The role of Broca's area in speech perception: evidence from aphasia revisited

Motor theories of speech perception have been re-vitalized as a consequence of the discovery of mirror neurons. Some authors have even promoted a strong version of the motor theory, arguing that the motor speech system is critical for perception. Part of the evidence that is cited in favor of this claim is the observation from the early 1980s that individuals with Broca’s aphasia, and therefore inferred damage to Broca’s area, can have deficits in speech sound discrimination. Here we re-examine this issue in 24 patients with radiologically confirmed lesions to Broca’s area and various degrees of associated non-fluent speech production. Patients performed two same-different discrimination tasks involving pairs of CV syllables, one in which both CVs were presented auditorily, and the other in which one syllable was auditorily presented and the other visually presented as an orthographic form; word comprehension was also assessed using word-to-picture matching tasks in both auditory and visual forms. Discrimination performance on the all-auditory task was four standard deviations above chance, as measured using d′, and was unrelated to the degree of non-fluency in the patients’ speech production. Performance on the auditory–visual task, however, was worse than, and not correlated with, the all-auditory task. The auditory–visual task was related to the degree of speech non-fluency. Word comprehension was at ceiling for the auditory version (97% accuracy) and near ceiling for the orthographic version (90% accuracy). We conclude that the motor speech system is not necessary for speech perception as measured both by discrimination and comprehension paradigms, but may play a role in orthographic decoding or in auditory–visual matching of phonological forms.     

A brief review on the use of functional near-infrared spectroscopy (fNIRS) for language imaging studies in human newborns and adults

Upon stimulation, real time maps of cortical hemodynamic responses can be obtained by non-invasive functional near-infrared spectroscopy (fNIRS) which measures changes in oxygenated and deoxygenated hemoglobin after positioning multiple sources and detectors over the human scalp. The current commercially available transportable fNIRS systems have a time resolution of 1-10 Hz, a depth sensitivity of about 1.5 cm, and a spatial resolution of about 1 cm. The goal of this brief review is to report infants, children and adults fNIRS language studies. Since 1998, 60 studies have been published on cortical activation in the brain’s classic language areas in children/adults as well as newborns using fNIRS instrumentations of different complexity. In addition, the basic principles of fNIRS including features, strengths, advantages, and limitations are summarized in terms that can be understood even by non specialists. Future prospects of fNIRS in the field of language processing imaging are highlighted.     

Neural dissociation of phonological and visual attention span disorders in developmental dyslexia: FMRI evidence from two case reports

A dissociation between phonological and visual attention (VA) span disorders has been reported in dyslexic children. This study investigates whether this cognitively-based dissociation has a neurobiological counterpart through the investigation of two cases of developmental dyslexia. LL showed a phonological disorder but preserved VA span whereas FG exhibited the reverse pattern. During a phonological rhyme judgement task, LL showed decreased activation of the left inferior frontal gyrus whereas this region was activated at the level of the controls in FG. Conversely, during a visual categorization task, FG demonstrated decreased activation of the parietal lobules whereas these regions were activated in LL as in the controls. These contrasted patterns of brain activation thus mirror the cognitive disorders’ dissociation. These findings provide the first evidence for an association between distinct brain mechanisms and distinct cognitive deficits in developmental dyslexia, emphasizing the importance of taking into account the heterogeneity of the reading disorder.     

Neural correlates of feigned memory impairment are distinguishable from answering randomly and answering incorrectly: an fMRI and behavioral study

Previous functional magnetic resonance imaging (fMRI) studies have identified activation in the prefrontal-parietal-sub-cortical circuit during feigned memory impairment when comparing with truthful telling. Here, we used fMRI to determine whether neural activity can differentiate between answering correctly, answering randomly, answering incorrectly, and feigned memory impairment. In this study, 12 healthy subjects underwent block-design fMRI while they performed digit task of forced-choice format under four conditions: answering correctly, answering randomly, answering incorrectly, and simulated feigned memory impairment. There were three main results. First, six areas, including the left prefrontal cortex, the left superior temporal lobe, the right postcentral gyrus, the right superior parietal cortex, the right superior occipital cortex, and the right putamen, were significantly modulated by condition type. Second, for some areas, including the right superior parietal cortex, the right postcentral gyrus, the right superior occipital cortex, and the right putamen, brain activity was significantly greater in feigned memory impairment than answering randomly. Third, for the areas including the left prefrontal cortex and the right putamen, brain activity was significantly greater in feigned memory impairment than answering incorrectly. In contrast, for the left superior temporal lobe, brain activity was significantly greater in answering incorrectly than feigned memory impairment. The results suggest that neural correlates of feigned memory impairment are distinguishable from answering randomly and answering incorrectly in healthy subjects.     

比较改革前后的中国医疗卫生体制与伦理的优先

中国的医疗卫生问题近几年来一直是一个重大的社会热点问题。过去的市场化的医疗卫生有许多缺陷,特别是有重大的伦理缺陷。通过比较分析中国改革前后的医疗卫生特点,提出了今后中国医疗卫生体制改革以及伦理优先的思想轮廓。     

西北农村地区母亲抑郁与幼儿社交退缩:母亲回应性的中介作用

以甘肃省陇南市成县6所幼儿园301名农村幼儿及其母亲为研究对象,采用流调中心抑郁量表（CES-D）、母亲教养方式量表和Achenbach儿童行为量表（CBCL）分别考察母亲抑郁、母亲回应性和幼儿社交退缩的现状及相互关系。主要结果如下：（1）西北农村地区母亲抑郁发生率较高,父亲外出打工和贫困家庭的母亲抑郁发生率更高;（2）母亲抑郁与幼儿社交退缩行为显著正相关,母亲抑郁水平越高,幼儿社交退缩得分越高;（3）母亲敏感性和反应性与幼儿社交退缩显著负相关,母亲敏感性和反应性得分越高,幼儿社交退缩得分越低;（4）母亲反应性在母亲抑郁和幼儿社交退缩之间起部分中介作用。     

选择性颞叶梗塞对鼠学习记忆能力影响的定量研究

应用光化学的方法选择性诱导颞叶梗塞,同时测定学习记忆能力、神经功能缺失及梗塞面积。结果表明：颞叶梗塞鼠的学习记忆能力显著受损,但无明显感觉运动障碍;颞叶梗塞鼠的学习记忆受损程度与梗塞面积大小有关。结果提示选择性颞叶梗塞是一种理想的痴呆动物模型。     

Macrosocial determinants of social integration: Social class and area effect

Theory and research on social support have paid little attention to the existence of important macrosocial variables determining level and content of social relationships. This study examines variations in social integration as a function of social class and residential area characteristics. Results for 234 subjects living in high and low risk neighbourhoods indicated that differences between higher and lower social class groups follow different patterns in different residential areas. Also, same social class position appeared to have different significance as a function of residential area characteristics. The levels of three social integration measures—community integration and satisfaction, community association and participation, and contribution in community organizations—were significantly higher for lower class in low risk neighbourhoods than in high risk ones. However, significant differences were found in only one measure for higher social class groups, with higher levels of community association and participation in high risk neighbourhoods than in low risk ones. The discussion examines a ‘social impoverishment’ hypothesis for high risk environments, and proposes possible protective factors for higher status residents. Relations between formal and informal sources of support, and implications for social intervention strategies are also considered.     

东莨菪碱所致记忆障碍的脑内突触机制

研究问题是东莨菪碱所致记忆障碍的脑内突触机制,在东莨菪碱所致记忆障碍模型上定量分析屯小鼠海马ＣＡ３区ＧｒａｙＩ突触界面结构参数的变化。