Strategic retrieval processing and the impact of knowing when a memory was first created

Retrieval orientation refers to a process where participants strategically alter how a memory cue is processed in response to different task demands. In the present study we explored whether retrieval orientation is influenced by knowing when an old stimulus was first encoded. Participants completed separate remember/know test blocks for old items from a recent delay (40 min) and old items from a remote delay (48 h). Manipulations at encoding ensured that performance levels were matched between these two blocks, thus avoiding confounds with differences in retrieval effort. Importantly, a third test block comprised old items from both delays randomly intermixed. As the nature of the old items varies unpredictably in the mixed block, it should not be possibly to adopt a specific retrieval orientation and the mixed block therefore acts as a control condition. Participants saw the words “mixed,” “recent” or “remote” prior to each test block. Comparing ERPs from the recent and remote blocks permitted an investigation of whether participants alter their retrieval orientation in response to the specific length of the retention interval. Comparing ERPs from the pure (recent and remote) test blocks to ERPs from the mixed block permitted an investigation of whether delay information per se led to differences in retrieval strategy. Analysis of the ERP data found no differences between the recent and remote blocks. However, ERPs from these pure blocks were significantly less positive than ERPs from the mixed block from 200 ms towards the end of the epoch. The findings suggest that the delay information was useful in a general sense and encouraged retrieval strategies distinct from those engaged in the mixed block. We speculate that such strategies might relate to whether or not the retrieval search is specific and constrained and/or whether processes that serve to reinstate the original encoding context are engaged.     

The Ahmadiyya and the Study of Comparative Religion in Indonesia: Controversies and Influences

As an organization of foreign origin, the existence and contribution of the Ahmadiyya in Indonesia has been a subject of debate. Some scholars ignore it completely as unimportant, while others consider that it has had significant influence. The contribution of the Ahmadiyya to Indonesian Islam most asserted by the movement itself is its efforts to check and respond to Christian missionary activity. In what way has the movement actually made a contribution to that effort? How widespread is the influence of the Ahmadiyya in the discourse on Christianity, in particular, and the study of comparative religion, in general, in Indonesia? Why has the Ahmadiyya paid more attention to the issue of Christianity than other Muslim groups? This article aims to answer these questions by analysing literature on Christianity written and distributed by the Ahmadiyya in Indonesia and the effect this has had on relations between Islam and Christianity in two fields – religious mission and academia. The article presents three propositions. First, Ahmadiyya literature, with its apologetic, polemical and controversial character, had a significant influence on the academic study of comparative religion during two periods of instability: the late colonial era and the first two decades after the declaration of independence in 1945. Second, Ahmadiyya literature on Christianity has been most influential through the way it sets out to create a sense of the superiority of Islam and its compatibility with modernity. Third, for the Ahmadiyya, the issue of Christianity, particularly the death of Jesus, has been used as evidence that Mirza Ghulam Ahmad is the second Messiah.     

肺微小浸润腺癌及浸润前病变HRCT影像特征

为总结肺微小浸润腺癌(MIA)、原位腺癌(AIS)及不典型腺瘤样增生(AAH)结节的HRCT影像特征,回顾性收集43例术前2周内行HRCT检查、经胸腔镜切除、组织病理学证实的50个肺结节,分析结节大小、成分及内部特征.结果显示所有AAH表现为纯磨玻璃结节(pGGN),且≤1.0cm,空气支气管征未见,空泡征少见;86％AIS表现为pGGN,71％的AIS≤1.0cm,且空泡征常见(相对于AAH);95％的MIA表现为混合磨玻璃结节(mGGN),其余为实性结节,90％的MIA＞1.0cm,空气支气管征常见(相对于AIS).因此结节的大小、成分、空泡征及空气支气管征在一定程度上有助于MIA、AIS及AAH的鉴别.     

纳米金材料在肿瘤诊治研究中的相关进展

目前肿瘤的早期诊断依然是需要攻克的难关,现有的抗肿瘤药物因具有较大毒性且缺乏组织特异性而存在很大的局限性.纳米金基于能够被多种基团修饰后获得对肿瘤细胞的靶向性的特点逐渐成为当前抗肿瘤研究的热点.纳米金自身具有独特的生物活性,同时具有光热效应,也可以作为载体负载药物,以上3种特点均可应用于新药物的开发,用于肿瘤诊治方面的研究.本文从这三个方面描述了近期纳米金的研究进展.     

阿尔茨海默病发病机制的研究进展

阿尔茨海默病是一种起病隐匿,进行性发展的神经系统退行性疾病。临床上以记忆障碍、失语、失用、失认、视空间损害、执行功能障碍以及人格和行为改变等全面性痴呆表现为特征,病因迄今未明,发病机制复杂。本文对可能的发病机制：遗传因素（包括ApoE基因、早老素-1和早老素-2基因,APP基因、α2巨球蛋白基因、TOMM40基因、COL25A1基因）;Aβ代谢（合成、分解、转运）;神经递质学说;自由基与氧化应激学说;金属离子学说等进行综述。     

治疼必需知痛

疼痛是人体可感知所有伤害性刺激中最难以忍受的恶性刺激,医学范畴下的疼痛是指组织损伤的前提下产生的＂躯体的不愉快的疼感觉＂加上＂与之相匹配的痛苦情感体验＂两方面内容。长期以来我们的医疗行为＂过多关注组织损伤对疼的调控、忽视了痛苦体验的人文关怀＂制约了我们服务层次。新的生物医学模式下诊疗工作强调细化疼痛分类、躯体与心理并重,以专科诊疗思路指导临床,提高医务人员对病痛的理解、引导供需匹配式的人性医疗服务是时代发展务实之举。     

L’affaire Lambert

In the case Lambert, the Council of State (high court of the Public law) finished a long trial. The question concerned the power of medical decision: family? doctor? judge? The European Court of Human Rights disputes its solution.