胃肠道肿瘤的分子靶向治疗:未来的方向?

分子靶向治疗是这几年来消化道肿瘤治疗领域的热门话题.这类新一代的分子靶向生物治疗模式,将在临床治疗肿瘤实践中具有广阔的应用前景.从事肿瘤研究的临床医务人员需要综合归纳这些信息,融汇入自己的认知将之合理应用于患者.我们将真正进入传统的细胞毒性药物攻击与非细胞毒性靶向性药物相结合使用的时代,真正实现延长患者的生命,改善其生活质量的目标.     

海峡两岸大学生生命意义比较研究——以广州市与台中市为例

该研究以广州市与台中市大学生为被试,抽取500人为预测样本及800人为正式施测样本,通过探索性因素分析和验证性因素分析编制生命意义量表,并通过t检验和潜在剖面分析考察两岸大学生生命意义现况的差异.结果表明：（1）编制的生命意义量表由存在意义、追寻意义、存在盈实、苦难接纳、死亡接纳以及求意义的意志等6个维度组成,具有良好的信度和效度.（2）两岸大学生生命意义总体无显著差异;存在盈实、苦难接受与死亡接纳维度有显著或非常显著的差异.（3）潜在剖面分析结果显示,两岸大学生生命意义类型相似.Wald检验结果表明,对于“死亡接纳”维度,台湾与大陆学生在各潜在类别的均分上存在显著的差异.     

Impact of social support on health status and life satisfaction in people with a spinal cord injury

Abstract

Purpose: Assessment of the impact of received social support on functional health status and life satisfaction in people with spinal cord injury (SCI). Design: Respondents were 176 people with SCI between 18 and 65 years of age and living in the community. Mean time after injury was 3.6 years. Problem-oriented and emotion-oriented support, received from family members, friends and relatives, and professionals were assessed with the Sources of Social Support Inventory. Health status was assessed with the Sickness Impact Profile 68 and life satisfaction with the Life Satisfaction Questionnaire. Structural equation modelling with LISREL V8 was used to study relationships of different types and sources of social support with health status and life satisfaction.Results: Emotion-oriented support led to better psychological functioning and to greater life satisfaction. In addition, emotion-oriented support from the family led to greater satisfaction with relationships and emotion-oriented support from friends and acquaintances led to less satisfaction with social life. Problem-oriented support was not clearly related to health status and life satisfaction; there was only a negative relation between problem-oriented support and satisfaction with social life. Support, problem-oriented or emotion-oriented, from health-care professionals showed no relationships with health status or life satisfaction.Conclusions: Emotion-oriented support from family members and friends was most important for people with SCI. Greater problem-oriented support appears to be related to poorer life satisfaction.     

The choreography of everyday life—a missing brick in the general evolution theory

The “choreography of everyday life refers to the existence of rules of daily life, correspondingly to those of dances: the rules impose order upon individual behavior beyond the level of pure improvisation. The fact that acts of everyday life repeat themselves supports the idea that there exist some mechanisms generating order to daily practices. The replicative model of evolution is a candidate to explain this process of routinization. At the beginning of a replicative cycle behavioral patterns might change radically. In the course of time integrative and competitive selective forces start working. Finally some established rules, choreography, determining daily practices will emerge. In this mature phase identical replication takes place.     

Sit-to-stand movement in children: A longitudinal study based on kinematics data

Although the ability to stand from a seated posture is relevant for clinical practice, there are few studies investigating the process of acquisition and refinement of the motor components involved in sit-to-stand movement (STS) in children. Therefore, this longitudinal study aims to describe kinematic characteristics of the STS movement in children from 12 to 18 months, and also to investigate the relationship between changes in STS movement and childrens’ daily-life mobility. Ten healthy children were evaluated at 12,13,14,15 and 18 months of age. A motion analysis system was used to measure total duration of STS movement and angular movements of each joint, and frequencies of successful and unsupported STS were obtained. The Pediatric Evaluation of Disability Inventory was used to assess childrens’ daily-life mobility. Results showed that children tend to increase the frequency of successful trials over the months by reducing the total duration and decreasing peak ankle dorsiflexion and trunk flexion during STS. Children also started to stand up from chair with decreased trunk flexion angle among ages. At the end of the STS, we observed decreases in trunk flexion and knee flexion over age. Furthermore, kinematic characteristics that reflect improvements in STS movement are related to better performance of functional skills and decreased level of assistance provided by the caregiver in daily-life mobility of younger children. However, the strength of these associations decreases from 14 months of age onwards.     

Character strengths and well-being among volunteers and employees: Toward an integrative model

The endorsement and deployment of character strengths in occupational contexts are two promising components for understanding how people create well-being. In this study, a model integrating character strengths, satisfaction with occupational activities, and meaning and well-being was proposed and tested in two samples of volunteers and a sample of working adults. The model fit the data well in all three samples. Results demonstrated that deploying strengths at work provided key links to satisfaction with voluntary and paid occupational activities and to meaning among both young and middle-aged volunteers, and adult working women. Among adult volunteers and paid workers, endorsing strengths was related to meaning, while both endorsing and deploying strengths were related to well-being. Together, these studies provide a model for understanding how strengths may play a role in how both volunteer and paid workers find meaning, well-being, and satisfaction.     

Detecting and constructing meaning in life events

Three studies examined the meaning ascribed to events varying in intensity and valence and how meaning detection and construction relate to the experience of meaning in life events. In Study 1, participants were more likely to expect meaning to emerge from major life events particularly if they are negative, while trivial events were expected to be meaningful if they were positive. Study 2 showed that constructed meaning was more likely to occur in response to negative events while detected meaning was more likely to be associated with positive events. Study 3 showed that this ‘match’ between valence and meaning strategy predicted enhanced experience of meaning in those events. These studies suggest that the more subtle experience of meaning detection may provide a way to understand the meaning that emerges from positive events and experiences.     

The Imagination of Images and Images of Imagination: How the Imagination Relates to Aging,Health, and Spirituality

ABSTRACT

Psychological literature suggests that religion and spirituality increase in late adulthood. Yet, operational definitions of spirituality and religiosity remain widely debated and inadequate for the concepts they are designed to measure. The empirical studies of religion and spirituality as one ages are of poor design and often measure only limited aspects of religion or spirituality. Few empirical studies exist which have been conceived to only study religiosity and spirituality in late adulthood. The purpose of this study was to determine the defining aspects of religiosity and spirituality using the Allport, Ross Intrinsic, Extrinsic Religiosity Scale, Ellison's Spiritual Well-Being Scale, and Neugarten's Life Satisfaction Instrument. Using a principal component factor analysis, the study examined the factor structure using an older adult sample of 320 individuals 65 years of age and older. Having a purpose in life combines with intrinsic religious questions for the first factor. Life satisfaction questions group together on two factors and extrinsic religiosity is clearly one factor. The scales used hold together well when combined. A new, shortened scale to measure aspects of religiosity and spirituality is proposed.     

Setting Generalization during Self-Reinforcement with Educationally Handicapped Children

Eight educationally handicapped boys ranging in age form 10 to 11 years old and described as the worst behavior problems in their class participated in a series of single-subject studies carried out in their self-contained classrooms. Three served as target subjects, using self-reinforcement procedures to increase their sustained on-task behavior in a treatment setting; five served as generalization subjects. Data were collected in three settings within the self-contained classroom; an early morning treatment setting, a late morning generalization setting, and an afternoon generalization setting. The three target subjects averaged a 51% increase over their baseline median levels of sustained on-task behavior in the treatment setting. They averaged 84% and 96% generalization to the late morning and afternoon generalization settings, respectively. These results demonstrate that self-reinforcement can produce setting generalization of treatment effects in the absence of prior externally determined reinforcement. Evidence for subject and subject-setting generalization was also obtained.     

Understanding the relationships between age,gender, and life satisfaction: the mediating role of stress and religiosity

Although hundreds of investigations have examined the relationship between age and life satisfaction, a recent review of these studies reveals that relatively little is known about the nature of this relationship, especially between genders and across cultures, and the mechanisms that link age to life satisfaction. Using a large-scale study in Malaysia, the present research explores the mediating effects of stress and religiosity that might be responsible for the empirical findings reported in previous studies. Contrary to previous findings based on US studies, this study finds that women are more satisfied with their lives than men in the early and later stages of life. Chronic stress and religiosity were found to partially mediate the relationship between age and life satisfaction, suggesting that these may be mechanisms that explain the findings of previous studies.