Transcranial direct-current stimulation enhances implicit motor sequence learning in persons with Parkinson's disease with mild cognitive impairment

Implicit motor sequence learning (IMSL) is affected in Parkinson's disease (PD). Research in healthy young participants shows the potential for transcranial direct-current stimulation (tDCS) over the primary motor cortex (M1) to enhance IMSL. In PD, only null effects have been reported to date. We determined concurrent, short-term, and long-term effects of anodal tDCS over M1 on IMSL, as measured by the serial reaction time (SRT) task, in persons with PD with mild cognitive impairment (MCI). Concurrent (anodal/sham tDCS intervention during the SRT task), short-term (5 min post-intervention), and long-term (1 week post-intervention) effects on IMSL were evaluated in persons with idiopathic PD (Hoehn and Yahr stage II-III) with MCI. Results of 11 persons with PD (8 men and 3 women; mean age = 77.1 years; mean disease duration = 7.7 years) showed significant IMSL in the anodal (p = .016), but not in the sham tDCS condition (p = .937). Post-hoc analyses showed that IMSL reached statistical significance at 1 week post-intervention (p < .001). Anodal tDCS over M1 exerted beneficial effects on IMSL in persons with PD with MCI, in particular one week post-intervention. Our study is the first to report a positive effect of tDCS on IMSL in PD. Further research should include a larger, more cognitively diverse sample and additional follow-up periods.     

内隐序列学习与中央执行功能的关系

内隐序列学习与一般认知的关系一直处于争议之中。近年来,越来越多的研究显示内隐序列学习与工作记忆（尤其是中央执行功能）存在显著关联。基于此,本研究通过两个实验来探测两者的相关及机制。实验1从行为与脑电两个角度探讨经典位置序列学习与中央执行功能的相关,发现经典位置序列学习的内隐习得量与中央执行功能的抑制、刷新功能的强度呈负相关,与转换功能没有显著相关,脑电结果也支持了这一结论。实验2在内隐序列学习中加入认知冲突来增加中央执行功能的负荷。结果发现在高抑制功能负荷任务条件下,内隐习得量与抑制功能强度的相关性发生了反转,进一步证明内隐序列学习与中央执行功能的抑制子成分在脑功能上的关系：不同条件下呈现竞争、协作等不同状态。     

The relative value of two options for pigeons depends on their context

It is well known that when humans are given a choice between two options, their preference is affected by the presence of a third. Generally, there is an increase in preference for the option closer to the third. We show that a shift in preference in the direction away from the third option can occur in animals. We gave pigeons a choice between A, reinforcement following 10 pecks and a 0.5‐s delay, and B, reinforcement following 5 pecks and a 1.5‐s delay. Once stable preferences were established, we introduced a third stimulus, less preferred than the other two: C, reinforcement following 20 pecks and a 0.5‐s delay or D, reinforcement following 5 pecks and a 4.5‐s delay. We found that pigeons presented with C showed an increased preference for B, whereas pigeons presented with D showed an increased preference for A. Our results were consistent with the similarity or attentional hypothesis, which suggests that the third option should interfere with the option more similar to it or would draw attention to the less preferred component of the third option and generalize to the option more similar to it. Possible accounts for the differences in outcomes are suggested.     

策略转换的成本与顺序效应

灵活的策略转换是个体有效地解决问题的重要条件。策略转换需要成本已得到大量证明,但策略转换成本是否为对称转换成本尚无定论。基于已有研究,对策略转换中存在策略顺序困难效应与较差策略顺序调节效应两种典型的顺序效应进行了具体介绍。在此基础上提出了不对称策略转换成本可能是对称转换成本与策略顺序困难效应之和的假设,并进而提出设想:可通过操纵时间变量来分离策略顺序困难效应与较差策略顺序调节效应。此外,从策略转换成本的角度创新地阐释了策略选择的惰性与倒退现象。     

Limited information estimation and testing of Thurstonian models for paired comparison data under multiple judgment sampling

We relate Thurstonian models for paired comparisons data to Thurstonian models for ranking data, which assign zero probabilities to all intransitive patterns. We also propose an intermediate model for paired comparisons data that assigns nonzero probabilities to all transitive patterns and to some but not all intransitive patterns.There is a close correspondence between the multidimensional normal ogive model employed in educational testing and Thurstone's model for paired comparisons data under multiple judgment sampling with minimal identification restrictions. Alike the normal ogive model, Thurstonian models have two formulations, a factor analytic and an IRT formulation. We use the factor analytic formulation to estimate this model from the first and second order marginals of the contingency table using estimators proposed by Muthén. We also propose a statistic to assess the fit of these models to the first and second order marginals of the contingency table. This is important, as a model may reproduce well the estimated thresholds and tetrachoric correlations, yet fail to reproduce the marginals of the contingency table if the assumption of multivariate normality is incorrect.A simulation study is performed to investigate the performance of three alternative limited information estimators which differ in the procedure used in their final stage: unweighted least squares (ULS), diagonally weighted least squares (DWLS), and full weighted least squares (WLS). Both the ULS and DWLS show a good performance with medium size problems and small samples, with a slight better performance of the ULS estimator.This paper is based on the author's doctoral dissertation; Ulf Böckenholt, advisor. The final stages of this research took place while the author was at the Department of Statistics and Econometrics, Universidad Carlos III de Madrid. The author is indebted to Adolfo Hernández for stimulating discussions that helped improve this paper, and to Ulf Böckenholt and the Associate Editor for a number of helpfulsuggestions to a previous draft.     

先天易的数学基础初探——试论先天卦序与二进位制

本文从自然数及其记数法的基本慨念出发。辨析了与二进位制相关的几个容易混淆的概念,指出序数概念的引入在近代数学发展中有重要意义。作为邵雍数学学派的数学基础,先天易是数学史上第一个专门定义的序数体系,该序数体系在数学史上率先采用了二进位制记数法。先天易作为二进制序数体系这一事实在明清时期引起不同的反响,反对者认为它使易道沦落,大数学家汪莱则从P进制的角度论证它的优越性。本文最后还对近年来反对先天易与二进制有关的两种典型观点进行了剖析．指出其谬误所在。     

Further analysis of antecedent interventions on preschoolers' compliance

Functional analyses were conducted to identify reinforcers for noncompliance exhibited by 3 young children. Next, the effects of three antecedent-based interventions-noncontingent access to a preferred item, a warning, and a high-probability instructional sequence-were examined. The high-probability instructional sequence was effective for 1 child. Antecedent interventions were ineffective and extinction was necessary for the other 2 children.