肝脏X受体研究在心血管疾病中的应用展望

肝脏X受体(Liver X Receptor,LXR)是新近研究比较深入的一个热点话题,LXR主要参与胆固醇代谢和转运、脂肪代谢、糖原异生和炎症等过程。本文在LXR的结构、功能、其激动剂及其可能的临床作用、未来的研究方向等多个方面进行了详细的阐述。     

Chinese Philosophy of Value over the Past Four Decades

Chinese philosophy of value arose from reflection on the Cultural Revolution and an inherent need amidst the implementation of reform and opening up, and it was directly triggered by extensive discussions about the standard of truth. The development of the philosophy of value over the past forty years shifted from value to evaluation before moving on to the research topics of values, in particular core socialist values. Currently, its major characteristics are the unity of theoretical logic and practical logic, the mutual interaction between and enhancement of the study of the philosophy of value and research on Marxist philosophy, and exchanges and dialogues with foreign philosophies of value. Its main achievements in the philosophy of value include the implementation of a subjective paradigm based on the theory of practice and the theoretical construction and clarification of core socialist values. Future directions for the development of the philosophy of value include improving subjective interpretation on the basis of the theory of practice, deeply exploring value concepts and value principles in the new form of civilization, and bringing the philosophy of value into interaction with multidisciplinary research.     

A FORMAL CONSTRUCTION OF THE SPACETIME MANIFOLD

The spacetime manifold, the stage on which physics is played, is constructed ab initio in a formal program that resembles the logicist reconstruction of mathematics. Zermelo’s set theory extended by urelemente serves as a framework, to which physically interpretable proper axioms are added. From this basis, a topology and subsequently a Hausdorff manifold are readily constructed which bear the properties of the known spacetime manifold. The present approach takes worldlines rather than spacetime points to be primitive, having them represented by urelemente. Thereby it is demonstrated that an important part of physics is formally reducible to set theory.     

Loss aversion,diminishing sensitivity,and the effect of experience on repeated decisions

Three experiments are presented that explore the assertion that loss aversion and diminishing sensitivity drive the effect of experience on choice behavior. The experiments are focused on repeated choice tasks where decision makers choose repeatedly between alternatives and get feedback after each choice. Experiments 1a and 1b show that behavioral tendencies that were previously interpreted as indications of loss aversion in decisions from experience are better described as products of diminishing sensitivity to absolute payoffs. Experiment 2 highlights a nominal magnitude effect: A decrease in the magnitude of the nominal payoffs eliminates the evidence for diminishing sensitivity. These and related previous results can be captured with a model that assumes reliance on small samples of subjective experiences, and an increase in diminishing sensitivity with payoff variability. Copyright © 2008 John Wiley & Sons, Ltd.     

框架效应及其认知机制的研究进展

框架效应违背了不变性原则,是描述性决策理论违背规范性理论的经典异像。以亚洲疾病问题为代表的经典框架效应又称作风险选择框架效应,此外还包括特征框架效应等不同类别。框架效应受损益值类型和大小等社会线索影响。除展望理论可以解释其认知机制外,模糊痕迹理论和概率心理模型等也对此加以解释。框架效应的脑机制在大脑右半球和杏仁核等区域。文章最后对全文做了总结及展望。     

Financial prospect relativity: context effects in financial decision‐making under risk

We report three studies in which methodologies from psychophysics are adapted to investigate context effects on individual financial decision‐making under risk. The aim was to determine how the range and the rank of the options offered as saving amounts and levels of investment risk influence people's decisions about these variables. In the range manipulation, participants were presented with either a full range of choice options or a limited subset, while in the rank manipulation they were presented with a skewed set of feasible options. The results showed that choices are affected by the position of each option in the range and the rank of presented options, which suggests that judgments and choices are relative. Copyright © 2006 John Wiley & Sons, Ltd.     

Re-evaluating evidence for linguistic relativity: reply to Boroditsky (2001)

Six unsuccessful attempts at replicating a key finding in the linguistic relativity literature [Boroditsky, L. (2001). Does language shape thought?: Mandarin and English speakers' conceptions of time. Cognitive Psychology, 43, 1-22] are reported. In addition to these empirical issues in replicating the original finding, theoretical issues present in the original report are discussed. In sum, we conclude that Boroditsky (2001) provides no support for the Whorfian hypothesis.     

Scaling relative incentive value in anticipatory behavior

Papini and Pellegrini (Papini, M. R., & Pellegrini, S. Scaling relative incentive value in consummatory behavior. Learning and Motivation, in press) observed that, within limits, the level of consummatory responding of rats exposed to incentive downshifts in the concentration of sucrose solutions was similar when the ratio of test/training solutions was the same. For example, 32 → 4% and 16 → 2% downshifts (1:8 test/training ratios) lead to similar levels of consummatory behavior, despite differences in the absolute concentrations of the solutions involved in the downshift. This suggests the applicability of Weber’s law to spaced-trial, incentive-downshift situations. Experiment 1 extended these results to runway performance using food pellets as reward, and Experiment 2 to lever pressing performance, using an autoshaping procedure and sucrose solutions as rewards. The results conform well to the test/training ratio suggesting that Weber’s law is applicable to anticipatory behavior. A simple mathematical rule that can be easily incorporated into models based on linear operators describes the results of consummatory and anticipatory behavior experiments.     

Thresholds for color discrimination in English and Korean speakers

Categorical perception (CP) is said to occur when a continuum of equally spaced physical changes is perceived as unequally spaced as a function of category membership (Harnad, S. (Ed.) (1987). Psychophysical and cognitive aspects of categorical perception: A critical overview. Cambridge: Cambridge University Press). A common suggestion is that CP for color arises because perception is qualitatively distorted when we learn to categorize a dimension. Contrary to this view, we here report that English speakers show no evidence of lowered discrimination thresholds at the boundaries between blue and green categories even though CP is found at these boundaries in a supra-threshold task. Furthermore, there is no evidence of different discrimination thresholds between individuals from two language groups (English and Korean) who use different color terminology in the blue-green region and have different supra-threshold boundaries. Our participants’ just noticeable difference (JND) thresholds suggest that they retain a smooth continuum of perceptual space that is not warped by stretching at category boundaries or by within-category compression. At least for the domain of color, categorical perception appears to be a categorical, but not a perceptual phenomenon.     

证券交易中处置效应的实验研究

该项研究通过控制五只股票、每只股票有18期价格波动的实验来研究中国投资者的投资行为特征。结果发现,被试并没有表现出Bayesian最优行为,处置效应却很明显;被试之间在性别、专业、受教育程度与入市时间上的差异不构成处置效应程度上的差异。但入市资金量在5％的水平上对处置效应程度有显著作用。尽管实验中还发现均值反转信念发生作用的证据,但相对于处置效应而言,解释力度要弱。