乙脑患儿血清神经元特异性烯醇化酶、S-100蛋白、髓鞘碱性蛋白测定及其临床意义

为了解流行性乙型脑炎（乙脑）患儿血清神经元特异性烯醇化酶（NSE）、S-100蛋白（S-100）、髓鞘碱性蛋白（MBP）含量变化及其临床意义,用酶联免疫吸附法检测100例乙脑患儿血清NSE、S-100、MBP含量变化。结果显示,乙脑组患儿血清NSE、S-100、MBP含量与对照组比较显著增高（P均〈0．01）,增高程度与病情严重程度相平行（P〈0．01）。因此,血清NSE、S-100、MBP含量测定对乙脑患儿脑损伤严重程度及临床预后判断有重要参考价值。     

内质网应激和胰岛素抵抗

2型糖尿病的发病机制主要涉及胰岛素抵抗,近年来研究表明内质网应激可诱导胰岛素抵抗的形成,并使与改善胰岛素受体敏感性相关的内质网应激标志物分子氧调节蛋白150和转录因子X盒结合蛋白-1表达增强,表明内质网应激对细胞具有双重作用,一方面可诱导胰岛素抵抗,另一方面激发对应激的适应反应。     

原发性骨肉瘤中EGFR和C—erbB-2的表达及其意义

检测20例原发性骨肉瘤和10例骨纤维结构不良中EGFR和C-erbB-2的表达;两者在骨肉瘤中表达的阳性率分别为50%和40%（P＜0.05）,而在骨纤维结构不良中分别为10%和0%（P＜0.05）;骨肉瘤中EGFR和C-erbB-2表达均高于骨纤维结构不良,且呈正相关,这为骨肉瘤的诊疗提供了理论依据。     

MCM蛋白与肿瘤

微小染色体维持蛋白(MCM)是真核生物DNA复制的主要调控因子,在DNA复制的起始和延伸过程中有重要作用,在每个细胞周期中仅发生一次,是标志细胞增殖活性的新指标,对于肿瘤的诊断及预后判断有重要意义。     

Husserl’s appropriation of the psychological concepts of apperception and attention

In the sixth Logical Investigation, Husserl thematizes the surplus (Überschuß) of the perceptual intention whereby the intending goes beyond the partial givenness of a perceptual object to the object as a whole. This surplus is an apperceptive surplus that transcends the purely perceptual substance (Gehalt) or sensed content (empfundene Inhalt) available to a perceiver at any one time. This surplus can be described on the one hand as a synthetic link to future, possible, active experience; to intend an object is to intend it as it would appear if we were to have an exhaustively synthetic explication of it. This perceptual apperceptive surplus is, on the other hand, distinguished from the surplus that categorial form represents over the perceptual sense data. In this paper I show how the apperceptive surplus can also be understood as a synthetic link to past experience that is passively operative in any present perception. The synthetic link to both past and possible experience is a link to non-actual perceptions. Links to non-actual experience are despite their non-actuality nevertheless genuinely intentional in that they enter into the sense of any actively constituted object understood as a unity of sense. Key to this interpretation is an explanation of how Husserl appropriated the key concepts of attention and apperception from psychologists of his day, such as Stumpf and Wundt.     

The Effects of Weight Loss Attempts, Exercise Initiation, and Dietary Practices on Health Related Quality of Life

This study (N = 98) randomly placed participants in either a higher protein or American Heart Association diet group with each group initiating an aerobic exercise program. Body composition (BC) was measured using four different methodologies (DEXA, BIA, skinfold, BMI) along with height and weight, while Health-Related Quality of Life (HRQOL) changes were measured using the Medical Outcomes Short Form 36 (SF-36). There were no significant time/diet interactions in HRQOL scores, body fat measures, and weight with the exception of Role-Physical scores (p = .006) with posttest scores higher in participants in Diet 1. Role-Physical scores changed significantly in participants in Diet 1 (p = .0001) and Diet 2 (p = .026) with higher posttest scores in each group. Social functioning had a significant main effect for time in both groups with pretest scores in both diet groups lower than their respective posttest scores (p = .015). HRQOL pretest scores were not significantly different between groups at baseline (p = .56). ANOVA revealed no significant differences in average calories between groups (p = .88). Analysis revealed no differences in exercise in minutes (p = .66) nor statistically significant changes in BC or weight (p = .65). Conclusions: Improvements in HRQOL were demonstrated in two subscales related to physiological and psychological functioning. These novel findings add to literature suggesting that HRQOL, at least concerning social functioning, work and other daily activities (Role-Physical) may improve by initiating an exercise and dietary program even when weight loss or BC improvements have been unsuccessful.     

The role of vowel formant frequencies and duration in the perception of foreign accent

ABSTRACT

This study used synthesis to manipulate vowel formant frequencies and durations to evaluate their role on foreign accent perception. Formant frequencies and durations for the vowels /æ/, /?/, and /a/ were manipulated with changes toward and away from the mean native English and Spanish-accented values from Sidaras, S. K., Alexander, J. E. D., & Nygaard, L. C. (2009. Perceptual learning of systematic variation in Spanish-accented speech. The Journal of the Acoustical Society of America, 125, 3306–3316). Native listeners rated these stimuli on degree of accentedness and comprehensibility. Gradual changes in formant frequencies from native to non-native values impacted /a/ negatively, /?/ positively, and /æ/ minimally. Effects of vowel duration on either type of ratings were small and restricted to vowel-specific interactions. The current findings suggest that vowel formant frequencies are primary cues to foreign accent. Their influence depends upon whether or not frequencies could reflect alternative vowel categories.     

蛋白质组学与神经科学:从蛋白质到网络

多蛋白质信号复合物在所有细胞中都很重要,它们在脑内信息处理也有着重要作用。质谱、双向凝胶电泳、蛋白亲和技术、高通量的免疫组化方法和蛋白质组信息学都蛋白质组学研究的主要手段。应用蛋白质组学方法可以研究多蛋白信号复合的功能,多样性与组成的动态变化。因此,蛋白质组学发展使得人们从单个蛋白质的研究上升到对蛋白质网络的研究。蛋白质组学研究将为神经与精神疾病的诊断技术与治疗手段提供一条新的道路。     

Before the Two Cultures: Merging the Canons of the History of Science and Philosophy

This article argues that early modern philosophy should be seen as an integrated enterprise of moral and natural philosophy. Consequently, early modern moral and natural philosophy should be taught as intellectual enterprises that developed hand in hand. Further, the article argues that the unity of these two fields can be best introduced through methodological ideas. It illustrates these theses through a case study on Scottish Newtonianism, starting with visions concerning the unity of philosophy and then turning to a discussion of how methodological ideas figure in those visions. Finally, the article argues that methodological considerations can serve as good starting points to introduce and discuss central topics and canonical figures of the early modern period.     

Influence of Zn incorporation on the microstructural and magnetic properties of La0.67Sr0.33Mn1−xZnxO3 nanoparticles synthesised by the sol–gel method

Perovskite manganite nanoparticles with the chemical formula La_0.67Sr_0.33Mn_1?xZn_xO₃ (x = 0, 0.1 and 0.2) were prepared by the sol–gel process and the influence of Zn substitution on their microstructural and magnetic properties studied in detail. X-ray diffractometry (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were employed for crystal structure determination and microstructural analysis. The results of XRD analysis confirmed the polycrystalline nature and rhombohedral crystal structure with space group R(-3c) for all compositions. SEM micrographs of the samples revealed an agglomeration/well-connected appearance of the particles. The composition and uniform distribution of all the elements were established by energy-dispersive spectroscopy. TEM images clearly confirmed an almost spherical shape of the nanoparticles with an average particle size of about 11, 14 and 13 nm for the 0, 10 and 20% Zn-doped samples, respectively. The magnetic behaviour of the nanoparticles was studied at room temperature with a vibrating sample magnetometer (VSM) up to a field of 1.8 Tesla. These measurements established a superparamagnetic nature with a variation in the saturation magnetization (M_s) with Zn content.