从高血压的新定义分析难治性高血压

ASH公布了高血压新的定义,其中高血压的过度反应需与真性难治性高血压鉴别,从三个层面分析难治性高血压。     

高血压脑出血急诊救治现状与进展

高血压脑出血是指在高血压的情况下发生的脑实质内出血。目前急诊综合救治中内科药物和外科手术治疗为主要的两种方法。内科治疗只适用于轻度脑出血和有手术禁忌证及配合急诊外科手术的综合救治,外科手术多用在中、重度脑出血病人治疗中。近年来开展的一种在CT下三维定位脑内血肿清除术,以其定位准确,脑损伤小,在急诊救治方面取得了一定效果,有待于进一步发展。     

动脉功能评价与降压质量

高血压的治疗中降压是最重要的原则,降压达标可以带来心血管事件的下降已是不争的事实。流行病学调查证实动脉功能是心血管事件的独立预测因子。动脉功能的评价不仅可以筛查高危人群,还可作为降压质量评价的指标,临床研究已证实其意义。未来的高血压治疗领域,除监测血压外,可能需要监测和评估动脉功能。     

关注降压药物的选择，促使更有效的降压达标

我国成人高血压患病率高达18.8%,全国有高血压患者约1.6亿。合理的药物治疗是降压达标的主要措施,如何进行正确选择成为摆在我们面前的难题。目前,降压药物主要包括利尿剂、β受体阻断剂、血管紧张素转换酶抑制剂、血管紧张素Ⅱ受体拮抗剂、钙拮抗剂和α受体阻断剂6类。因降压治疗的收益主要来自于降压本身,为了提高降压达标率及高血压患者的用药依从性,目前多主张低剂量联合治疗。     

医师知识结构和思维方式与肺血栓栓塞症诊断

肺血栓栓塞症是常见的临床病症,因其临床表现多样,易发生误诊漏诊而导致较高的病死率。但“凡事预则立,不预则废”,充分掌握肺血栓栓塞症的知识、以正确的思维方式引导临床诊疗可以有效减少和避免误诊漏诊。     

单纯性肾囊肿外科手术适应证的选择

单纯性肾囊肿是临床常见的肾脏疾病之一,临床常采用去顶减压术治疗,但外科治疗的适应证目前尚不统一。除症状性肾囊肿及由囊肿引起尿路梗阻外,对于高血压病合并肾囊肿者,如囊肿直径大于5cm,考虑囊肿有可能对高血压产生影响,因此,有必要采取外科治疗措施;但如果不合并高血压,是否一定需要治疗有待进一步探讨。肾囊肿对肾功能影响目前尚无定论,对于小于60岁的肾囊肿患者其肾功能下降可能与肾脏原发病变有关,应积极查找病因并密切随访。对于肾囊肿Bosniak分型为Ⅰ、Ⅱ、ⅡF型的患者,可以不需要手术治疗,密切随访;对于Ⅲ、Ⅳ型患者,应进行外科手术治疗。     

Hypertension and cognitive function

Previous research indicates that blood pressure may impact a variety of cognitive functions, including short-term memory, abstract reasoning, visual-spatial abilities, and attention (Boller, Vrtunski, Mack, & Kim, 1977; Elias, Robbins, Schultz, & Pierce, 1990; Franceschi, Tancredi, Smirne, Mercinelli, & Canal, 1982; Mazzucchiet al., 1986). However, studies which have assessed the cognitive functioning of hypertensive adults have offered conflicting results, particularly when hypertension levels were in the mild range (e.g., Bolleret al., 1977; Eliaset al., 1990; Elias, Wolf, D'Agostino, Cobb, & White, 1993; Farmeret al., 1987, 1990; Franceschiet al., 1982; Pérez-Stable, Coates, Halliday, Gardiner, & Hauck, 1992; Schmidtet al., 1991; Waldstein, Ryan, Manuck, Parkinson, & Bromet, 1991). A number of factors may contribute to the inconsistent findings in this area. Researchers have employed a wide range of neuropsychological instruments to assess varying domains of cognitive function. Sample sizes in some studies have been too small to ensure sufficient power. Finally, studies have employed varying methodological control over potential confounding factors such as concurrent medical conditions, alcohol abuse, psychiatric disorders, or antihypertensive medication. This study compared male veterans with blood pressures in the mildly hypertensive range (n=166) to normotensive veterans (n=176) on neuropsychological measures of verbal fluency, visual-spatial ability, verbal and visual memory, dexterity, attention, and executive functions. Results revealed that, after controlling for differences in education and income, there was no relationship between mild hypertension and combined measures of cognitive performance. The present findings suggest that mild hypertension alone has little effect on cognitive function in adults.     

The relaxation word of the day: A simple technique to measure adherence to relaxation

A new procedure of assessing adherence to home practice of relaxation is presented. The technique involved the subject identifying one of four possible relaxation words of the day at the end of a taped relaxation session. The method was employed to assess the relationship between adherence to relaxation and decline of blood pressure during a 10-session/8-week relaxation program involving 17 hypertensive subjects. No statistically significant relationship was found on either a short-term or a long-term basis. An advantage of the assessment technique is that it appears easily integrated into the overall therapeutic objective for relaxation therapy; a disadvantage is that the subject needs to comply not only with the relaxation schedule but also with the monitoring procedure.This research study was funded by NIH Grant HL27159.     

高血压患者应激反应特点及行为人格的关系研究

为了解高血压患者心血管反应的特征及与健康人群的差异,使用实验和问卷调查的方法对高血压患者和健康居民进行研究。结果显示,两组在任务期和恢复期的心血管反应差异显著（P〈0．05）;病例组的健康实践行为和消极应对方式水平较高,积极应对方式有待提升;健康实践行为和恢复期舒张压呈负相关,积极应对方式和任务期收缩压呈正相关（P〈0...     

控制论的目的论思想与高血压病诊治

20世纪中叶以来,随着控制论的兴起与广泛应用,目的论问题成为生物学哲学以及系统科学哲学的重要议题。运用控制论原理及其目的论思想对高血压病诊治中的有关问题进行了分析和探索,以期对高血压病做到更有效的控制。