传学检测出具有t（8;21）（q22;q22）或t（15;17）（q22;q12）,多重巢式聚合酶链反应技术检测出39例患者具有AML1／ETO、PML／RARA或CBFB／MYH11融合基因异常。当存在染色体数目异常,或者不存在19种融合基因之一时多重巢式聚合酶链反应结果为阴性。提示常规细胞遗传学技术联合多重巢式聚合酶链反应技术可以有效地提高急性白血病患者染色体异常／特异性融合基因的检出率。     

脂多糖受体mCD14定量研究的方法探讨

本文通过横断面研究,时100例正常人群（一次性）采集外周全血2ml,选用流式细胞技术测定单核细胞群、mCD14平均荧光强度值,行盲法测定。观察正常人群外周血mCD14的表达水平,探讨正常人群mCD14定量研究的方法。结果显示单核细胞与淋巴细胞的比值比单个读取mCD14的平均荧光强度值更具可重复性,集中趋势较好,有利于临床应用和比较研究。此方法可作为流式细胞仪定量检测数据校正的方法参考。     

The embodied self: thinking psychoanalytically in a time of 'science'

Abstract :  In order to be relevant in our 'scientific' times, it is necessary that we psychoanalysts situate our ideas in thoughtful and respectful relationship to neighbouring disciplines such as genetics, cultural studies, and neuro-anatomy. In this paper I suggest that, although psychoanalysis still continues to have valuable contributions to make to the understanding of human sexual experience and behaviour, in order to make these contributions relevant we must tune in with openness to the challenges posed by the unfolding discoveries in the other disciplines that grapple with the arena of human sexuality.
I will suggest ways in which research on sexual desire and gender identity may be assimilated into psychoanalytic thinking and give some examples of its use in analytic practice.     

成人学习不良的神经心理与行为遗传研究

介绍了成人学习不良者神经心理与行为遗传方面的研究,深入分析了成人学习不良中阅读不良的电生理和行为遗传特点,并简要总结了有关数学不良的神经心理与行为遗传的相关机制。     

数量化维度特征搜索的影响因素探索

有关数量化维度特征搜索的研究表明 ,目标搜索斜率 (反应时间对呈现项目数量函数的斜率 )是由目标与干扰子之间的差异决定的 ,然而以往研究中其差异的值取决于具体的实验条件。根据韦伯定律 ,笔者推测 ,目标搜索斜率应由目标与干扰子之间的相对差异 (C)决定 ,C为目标值 (T)与干扰子值 (D)的差值与该干扰子值的比值。当C值对应相等时 ,不同几何形状刺激的目标搜索斜率应无差异。为此笔者分别采用圆 (实验一 )和三角形 (实验二 )进行实验研究。实验结果支持了上述假设 ,并发现目标大于干扰子时的目标搜索斜率对C值的函数是单调递减函数     

On the heritability of inspection time and its covariance with IQ: a twin study

Using the classical twin design, this study investigates the influence of genetic factors on the large phenotypic variance in inspection time (IT), and whether the well established IT–IQ association can be explained by a common genetic factor. Three hundred ninety pairs of twins (184 monozygotic, MZ; 206 dizygotic, DZ) with a mean age of 16 years participated, and 49 pairs returned approximately 3 months later for retesting. As in many IT studies, the pi figure stimulus was used and IT was estimated from the cumulative normal ogive. IT ranged from 39.4 to 774.1 ms (159±110.1 ms) with faster ITs (by an average of 26.9 ms) found in the retest session from which a reliability of .69 was estimated. Full-scale IQ (FIQ) was assessed by the Multidimensional Aptitude Battery (MAB) and ranged from 79 to 145 (111±13). The phenotypic association between IT and FIQ was confirmed (−.35) and bivariate results showed that a common genetic factor accounted for 36% of the variance in IT and 32% of the variance in FIQ. The maximum likelihood estimate of the genetic correlation was −.63. When performance and verbal IQ (PIQ & VIQ) were analysed with IT, a stronger phenotypic and genetic relationship was found between PIQ and IT than with VIQ. A large part of the IT variance (64%) was accounted for by a unique environmental factor. Further genetic factors were needed to explain the remaining variance in IQ with a small component of unique environmental variance present. The separability of a shared genetic factor influencing IT and IQ from the total genetic variance in IQ suggests that IT affects a specific subcomponent of intelligence rather than a generalised efficiency.     

糖皮质激素对骨作用的量变与质变

糖皮质激素是人体内分泌的一类激素,正常人血液中的糖皮质激素应保持在一定的范围内,如果体内糖皮质激素的浓度长期高于此范围就会产生副作用,骨质疏松症就是其中之一。所以在使用糖皮质激素时应保持一定的度,使其变化在量变的范围内,预防糖皮质激素诱导的骨质疏松症的发生。     

On the falsifiability of matching theory.

Herrnstein's matching theory requires the parameter, k, which appears in the single-alternative form of the matching equation, to remain invariant with respect to changes in reinforcement parameters like magnitude or immediacy. Recent experiments have disconfirmed matching theory by showing that the invariant-k requirement does not hold. However, the theory can be asserted in a purely algebraic form that does not require an invariant k and that is not disconfirmed by the recent findings. In addition, both the original and the purely algebraic versions of matching theory can be asserted in forms that allow for commonly observed deviations from matching (bias, undermatching, and overmatching). The recent finding of a variable k does not disconfirm these versions of matching theory either. As a consequence, matching remains a viable theory of behavior, the strength of which lies in its general conceptualization of all behavior as choice, and in its unified mathematical treatment of single- and multialternative environments.     

Germ-line gene therapy and the clinical ethos of medical genetics

Although the ability to perform gene therapy in human germ-line cells is still hypothetical, the rate of progress in molecular and cell biology suggests that it will only be a matter of time before reliable clinical techniques will be within reach. Three sets of arguments are commonly advanced against developing those techniques, respectively pointing to the clinical risks, social dangers and better alternatives. In this paper we analyze those arguments from the perspective of the client-centered ethos that traditionally governs practice in medical genetics. This perspective clarifies the merits of these arguments for geneticists, and suggests useful new directions for the professional discussion of germ-line gene therapy. It suggests, for example, that the much discussed prospect of germ-line therapy in human pre-embryos may always be more problematic for medical genetics than adult germ-line interventions, even though the latter faces greater technical difficulties.