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941.
942.
ROBERT ZACHARIAE 《Scandinavian journal of psychology》2009,50(6):645-651
Since the early 1980s, the interdisciplinary field of psychoneuroimmunology has explored the complex bi‐directional interactions between brain, behavior, and the immune system. Taken together, this research has expanded the limits of the questions we can ask about the organism by challenging the biomedical paradigm of the immune system as predominantly “autonomous”. Psychoneuroimmunology has played a key role in establishing a biological basis for the ancient idea that the mind can play a role in health and disease. This article describes the development of psychoneuroimmunology and reviews a number of key findings concerning psychological phenomena of potential relevance to understanding brain‐behavior‐immune interactions, including learning, emotions, stress, and the role of sensory processes. 相似文献
943.
According to the Developmental Origins of Health and Disease (DOHaD)‐hypothesis, conditions early in life may have life‐long consequences. In a series of epidemiological birth cohort and clinical studies and natural experiments, we have had the chance to test the extent to which this hypothesis is useful in understanding individual differences in psychological development and mental health. Our findings have provided evidence that individual differences in cognitive, social and emotional development and in mental health may lie in early life circumstances, and add significantly to the literature by pointing out which periods of early growth are the most critical. These findings are also important in translating pre‐clinical evidence to humans. What remains less clear, however, is what the mechanisms of programming are. Thus, further research is needed to elucidate these mechanisms before information on the early life origins of health and disease can be used in designing prevention and intervention programs. 相似文献
944.
神经肽Y是一个多肽,广泛分布于周围和中枢神经系统,以下丘脑的浓度为高,参与机体神经内分泌、情绪、行为等的调节。 为探讨慢性应激诱导的抑郁模型小鼠脑内神经肽Y (NPY)的表达,以及抗抑郁药的作用机理,采用慢性应激与孤养方法,建立抑郁小鼠模型。用旷场行为 (Open-Field)法,观察模型组与正常对照组行为学改变方面的差异。将36 只抑郁模型小鼠随机分成盐酸氟西汀组、盐酸阿米替林组、生理盐水治疗组,并与12 只正常对照组比较。用半定量逆转录-聚合酶联反应(RT-PCR) 法、细胞酶联免疫法及蛋白免疫印迹(Western-blot) 法、免疫组织化学法,比较四组小鼠下丘脑NPY 的表达。结果表明:(1)与正常组比较,抑郁模型组小鼠活动总路程与活动次数减少(p< 0.01),体重增速下降(p< 0.05)。(2)与正常组比较,抑郁模型组小鼠下丘脑NPY 的mRNA 表达下降(p< 0.01);经盐酸氟西汀、盐酸阿米替林治疗后,下丘脑NPY 的mRNA 及蛋白表达增高,与生理盐水组比较差异显著(p< 0.01)。(3) 与正常组比较,生理盐水治疗组胞膜和胞质呈棕黄色染色,显示出明显的免疫组化阳性反应;经盐酸氟西汀、盐酸阿米替林治疗后,胞膜和胞质的着色与背景色接近,免疫组化呈弱阳性、阴性反应。提示抑郁模型组小鼠脑内NPY 表达水平有显著下降,使用抗抑郁药有利于提高脑内NPY 的mRNA 及蛋白表达,可能是此类药物产生抗抑郁效应的机制之一。 相似文献
945.
Karmela Liebkind Inga Jasinskaja‐Lahti 《Journal of community & applied social psychology》2000,10(1):1-16
The aim of this study was to compare experiences of discrimination and their influence on trust in authorities and psychological distress among immigrants in Finland. A sample of 1146 immigrants, aged between 20 and 36 and representing seven immigrant groups (Russians, Ingrian/Finnish returnees, Estonians, Somalis, Arabs, Vietnamese and Turks), answered a mailed questionnaire based on traditional acculturation research as well as victim research. In accordance with our expectations, discrimination experiences in various realms of life were highly predictive of the psychological well‐being of all immigrants, as well as of lack of trust in the Finnish authorities. However, contrary to our hypotheses regarding the effects of visibility and cultural proximity, group differences in psychological distress did not correspond to the group differences observed in perceived discrimination. These results are discussed in the light of the opposing predictions concerning self‐damage effects of discrimination, made by social identity theory on the one hand and the theory on self‐protecting functions of external attributions (Crocker and Major, 1989) on the other. It is concluded that the low level of stress observed in the most visible and most culturally distant group, despite high levels of perceived discrimination, is better explained by the latter than the former. Copyright © 2000 John Wiley & Sons, Ltd. 相似文献
946.
The recommendations of a recent workshop (Leiden, Netherlands, November 17–18, 1990) concerning the use of animals in research on aggression and predation are listed. Major considerations included the grade of organisation/level of development of the organism, the duration and intensity of the interaction, post-treatment factors, the number of animals and reuse of animals. It is hoped that the recommendations will help scientists working in these areas to consider the increasingly important ethical dimension. 相似文献
947.
Long-haired rats, Rattus villosissimus, were studied in large cages. Groups of adult rats (each of 3 males, or 1 male and 2 females) were observed during intermittent encounters with a male intruder for up to 9 days. Two further groups, each of 8 males and 8 females, were maintained for 70 days without introduction of intruders. Controls were kept in small cages in which intolerant behavior was rare. Behavior during attack resembled that of male R. norvegicus, but social relationships were less stable. Only observations on males are described in detail. Some rats collapsed under attack, though unwounded, and died when not removed. Collapse occurred sometimes after a few hours, but sometimes after many days of exposure. Exposure to attack was accompanied by a decline in body weight and by some adrenal hypertrophy. Two kinds of renal pathology are described: focal glomerular hypercellularity (FGH), probably due to glomerulonephritis, and dilated distal convoluted tubules. Neither condition occurred in the controls. FGH occurred in 3 of 12 rats (25%) that remained apparently healthy during the 9 days of continuous exposure, in 21 of 23 intruders (91%) that were exposed to intermittent attack over 9 days or less without becoming debilitated, and in 8 of 11 such rats (73%) that collapsed. All rats examined from 70-day colonies had FGH, whether collapsed or not. Dilated tubules occurred in 6 of 32 intruders (19%) exposed to intermittent attack, and in 2 of 6 animals that collapsed during 70 days of exposure. Renal pathology, especially glomerulonephritis, was therefore a correlate of social intolerance; but there was no evidence that it was a significant cause of death. 相似文献
948.
本研究试图探究背景应激对应激相关大脑自发神经活动的影响。使用日常应激水平作为背景应激的量化指标,同时,使用静息态fMRI技术采集了个体在静息态下的大脑自发神经活动,并使用局部一致性(ReHo)作为指标。结果发现,背景应激越高的个体,右侧海马(扩展到丘脑和脑干)静息态下局部一致性水平越高。结果提示,经历了高背景应激的个体会表现出边缘系统脑区自发神经活动的持续活跃状态。 相似文献
949.
The current study aimed to examine the impact of maternal depression, maternal fetal attachment (MFA) and parenting stress on maternal sensitivity, intrusiveness and positive regard for the child with a sample of 36 low-income, mothers-infant dyads that were followed from pregnancy through the first year postpartum. Maternal depression and parenting stress were expected to have a negative impact on maternal sensitivity, intrusiveness and positive regard, while high MFA was hypothesized to have a positive impact on these three outcomes. Our data provide partial support for our hypotheses. Findings from this study add to the literature by examining the stability of the maternal prenatal and postpartum bond with her infant as well as by looking at the impact of parenting stress on maternal behaviors and processes that may lead to later attachment security differences, such as maternal sensitivity and responsiveness. 相似文献
950.
George A. Clum Greg A. R. Febbraro 《Journal of psychopathology and behavioral assessment》1994,16(1):69-83
This study assessed whether stress, social support, and interpersonal problem-solving appraisal/skills were predictive of level of suicidality within a chronic suicidal college sample. Stepwise regression analyses were used to assess whether stress, social support, and problem-solving were independently predictive of severity of suicide ideation. In addition, hierarchical regression analyses were used to test the mediational nature of social support and problem-solving in the stress-suicidality relationship. Problem-solving confidence was found to be a significant predictor of severity of suicide ideation. In addition, both perceived problem-solving skills and social support mediated the relationship between stress and level of suicide ideation. However, only one of the two perceived problem-solving skills interactions was in the expected direction. This study provided support for the importance of problem-solving confidence and the interaction of stress and social support in the prediction of suicide severity. Unlike previous studies, this study did not find problem-solving skills/deficits to mediate the stress-suicidality relationship.This research was supported by NIMH Grant 1-18MH48133. 相似文献