老年高血压患者降压治疗中的低血压原因分析及对策

老年高血压患者降压治疗中可能并发低血压,原因为假性高血压、体位性低血压,餐后低血压,季节变化、伴随疾病和不适当用药引起的低血压.低血压可导致心脑肾等重要脏器灌注不足,甚至发生脑卒中、心肌梗死等严重并发症.因此,及时发现老年高血压患者治疗中的低血压,给予相应治疗已显得十分重要.     

以高血压治疗为例谈以患者为中心的医疗模式

高血压是我国心脑血管病致死的主要危险因素,我国高血压的发病率仍在不断增高.但近年高血压的“知晓率,治疗率和达标率”改变仍不明显.在大量的临床工作中,由于患者多,工作繁忙等原因,医生在日常工作中,与患者没有机会交流,对高血压患者的处理,只限于开药,并不能与患者进行健康生活方式的指导,更缺乏心理交流.因此,对高血压患者的治疗,并不能得到很好的治疗依从性,影响治疗效果.本文根据本人的一点临床工作经验,提出必须重视与患者的交流,加强对患者不良生活方式的纠正,积极鼓励戒烟,降低钠盐摄入等综合防治措施,力争达到较好的高血压治疗效果.     

阻塞性睡眠呼吸暂停低通气综合征导致高血压的机制

阻塞性睡眠呼吸暂停低通气综合征是重要的继发性高血压病因之一,该综合征导致血压增高的原因主要有睡眠分裂、频繁的低氧血症和高碳酸血症导致的高交感神经兴奋,呼吸暂停发生时胸腔负压的增加和回心血量的增加以及内分泌功能的失调如醛固酮的高分泌,超重肥胖和慢性非特异性炎症反应的参与,是多种升压机制共同参与的结果.     

Prediction of end-of-life fears in COPD – hoping for the best but preparing for the worst

Objective: The diagnosis of a life-threatening illness can trigger end-of-life fears. Early studies show that end-of-life fears play an important role in chronic obstructive pulmonary disease (COPD). However, predictors of these fears have not yet been identified. This study investigated the relevance of socio-demographic variables, illness severity, psychological distress and disease-specific anxieties as predictors of end-of-life fears in COPD.

Design: A total of 131 COPD patients participated at two time points. Regression and mediation analyses, as well as cross-lagged panel analyses were conducted.

Main outcome measures: The participants completed questionnaires assessing end-of-life fears (Multidimensional Orientation toward Dying and Death Inventory), psychological distress (Hospital Anxiety and Depression Scale), and disease-specific anxieties (COPD Anxiety Questionnaire). Pulmonary function and a 6-min walk test served as measures of illness severity.

Results: Illness severity was not predictive of end-of-life fears. However, gender and psychological distress explained incremental variance. When disease-specific anxieties were included as additional predictors, psychological distress was no longer significant. Cross-lagged panel analyses mostly supported these results. Moreover, disease-specific anxieties mediated the association between psychological distress and end-of-life fears.

Conclusion: Administration and intensity of end-of-life care (especially concerning end-of-life fears) in COPD patients should be based not only on illness severity, but rather on psychological distress and disease-specific anxieties.     

老年肺栓塞临床诊治进展

急性肺栓塞在老年患者中属于高发疾病,并可能严重危及生命,其危险因素、临床表现常因基础疾病的掩盖而造成误诊或漏诊。当患者出现特异性较高的易患因素及晕厥表现,应高度警惕肺栓塞的发生,并根据临床具体条件确定诊查策略,选择合适的诊断手段,尽早确定或排除诊断。抗凝治疗仍是所有肺栓塞患者的基本治疗方法,当血流动力学不稳定时,可以考虑启动溶栓治疗。老年肺栓塞的治疗更强调个体化施治以最大限度地提高治疗收益,降低治疗风险。     

An Open Trial of Telephone-Delivered Mindfulness-Based Cognitive Therapy: Feasibility,Acceptability, and Preliminary Efficacy for Reducing Depressive Symptoms

Mindfulness-based cognitive therapy (MBCT) is a promising intervention for reducing depressive symptoms in individuals with comorbid chronic disease, but the program’s attendance demands make it inaccessible to many who might benefit. We tested the feasibility, acceptability, safety, and preliminary efficacy of an abbreviated, telephone-delivered adaptation of the in-person mindfulness-based cognitive therapy (MBCT-T) program in a sample of patients with depressive symptoms and hypertension.Participants (n = 14; 78.6% female, mean age = 60.6) with mild to moderate depressive symptoms and hypertension participated in the 8-week MBCT-T program. Feasibility was indexed via session attendance and home-based practice completion. Acceptability was indexed via self-reported satisfaction scores. Safety was assessed via reports of symptomatic decline or need for additional mental health treatment. Depressive symptoms (Quick Inventory of Depressive Symptomatology–Self-Report [QIDS-SR]) and anxiety (Hospital Anxiety and Depression Scale—Anxiety subscale; HADS-A) were assessed at baseline and immediately following the intervention.Sixty-four percent of participants (n = 9) attended ≥4 intervention sessions. Seventy-one percent (n = 6) of participants reported completing all assigned formal home practice and 89.2% (n = 8) reported completing all assigned informal practice. Participants were either very satisfied (75%; n = 6) or mostly satisfied (25%; n = 2) with the intervention. There were no adverse events or additional need for mental health treatment. Depressive symptom scores were 4.09 points lower postintervention (p = .004). Anxiety scores were 3.18 points lower postintervention (p = .039).Results support the feasibility, acceptability, safety, and preliminary efficacy of an abbreviated, telephone-delivered version of MBCT for reducing depressive and anxiety symptoms in individuals with co-occurring chronic disease.     

腹内压的变化对肠道氧合及功能的影响

以胃黏膜pH值及血浆D-乳酸为监测指标,观察腹高压患者的腹内压变化前后胃肠道氧合及功能的变化。本研究提示胃黏膜pH值可以反映胃肠道的缺血,且早于腹腔间隙综合征出现,可敏感反映腹高压时肠道氧舍情况;血浆D-乳酸可反映肠缺血再灌注时肠屏障功能状态。以上观察为临床提供简便易行的监测手段及治疗思路。     

关于血管紧张素转换酶抑制药＋β受体阻断药组合的重新审视

采取联合用药方案治疗高血压已成为近年来临床用药的总体趋势。临床用药情况调查结果表明,血管紧张素转换酶抑制药＋β受体阻断药的联合用药组合占有一定的使用率,分析两类药的降压作用以及对高血压常见并发症和对代谢、心率等的影响,可见这个组合是合理的。