Genes and human behavior: the emerging paradigm

The physical properties of human beings and other organisms as well as their social behavioral traits are manifestations of both genetic inheritance and environment. Recent behavioral research has indicated that certain characteristics or behaviors—such as schizophrenia, divorce, and homosexuality—are highly heritable and are not governed exclusively by social environment. A balanced view of human behavior includes the effects of social learning as well as of genetically determined behavior. A new paradigm promotes enhanced understanding and acceptance of human diversity, be it cultural, racial, or sexual, and has the potential to unite scientists and theologians by creating common grounds of understanding.     

The relationship between qualitative and quantitative research: Lessons from feminist psychology

The dominant methodological approach in psychological research has involved the use of quantitative methods within a positivist framework. In this article we argue that both qualitative and quantitative methods have their strengths and limitations, depending on the research question under investigation. We examine some of the advantages of qualitative methods, paying particular attention to the value of such methods for feminist researchers. We challenge the positivist assumption that all research should be apolitical and value-free, arguing that the political context in which all research studies take place plays an important role in decisions about the appropriate research methods to use. Despite the value attached to qualitative methods by feminist researchers, there may be projects for which quantitative methods, or a combination of qualitative and quantitative techniques, are more suitable. We draw on examples from our research on the transition from school to the job market for young people, and a study of 16- to 19-year-old first time mothers to illustrate these points, examining the practical implications of our arguments for applied social psychology research.     

Synapses,Schizophrenia, and Civilization: What Made Homo Sapient?

Progress in technology has allowed dynamic research on the development of the human brain that has revolutionized concepts. Particularly, the notions of plasticity, neuronal selection, and the effects of afferent stimuli have entered into thinking about brain development. Here I focus on development from the age of four years to early adulthood, during which a 30 percent reduction in some brain synapses occurs that is out of proportion to changes in neuronal numbers. This corresponds temporally with changes in normal child behavior from the loose‐associative, almost schizoid, thinking and art of the four‐year‐old to the more trained, or disciplined, or acculturated—and restrained—personality of the young adult. I propose that the synaptic changes can best be thought of as a winnowing process likely subject to environmental influences. Acquisition of language and the ability to link linguistic cognition to the plastic development of the brain provide a potentially powerful means of explaining the evolutionally explosive development of human cognition and culture. Schizophrenia, a disease that can be envisioned as representing a derangement of synaptic maturation, may provide an entry into the search for genes controlling the processes mediating the unprecedented development of Homo sapiens over the past 40,000 to 70,000 years. The recently completed mapping of the genome of the chimpanzee provides a new frame of reference that may speed the search.     

EDITORIAL Building bridges with mixed methods research?

Mixed methods refers to the use of both qualitative and quantitative approaches and methods in one study or sequentially in two or more studies. Without a mixed methods approach there is – to our minds ‐ a risk that only part of a phenomenon or experience is being explored. Our own involvement in mixed methods research has grown out of a shared interest in the concept ‘research‐practitioner’. Psychotherapy is a notoriously complex and ever‐developing field, and our growing sense has been that mixed methods research can contribute to a more complete – both broad and deep ‐ sense of knowledge and understanding.     

Inherited and Environmental Moderators of Mother-Child Behavioral Contingency and Contingent Negativity at 27 Months

Previous research has shown that as depressive symptomology increases, mothers tend to show withdrawn or harsh interaction patterns with their children, and the quality of these interaction patterns have subsequently been linked to child behavior problems. However, little research has examined bidirectional influences between mothers and their children, and how these moment-to-moment contingencies differ based on heritable and environmental characteristics. We used data from the Early Growth and Development Study a prospective adoption study to examine how adoptive mothers’ depressive symptoms and children’s heritable tendencies for negative affectivity interact to predict the quality of mother-child interactions at child age 27-months. Results detected two distinct dyadic interaction patterns. The first was a withdrawn interaction style and was observed in children with a high heritable tendency for negative affect. In that style, mother and child interactions were not contingent upon each other, suggesting a lack of joint engagement. The second was a volatile interaction style, observed in children with a low heritable tendency for negative affect. In these cases, mother and child interactions were highly contingent but negative. Our findings demonstrate essential differences in how dyadic interaction patterns vary according to level of depressive symptomology and heritable tendency for negative affect.     

耐挫心理结构的探索：基于大学生群体的测量

采用质性和量化研究方法,探讨耐挫心理的结构及因素间关系。研究1采用质性研究方法,对23名被试进行深度访谈,结果发现：（1）耐挫心理的结构由坚信、乐观、可控和醒悟构成;（2）坚信、可控和醒悟共同影响乐观。研究2采用量化研究方法,基于研究1的耐挫心理结构编制大学生耐挫心理量表,对大学生进行施测。结果发现：（1）耐挫心理四因素结构有良好的拟合指数;（2）醒悟正向预测坚信,进而正向预测可控,最终正向预测乐观;（3）量表有良好的信度和效度。结果表明,耐挫心理的结构包含坚信、乐观、可控和醒悟四个因素;大学生耐挫心理量表符合心理测量学要求,可作为未来研究的工具。     

Hyperactivity in Children: A Focus on Genetic Research and Psychological Theories

Hyperactivity has attracted a large amount of research interest in recent years. Here we review developments in genetic research and in research testing psychological theories of the condition. Family, adoptee and twin studies indicate a strong role for genetic factors in the etiology of hyperactivity. Evidence is emerging also from molecular genetic studies, implicating specific genes that may be involved. At the level of cognitive functioning, a divided, focused or sustained attention deficit does not seem to be a core deficit in hyperactivity. Although children with hyperactivity often perform poorly on certain executive function tasks, there is disagreement about the interpretation of these findings. The association reported in some studies between a slow inhibitory process and hyperactivity may reflect a generally slow, variable in speed and inaccurate pattern of responding. Hypotheses about psychological mechanisms such as state regulation or delay aversion provide alternative, and particularly encouraging, interpretations of the findings. We discuss the possible integration of the two lines of research—those of genetic research and research on psychological mechanisms.     

Differential acquisition of lever pressing in inbred and outbred mice: comparison of one-lever and two-lever procedures and correlation with differences in locomotor activity

Recent progress in mouse genetics has led to an increased interest in developing procedures for assessing mouse behavior, but relatively few of the behavioral procedures developed involve positively reinforced operant behavior. When operant methods are used, nose poking, not lever pressing, is the target response. In the current study differential acquisition of milk-reinforced lever pressing was observed in five inbred strains (C57BL/6J, DBA/2J, 129X1/SvJ, C3H/HeJ, and BALB/cJ) and one outbred stock (CD-1) of mice. Regardless of whether one or two levers (an "operative" and "inoperative" lever) were in the operant chamber, a concomitant variable-time fixed-ratio schedule of milk reinforcement established lever pressing in the majority of mice within two 120-min sessions. Substantial differences in lever pressing were observed across mice and between procedures. Adding an inoperative lever retarded acquisition in C57BL/6J, DBA/2J, 129X1/SvJ, and C3H/HeJ mice, but not in CD-1 and BALB/cJ mice. Locomotor activity was positively correlated with number of lever presses in both procedures. Analyses of durations of the subcomponents (e.g., time to move from hopper to lever) of operant behavior revealed further differences among the six types of mice. Together, the data suggest that appetitively reinforced lever pressing can be acquired rapidly in mice and that a combination of procedural, behavioral, and genetic variables contributes to this acquisition.     

The Nature and Significance of Behavioural Genetic Information

In light of the human genome project, establishing the genetic aetiology of complex human diseases has become a research priority within Western medicine. However, in addition to the identification of disease genes, numerous research projects are also being undertaken to identify genes contributing to the development of human behavioural characteristics, such as cognitive ability and criminal tendency. The permissibility of this research is obviously controversial: will society benefit from this research, or will it adversely affect our conceptions of ourselves and each other? When assessing the permissibility of this research, it is important to consider the nature and deterministic significance of behavioural genetic information. Whilst todate there has been much discussion and debate about the properties of genetic information per se and genetic determinism, this has not been applied to behavioural genetic research and its ethical implications. Therefore, this paper elucidates how behavioural genetic information can be distinguished from other types of genetic and non-genetic information and also synthesises the determinative significance of genetic factors for the development of human behavioural traits. Undertaking this analysis enables the ethical issues raised by this research to be debated in an appropriate context and indicates that separate policy considerations are warranted.

     

Metaphors in behavioral genetics

Behavioral geneticists sometimes use metaphorsto describe the role of genes in humanbehavior. In this paper, five sample texts areanalyzed: a popular book, a textbook, ascientific review article, and two originalscientific articles representing differentapproaches in behavioral genetics. Metaphorsare found in all the different kinds of sampletexts, not only in the popular book and thetextbook. This suggests that metaphors are usednot only for rhetorical or pedagogical purposesbut play a more fundamental role in scientificunderstanding. In the sample texts, themetaphors tend to be antideterministic, i.e.,they do not imply genetic determinism butstress the interaction of multiple genes andmultiple environmental factors. No conclusioncan be drawn, however, as to whetherantideterminism is representative ofpresent-day behavioral geneticists in general.Certain historically important metaphors thatmay imply genetic determinism are qualified,avoided, or explicitly rejected. There aretensions between some of the metaphors, makingthem difficult to combine. All the metaphorsthat are used appear empirically apt, howeversometimes only with certain qualifications.