Prime and probability: causal knowledge affects inferential and predictive effects on self-agency experiences

Experiences of having caused a certain outcome may arise from motor predictions based on action–outcome probabilities and causal inferences based on pre-activated outcome representations. However, when and how both indicators combine to affect such self-agency experiences is still unclear. Based on previous research on prediction and inference effects on self-agency, we propose that their (combined) contribution crucially depends on whether people have knowledge about the causal relation between actions and outcomes that is relevant to subsequent self-agency experiences. Therefore, we manipulated causal knowledge that was either relevant or irrelevant by varying the probability of co-occurrence (50% or 80%) of specific actions and outcomes. Afterwards, we measured self-agency experiences in an action–outcome task where outcomes were primed or not. Results showed that motor prediction only affected self-agency when relevant actions and outcomes were learned to be causally related. Interestingly, however, inference effects also occurred when no relevant causal knowledge was acquired.     

Plasticity associated with escalated operant ethanol self-administration during acute withdrawal in ethanol-dependent rats requires intact matrix metalloproteinase systems

Repeated cycles of ethanol intoxication and withdrawal associated with dependence induce neuroadaptations in a variety of brain systems. Withdrawal-induced negative emotional states can be ameliorated by ethanol consumption; a learned process termed negative reinforcement. Accordingly, a dependence-induced phenotype is escalated ethanol self-administration. Matrix metalloproteinases (MMPs) are proteolytic enzymes which degrade the extracellular matrix to allow for synaptic reorganization and plasticity. To test the hypothesis that an intact MMP system is required for animals to learn about the negative reinforcing effects of ethanol and display escalated self-administration during acute withdrawal when ethanol-dependent, male Wistar rats were trained to self-administer ethanol and then assigned to either acute or chronic MMP inhibition treatment groups. The chronic treatment group received intracerebroventricular (ICV) infusions of the broad spectrum MMP inhibitor FN-439 or artificial cerebrospinal fluid (aCSF) via osmotic minipumps during a 1 month ethanol dependence induction period and subsequent post-dependence induction self-administration sessions that occurred during acute withdrawal. The acute treatment group only received ICV FN-439 or aCSF on the day of self-administration sessions following dependence induction during acute withdrawal. The results showed that inhibition of MMPs attenuated escalated ethanol self-administration following chronic and acute exposure conditions. Furthermore, once learning (i.e., plasticity) had occurred, MMP inhibition had no impact on escalated response patterns and animals previously subjected to MMP inhibition that did not escalate evidenced normal escalations in operant ethanol self-administration once FN-439 treatments were terminated. Thus, the present data identified that an intact MMP system is required for the escalated responding that occurs during acute withdrawal in dependent animals and implicate such escalation as a learned response.     

Intracellular calcium chelation and pharmacological SERCA inhibition of Ca2+ pump in the insular cortex differentially affect taste aversive memory formation and retrieval

Variation in intracellular calcium concentration regulates the induction of long-term synaptic plasticity and is associated with a variety of memory/retrieval and learning paradigms. Accordingly, impaired calcium mobilization from internal deposits affects synaptic plasticity and cognition in the aged brain. During taste memory formation several proteins are modulated directly or indirectly by calcium, and recent evidence suggests the importance of calcium buffering and the role of intracellular calcium deposits during cognitive processes. Thus, the main goal of this research was to study the consequence of hampering changes in cytoplasmic calcium and inhibiting SERCA activity by BAPTA-AM and thapsigargin treatments, respectively, in the insular cortex during different stages of taste memory formation. Using conditioned taste aversion (CTA), we found differential effects of BAPTA-AM and thapsigargin infusions before and after gustatory stimulation, as well as during taste aversive memory consolidation; BAPTA-AM, but not thapsigargin, attenuates acquisition and/or consolidation of CTA, but neither compound affects taste aversive memory retrieval. These results point to the importance of intracellular calcium dynamics in the insular cortex during different stages of taste aversive memory formation.     

Extinction of appetitive learning is disrupted by cycloheximide and propranolol in the sand maze in rats

The present study investigated whether memory for extinction in an appetitive task (the sand maze) could be attenuated by administration of cycloheximide (protein synthesis inhibitor) or propranolol (β-adrenergic receptor antagonist). Ninety-day-old male Long-Evans rats were trained to retrieve a sweet cereal reinforcer from an open container in the sand maze. One day following this non-spatial training, rats received three extinction trials in which they were placed in the maze with the reinforcer present, but unattainable. Thirty minutes prior to the first extinction trial, rats received an intraperitoneal injection of cycloheximide (1mg/kg), propranolol (25mg/kg), or vehicle (1mg/kg distilled water). Twenty-four hours later, rats were tested in the sand maze with the reinforcer again available. Results from the test trial showed that both cycloheximide and propranolol groups found the reinforcer more quickly than controls. Two weeks later, rats were trained on a spatial version of the sand maze in which they had to search for a buried reinforcer using extramaze cues. Cycloheximide and propranolol groups learned this task significantly faster than the control group, demonstrating the long-lasting effect of cycloheximide and propranolol on the blocking of memory for extinction.     

The phonological store abandoned

Baddeley and Larsen (2007) argue that a number of key findings reported by Jones, Macken, and Nicholls (2004) and Jones, Hughes, and Macken (2006) pointing to shortcomings of the phonological store construct arise from the store being abandoned with long lists. In our rejoinder we point out that Baddeley and Larsen use a procedure in which retrieval from the supposed phonological storage would not—according to their own theory—have been possible, and we present theoretical, empirical, and logical problems with their “store abandonment” argument and highlight a number of difficulties associated with the interpretation of suffix and prefix effects. We conclude that our data are still problematic for the phonological store construct and suggest that a reformulation of short-term memory theory needs to embody (or indeed focus exclusively upon) perceptual and effector systems rather than bespoke storage modules.     

Attention and expectation in human predictive learning: The role of uncertainty

Three localized, visual pattern stimuli were trained as predictive signals of auditory outcomes. One signal partially predicted an aversive noise in Experiment 1 and a neutral tone in Experiment 2, whereas the other signals consistently predicted either the occurrence or absence of the noise. The expectation of the noise was measured during each signal presentation, and only participants for whom this expectation demonstrated contingency knowledge showed differential attention to the signals. Importantly, when attention was measured by visual fixations, the contingency-aware group attended more to the partially predictive signal than to the consistent predictors in both experiments. This profile of visual attention supports the Pearce and Hall (1980) Pearce, J. M. and Hall, G. 1980. A model for Pavlovian learning: Variations in the effectiveness of conditioned but not unconditioned stimuli. Psychological Review, 87: 532–552. [Crossref], [PubMed], [Web of Science ®] , [Google Scholar] theory of the role of attention in associative learning.     

Applying an exemplar model to the artificial-grammar task: Inferring grammaticality from similarity

We present three artificial-grammar experiments. The first used position constraints, and the second used sequential constraints. The third varied both the amount of training and the degree of sequential constraint. Increasing both the amount of training and the redundancy of the grammar benefited participants' ability to infer grammatical status; nevertheless, they were unable to describe the grammar. We applied a multitrace model of memory to the task. The model used a global measure of similarity to assess the grammatical status of the probe and captured performance both in our experiments and in three classic studies from the literature. The model shows that retrieval is sensitive to structure in memory, even when individual exemplars are encoded sparsely. The work ties an understanding of performance in the artificial-grammar task to the principles used to understand performance in episodic-memory tasks.     

Transfer of orthogonal stimulus–response mappings to an orthogonal Simon task

When up–down stimulus locations are mapped to left–right keypresses, an overall advantage for the up–right/down–left mapping is often obtained that varies as a function of response eccentricity. This orthogonal stimulus–response compatibility (SRC) effect also occurs when stimulus location is irrelevant, a phenomenon called the orthogonal Simon effect, and has been attributed to correspondence of stimulus and response code polarities. The Simon effect for horizontal stimulus–response (S–R) arrangements has been shown to be affected by short-term S–R associations established through the mapping used for a prior SRC task in which stimulus location was relevant. We examined whether such associations also transfer between orthogonal SRC and Simon tasks and whether correspondence of code polarities continues to contribute to performance in the Simon task. In Experiment 1, the orthogonal Simon effect was larger after practising with an up–right/down–left mapping of visual stimuli to responses than with the alternative mapping, for which the orthogonal Simon effect tended to reverse. Experiment 2 showed similar results when practice was with high (up) and low (down) pitch tones, though the influence of practice mapping was not as large as that in Experiment 1, implying that the short-term S–R associations acquired in practice are at least in part not modality specific. In Experiment 3, response eccentricity and practice mapping were shown to have separate influences on the orthogonal Simon effect, as expected if both code polarity and acquired S–R associations contribute to performance.     

Movements or targets: What makes an action in action–effect learning?

According to ideomotor theory, actions become linked to the sensory feedback they contingently produce, so that anticipating the feedback automatically evokes the action it typically results from. Numerous recent studies have provided evidence in favour of such action–effect learning but left an important issue unresolved. It remains unspecified to what extent action–effect learning is based on associating effect-representations to representations of the performed movements or to representations of the targets at which the behaviour aimed at. Two experiments were designed to clarify this issue. In an acquisition phase, participants learned the contingency between key presses and effect tones. In a following test phase, key–effect and movement–effect relations were orthogonally assessed by changing the hand–key mapping for one half of the participants. Experiment 1 showed precedence for target–effect over movement–effect learning in a forced-choice RT task. In Experiment 2, target–effect learning was also shown to influence the outcome of response selection in a free-choice task. Altogether, the data indicate that both movement–effect and target–effect associations contribute to the formation of action–effect linkages—provided that movements and targets are likewise contingently related to the effects.     

Action sequences within and across hands: Evidence for hand-related sequence learning

Recent research into the acquisition of action sequences involving both hands suggests that the hand-related (sub)sequences are learned at least partly independently of one another. Here we investigated hand-related sequence learning with a novel approach. Eight stimuli were divided into two sets. Participants responded simultaneously to a pair of stimuli (one from each set) with keystrokes of both hands. The stimuli from one set appeared according to a probabilistic structure; no such structure was imposed on the other set of stimuli. The structured stimuli either were assigned to keystrokes of one hand only or were evenly distributed across keystrokes of both hands. Sequence learning was more pronounced under the within-hands assignment than under the across-hands assignment. This finding corroborates hand-related sequence learning and suggests that the executing hand constitutes a dimension that facilitates learning of sequential regularities among elements that pertain to this hand.