Differential Diagnosis of the Major Progressive Dementias and Depression in Middle and Late Adulthood: A Summary of the Literature of the Early 1990s

There is a preponderance of research on the neuropsychology of the various dementias. There are also direct comparisons between two or more dementias available in the literature. This paper sought to summarize the most recent literature, primarily from 1990 through mid-1996, including recent reviews of the literature from previous decades. The purpose was to provide, in one location, a summary of neuropsychological (i.e., cognitive, motor, and psychiatric) characteristics of major noninfectious, progressive dementias and depression of middle and late adulthood. It is hoped that this review, particularly a summary table provided, will serve as a guide in the differential diagnosis of the dementias by clinicians. In addition to Alzheimer's disease, vascular dementias, Parkinson's disease, Lewy body dementia, Huntington's disease, and frontal lobe dementia, the impact of depression on cognitive functioning is covered given the frequency with which neuropsychologists are asked to differentiate depression from primary dementia.     

Response persistence under ratio and interval reinforcement schedules

In Experiment 1, rats were exposed to progressive-ratio schedules of food reinforcement while other rats were exposed simultaneously to yoked-interval schedules that arranged equivalent interreinforcer intervals but required only a single response at the end of the interval for food delivery. In Experiment 2, a within-subject yoked-control procedure was employed in which pigeons were exposed to alternating sessions (one per day) of progressive-ratio schedules and yoked-interval schedules as described above. In both experiments, responding under the yoked-interval schedule persisted beyond the point at which responding under the progressive-ratio schedule had ceased. The progressive-ratio schedules controlled break-and-run distributions, and the yoked-interval schedules controlled more even distributions of responses in time. Response rates decreased and postreinforcement pauses increased over time within individual sessions under both schedules. The results suggest that responding maintained by interval schedules is more persistent than that maintained by ratio schedules. The limitations and implications of this conclusion are discussed in the context of other investigations of response strength and behavioral momentum.     

Standard and Short RoM Isokinetic Testing: Comparative Analysis in Identifying Submaximal Shoulder External Rotator Effort

An isokinetic-related parameter termed the difference between eccentric-concentric strength ratios at two distinct test velocities (DEC) based on 60° (standard) range of motion (RoM) has been proven to be highly efficient detecting feigned muscular efforts. This study aimed to verify whether a DEC derived from a much shorter test RoM (20°) was equally useful than a long RoM–derived one. Eighteen healthy men (32.4 ± 6.4 years old) took part in a study focusing on shoulder external rotation isokinetic strength. Participants performed a genuine shoulder external rotator maximal effort (eight pairs of concentric and eccentric contractions at high and low velocities at short and long RoM) and then instructed to feign maximal effort. Contraction velocities were adjusted accordingly by applying a 1:4 gradient and peak moments registered. Both condition DEC was then calculated by subtracting the eccentric and concentric strength ratios at low velocities from those at high velocities. DEC scores in the feigned effort were significantly higher than maximal effort ones in both conditions in men. It enabled the setting of specific cutoff levels for separating the efforts. Both approaches revealed a coincident sensitivity (78%) whereas short RoM showed an even higher specificity: 88% versus 78%. Thus, the short RoM protocol provides clinically acceptable detection power.     

Unilateral Fatigue Affects the Unipedal Postural Balance in Individuals With Intellectual Disability

This study aimed to explore the effect of local muscle fatigue on the unipedal stance in men with intellectual disability (ID). The Centre of pressure (CoP) excursions and the isometric maximal voluntary contraction (MVC) were measured before and after a fatiguing exercise. Higher baseline values of CoP excursions and lower MVC values were recorded in the ID group. After the fatiguing exercise, this group showed higher MVC decrease and higher percentage of increase of the mean CoP velocity. In conclusion, men with ID are more vulnerable to the disturbing effects of fatigue during the unipedal stance compared to men without ID.     

Muscular Activation Pattern of Bilateral Extensors Response to Asymmetric Hand Lifting During Trunk Flexion–extension Performance

The authors' purpose was to test the effect of asymmetric hand lifting on muscular activation patterns of 3 bilateral extensors. Eighteen male university students without back pain were volunteered. Each performed flexion–extension randomly with conditions of right lifting, left lifting, and nonlifting. Surface electromyography from bilateral thoracic, lumbar erector spinae, and hamstring was recorded. The cross-correlation and relative intensity in paired muscles of bilateral extensors was calculated in flexion as well as extension period. The results showed that the cross-correlation coefficient was decreased and the phase lag as well as the relative intensity of bilateral extensors was increased significantly in thoracic level. The phase lag as well as the relative intensity of bilateral extensors was increased significantly in lumbar level. It was concluded that asymmetric lifting has a significant effect on muscular activation of bilateral extensors in thorax level, which causes the ipsilateral extensor to activate larger and longer. Asymmetric lifting also has some effect on muscular activation of bilateral extensors in lumbar level but with less extent than in thorax level, which causes contralateral extensor to activate larger and longer. Asymmetric lifting seems to have no significant effect on muscular activation of bilateral hamstring.     

汉语母语者英语动词三种屈折变化形式加工机制的差异

采用ERP技术考察了汉语母语者,英语动词三种屈折变化形式加工机制的差异。结果发现,英语动词进行式的屈折变化形式- ing的错误使用诱发了P600成分;完成式的屈折变化形式- ed的错误使用诱发了N400成分;完成式中没有明显屈折变化标识的不规则词的错误使用没有诱发典型的ERP成分。研究结果表明：对于缺乏英语使用环境、母语为汉语的晚期英语学习者来说,屈折变化形式- ing,完成式规则动词的变化形式- ed和没有明显形态变化标识的不规则动词的变化形式具有不同的加工机制,前者可能处于由陈述性记忆系统向程序性记忆系统加工的转变过程中,而后两者更多地由陈述性系统进行加工。这种加工机制的差异可能与动词屈折变化规则的复杂程度有关。     

进展性脑卒中诊治及相关因素分析

进展性脑卒中是缺血性脑血管病最常见的一个临床现象,进展性脑卒中的存在严重影响卒中患者的预后。迄今为止,关于其流行病学资料、发病机制、诊断标准、治疗均是极具挑战性的问题。进展性脑卒中可能是多种原因、多种病理机制所产生的多种状态的组合,治疗的手段应该以开放动脉或通过全身治疗的方法来增加脑灌注压为主。     

EFFECT OF REINFORCER MAGNITUDE ON PERFORMANCE MAINTAINED BY PROGRESSIVE‐RATIO SCHEDULES

This experiment examined the relationship between reinforcer magnitude and quantitative measures of performance on progressive‐ratio schedules. Fifteen rats were trained under a progressive‐ratio schedule in seven phases of the experiment in which the volume of a 0.6‐M sucrose solution reinforcer was varied within the range 6–300 μl. Overall response rates in successive ratios conformed to a bitonic equation derived from Killeen's (1994) Mathematical Principles of Reinforcement. The “specific activation” parameter, a, which is presumed to reflect the incentive value of the reinforcer, was a monotonically increasing function of reinforcer volume; the “response time” parameter, δ, which defines the minimum response time, increased as a function of reinforcer volume; the “currency” parameter, b, which is presumed to reflect the coupling of responses to the reinforcer, declined as a function of volume. Running response rate (response rate calculated after exclusion of the postreinforcement pause) decayed monotonically as a function of ratio size; the index of curvature of this function increased as a function of reinforcer volume. Postreinforcement pause increased as a function of ratio size. Estimates of a derived from overall response rates and postreinforcement pauses showed a modest positive correlation across conditions and between animals. Implications of the results for the quantification of reinforcer value and for the use of progressive‐ratio schedules in behavioral neuroscience are discussed.     

AGGRESSION AS POSITIVE REINFORCEMENT IN MICE UNDER VARIOUS RATIO‐ AND TIME‐BASED REINFORCEMENT SCHEDULES

There is evidence suggesting aggression may be a positive reinforcer in many species. However, only a few studies have examined the characteristics of aggression as a positive reinforcer in mice. Four types of reinforcement schedules were examined in the current experiment using male Swiss CFW albino mice in a resident—intruder model of aggression as a positive reinforcer. A nose poke response on an operant conditioning panel was reinforced under fixed‐ratio (FR 8), fixed‐interval (FI 5‐min), progressive ratio (PR 2), or differential reinforcement of low rate behavior reinforcement schedules (DRL 40‐s and DRL 80‐s). In the FR conditions, nose pokes were maintained by aggression and extinguished when the aggression contingency was removed. There were long postreinforcement pauses followed by bursts of responses with short interresponse times (IRTs). In the FI conditions, nose pokes were maintained by aggression, occurred more frequently as the interval elapsed, and extinguished when the contingency was removed. In the PR conditions, nose pokes were maintained by aggression, postreinforcement pauses increased as the ratio requirement increased, and responding was extinguished when the aggression contingency was removed. In the DRL conditions, the nose poke rate decreased, while the proportional distributions of IRTs and postreinforcement pauses shifted toward longer durations as the DRL interval increased. However, most responses occurred before the minimum IRT interval elapsed, suggesting weak temporal control of behavior. Overall, the findings suggest aggression can be a positive reinforcer for nose poke responses in mice on ratio‐ and time‐based reinforcement schedules.     

Assessing reinforcers under progressive schedule requirements.

Recent research findings suggest that reinforcing stimuli may be differentially effective as response requirements increase. We extended this line of research by evaluating responding under increasing schedule requirements via progressive‐ratio schedules and behavioral economic analyses. The differential effectiveness of preferred stimuli in treating destructive behavior maintained by automatic reinforcement also was examined. Results showed that one of two stimuli was associated with more responding under increasing schedule requirements for the 4 participants. Furthermore, stimuli associated with more responding under increasing schedule requirements generally were more effective in treating destructive behavior than stimuli associated with less responding. These data suggest that progressive‐ratio schedules and behavioral economic analyses may be useful for developing a new technology for reinforcer identification. From a clinical perspective, these results suggest that two reinforcers may be similarly effective for low‐effort tasks and differentially effective for high‐effort tasks.