外周型原始神经外胚层肿瘤1例

原始神经外胚叶肿瘤是一种罕见的、起源于原始神经上皮的恶性小圆形细胞肿瘤,具有多方向分化能力,可发展为神经元性的、胶质细胞性的、甚至间叶组织性质的肿瘤.根据发病部位将其分为中枢型和外周型两种,中枢型多发于脑和脊髓,外周型多见于胸壁、四肢,发生于脊柱者少见.本文就外周型原始神经外胚层肿瘤1例做病例报道,总结该类肿瘤的特点,肿瘤密度/信号不均匀,轻至中度强化,预后差,临床治疗手段主要为外科手术辅以放化疗,术前行增强CT对手术可切除性评估非常有价值.     

PHILOSOPHICAL QUESTIONS AND BIOLOGICAL FINDINGS,PART I: HUMAN COOPERATIVITY,COMPETITION, AND AGGRESSION

This Part II of a two-part article illustrates how research in evolutionary biology, anthropology, archeology, and psychology illuminates questions arising in philosophy—specifically questions about René Girard's theory of aggression. Part I looked at: (i) how old the systemic practice of severe aggression is; (ii) how much of it results from humanity's mimetic/social and competitive nature and how much from ecological, resource, and cultural conditions; and (iii) if ecological, resource, and cultural conditions are important, might we adapt this information toward greater cooperativity today? Part II investigates Girard's theory of ritual sacrifice—especially human sacrifice—as a societal steam valve for the systemic aggression explored in Part I. It draws on theories of play, theater, and art to examine the role and function of such ritual sacrifice.     

Emergent Monism and the Classical Doctrine of the Soul

Traditional Christian belief in the existence of human life after death within a transformed material universe should be capable of rational justification if one chooses carefully the philosophical scheme underlying those claims. One should not have to appeal simply to the power of a loving God to justify one's beliefs. A revision of Whitehead's metaphysical scheme is proposed that allows one to render these classical Christian beliefs at least plausible to a broad range of contemporary thinkers as a consequence of a cosmology based on the principle of universal intersubjectivity and the need for a common ground between opposing subjectivities.     

Verdi's Rigoletto: The dialectic interplay of the psychic positions in seemingly 'mindless' violence

In this paper the author demonstrates the interplay of the psychic positions (paranoid-schizoid and depressive, alongside more primitive mental states) as they may appear in experiences of overwhelming anxieties relating to fragmentation and disintegration. These are examined in relation to the appearance of what has been described in the literature as 'mindless' violence. The vehicle for this demonstration is Verdi's opera Rigoletto , which the author examines using Fonagy and Target's model for the understanding of mindless violence. The opera is 'read' as a case study of the protagonist, using the drama as a reflection of Rigoletto's internal object representations. The author attempts to extend Fonagy and Target's model to include primitive mental states, in order to understand 'mindless' violence as a result of collapse of the dialectical relationship of the psychic positions, leading to the violent act as a desperate attempt at re-establishing a sense of self. From this perspective, the moment of the violent act may be seen as use of an autistic object and as supplying of autistic shape. The violence is ultimately directed against the already fragmenting self, especially cherished parts of it, however it may enable acknowledgement of repudiated, unmentalised emotions previously experienced as a void.     

Can authorship policies help prevent scientific misconduct? What role for scientific societies?

The purpose of this article is to encourage and help inform active discussion of authorship policies among members of scientific societies. The article explains the history and rationale of the influential criteria for authorship developed by the International Committee of Medical Journal Editors, examines questions about those criteria that emerge from authorship policies adopted by several U.S. medical schools, and summarizes the arguments for replacing authorship with the contributor-guarantor model. Finally, it concludes with a plea for scientific societies to play a prominent role in the ongoing debates about authorship and the alternatives as part of their efforts to encourage ethical conduct among their members. Whether or not scientific societies develop authorship policies of their own, they should undertake vigorous educational efforts to keep their new members adequately informed about the importance of authorship practices in ethical scientific research and publication.     

Implementing ethics in the professions: Preparing guidelines on scientific communication for the Society for Neuroscience

In 1994, the governing council of the Society for Neuroscience was asked to make a brief statement on an issue regarding responsible conduct in publishing. The present article reviews how that initial request grew over the next four years into a lengthy document. Drawing on that experience, which was presided over by the author, comments are made about the potential impact of such guidelines, the lessons learned, and the proper role of professional societies in promoting responsible conduct in research.     

On the way to autonomous driving: How age influences the acceptance of driver assistance systems

Driver assistance systems have the potential to create the basis for future mobility solutions. They enable older generations in need of assistance to maintain their mobility even in the case of physical deficits. Therefore, we conducted a literature review and identified factors that may influence the acceptance of driver assistance systems. Based on the technology acceptance model and other influencing factors, we developed a research model that was validated with the help of a study (n = 227). The results show that, depending on age, there are differences in the acceptance of driver assistance systems and their influencing factors among old and young people. The five determinants of acceptance, perceived usefulness, perceived ease of use and trust in technology are viewed as equally important for all age groups. Differences emerge within the group of older vehicle drivers with varying weighting. For the 50–59 age group, perceived ease of use and social norm are most important, while for the 60–69 age group, perceived usefulness and trust in technology are very important. Among 70–90-year olds, trust in technology is emphasized as most important. Our results show how important it is to increase the confidence of older drivers in age-appropriate driver assistance systems, using target-group-specific advertising and public relations work.     

SPACE AND TIME FROM A NEO‐WHITEHEADIAN PERSPECTIVE

Russell Stannard distinguishes between objective time as measured in theoretical physics and subjective time, or time as experienced by human beings in normal consciousness. Because objective time, or four‐dimensional space‐time for the physicist, does not change but exists all at once, Stannard argues that this is presumably how God views time from eternity which is beyond time. We human beings are limited to experiencing the moments of time successively and thus cannot know the future as already existing in the same way that God does. I argue that Stannard is basically correct in his theological assumptions about God's understanding of time but that his explanation would be more persuasive within the context of a neo‐Whiteheadian metaphysics. The key points in that metaphysics are (1) that creation is contained within the structured field of activity proper to the three divine persons of the Christian doctrine of the Trinity and (2) that the spontaneous decisions of creatures are continually ordered and reordered into an ever‐expanding totality already known in its fullness by the divine persons.