Neural substrates of cognitive skill learning in Parkinson's disease

While cognitive skill learning is normally acquired implicitly through frontostriatal circuitry in healthy individuals, neuroimaging studies suggest that patients with Parkinson's disease (PD) do so by activating alternate, intact brain areas associated with explicit memory processing. To further test this hypothesis, 10 patients with PD and 12 healthy controls were tested on a modified, learning version of the Tower of London task while undergoing positron emission tomography at four different time points over the course of learning. Despite having less accurate problem solving abilities than controls, PD patients were able to acquire the skill learning task. However, as compared to controls, they maintained higher levels of cerebral blood flow activity in the dorsolateral prefrontal cortex and hippocampus and showed an increase in activity in the frontopolar cortex and posterior cingulate over the course of learning. These findings reflect a shift to the explicit memory system in PD patients, enabling them to learn this cognitive skill, which is normally acquired by control subjects using implicit learning strategies and frontostriatal circuitry.     

Dimensional schizotypy,autism, and unusual word associations in artists and scientists

Studies from a range of perspectives provide evidence for a relationship between creativity and the tendency to mental illness. The present study further examined this issue by administering questionnaires measuring the minor features of psychosis and autism to 31 professional “artists” (visual artists and musicians) and 28 professional “scientists” (biological scientists and physical scientists/mathematicians). The Oxford–Liverpool Inventory of Feelings and Experiences (O–LIFE), the Hypomanic Personality Scale, and the Autism-Spectrum Quotient (AQ), were administered, in addition to a shortened form of the Kent–Rosanoff Word Association Scale. The results provided strong support for the connection of artistic creativity to positive schizotypy and hypomania and the tendency to make unusual word associations, and somewhat weaker support for the connection of scientific creativity to certain components of the autism spectrum.     

Elucidating the neural correlates of egoistic and moralistic self-enhancement

Self-enhancement is the biasing of one’s view of oneself in a positive direction. The brain correlates of self-enhancement remain unclear though it has been reported that the medial prefrontal cortex (MPFC) may be important for producing self-enhancing responses. Previous studies have not examined whether the neural correlates of self-enhancement depend on the particular domain in which individuals are enhancing themselves. Both moralistic and egoistic words were presented to participants while transcranial magnetic stimulation (TMS) was applied to the MPFC, precuneus or in a sham orientation. Participants were asked to make decisions as to the words describing themselves, some of which were positive and some of which were negative. It was found the MPFC TMS significantly disrupted egoistic self-enhancement when TMS was delivered to the MPFC. Judgments involving moralistic words were not influenced by TMS. These data provide further evidence that MPFC is involved in self-enhancement, and that the role of MPFC may be selective in this regard.     

False recognition of emotional stimuli is lateralised in the brain: An fMRI study

We have investigated whether the left (LH) and right (RH) hemisphere play a different role in eliciting false recognition (FR) and whether their involvement in this memory illusion depends on the emotional content of stimuli. Negative and neutral pictures (taken from IAPS) were presented in the divided-visual field paradigm. Subjects task was to indicate whether the pictures had already been presented or not during the preceding study phase. FR rate was much higher for the RH than the LH presentations. In line, FR resulted in activations mainly in the right prefrontal cortex (PFC) for either RH or LH presentations. Emotional content of stimuli facilitated the formation of false memories and strengthened the involvement of the right PFC in FR induction.     

On Similarity Coefficients for 2×2 Tables and Correction for Chance

This paper studies correction for chance in coefficients that are linear functions of the observed proportion of agreement. The paper unifies and extends various results on correction for chance in the literature. A specific class of coefficients is used to illustrate the results derived in this paper. Coefficients in this class, e.g. the simple matching coefficient and the Dice/Sørenson coefficient, become equivalent after correction for chance, irrespective of what expectation is used. The coefficients become either Cohen’s kappa, Scott’s pi, Mak’s rho, Goodman and Kruskal’s lambda, or Hamann’s eta, depending on what expectation is considered appropriate. Both a multicategorical generalization and a multivariate generalization are discussed.     

非语言情境中时间加工与空间距离加工的关系

时间加工与空间距离加工的关系主要有两种, 一种是在空距离–空时距以及动物的研究中, 时间加工影响空间距离加工, 空间距离加工影响时间加工, 两者相互影响, 存在对称的干扰, 这种关系与注意和记忆有关。另一种是在实距离–实时距中, 空间距离加工影响时间加工, 而时间加工不受空间距离加工的影响, 时间加工和空间距离加工之间具有不对称的干扰。时空关系的不对称与隐喻理论、人们的感知运动经验和时空信息的显著性有关。神经机制上, 右顶叶皮质、侧顶内区、左顶叶皮质、小脑、前额等参与时间加工和空间距离加工, 但两种加工涉及到的神经机制也有部分差异。未来可以从时间加工的分段性、不同条件下时间加工和空间距离加工的心理机制以及脑机制进行研究。     

Right hemisphere specialization for color detection

Three experiments were carried out to investigate hemispheric asymmetry in color processing among normal participants. In Experiment 1, it was shown that the reaction times (RTs) of the dominant and non-dominant hands assessed using a visual target presented at the central visual field, were not significantly different. In Experiment 2, RTs of ipsilateral hands to lateralized chromatic stimuli revealed that the processing time was 17 ms shorter in the right hemisphere (RH) than that in the left hemisphere among the right-handed participants, whereas no significant difference was found among the left-handed participants. On the other hand, RTs to lateralized achromatic stimuli showed no such asymmetry among both the right- and left-handed participants (Experiment 3). These findings strongly suggest RH superiority for detection of color among right-handed individuals.     

Right hemispatial neglect: frequency and characterization following acute left hemisphere stroke

The frequency of various types of unilateral spatial neglect and associated areas of neural dysfunction after left hemisphere stroke are not well characterized. Unilateral spatial neglect (USN) in distinct spatial reference frames have been identified after acute right, but not left hemisphere stroke. We studied 47 consecutive right handed patients within 48h of left hemisphere stroke to determine the frequency and distribution of types of right USN using cognitive testing and MRI imaging. The distribution of USN types was different from the previously reported distribution following acute right hemisphere stroke. In this left hemisphere stroke population, allocentric neglect was more frequent than egocentric neglect.     

Ⅰ期颈椎前后路手术治疗后纵韧带骨化症

为了探讨颈椎前后路手术治疗后纵韧带骨化症的疗效,对65例后纵韧带骨化症患者,Ⅰ期行颈椎前后路手术,采用JOA评分和X线,CT对手术效果进行评价。结果显示,按JOA标准评定,优良率为94％。术后X线及CT均示椎管有效矢状径增加,硬膜囊压迫解除。因此,颈椎前后路手术可以达到减压、稳定的目的,手术效果良好。     

A derived transfer of functions and the implicit association test

Participants were trained in a series of interrelated conditional discriminations that aimed to establish four 4-member equivalence classes (i.e., A1-B1-C1-D1, A2-B2-C2-D2, A3-B3-C3-D3, A4-B4-C4-D4). During this training, the four A stimuli (i.e., A1, A2, A3, and A4) were compounded with pictures containing positive or negative evaluative functions (A1/A2 negative & A3/A4 positive). The transfer of evaluative functions to directly and indirectly related members of the equivalence classes (i.e., B, C, and D stimuli) was measured using an Implicit Association Test (IAT). During consistent test blocks, participants were required to press the same response key for target words that were related to those A stimuli that possessed similar evaluative functions (A1/A2-left key & A3/A4-right key). During inconsistent test blocks, target words that were related to those A stimuli with different evaluative functions were assigned to the same response key (A1/A4-left key & A2/A3-right key). Results showed that all 8 participants, who passed a matching-to-sample equivalence test following the IAT, responded more rapidly on consistent relative to inconsistent test blocks. This typical IAT effect was not observed for those participants who did not pass the equivalence test. The results suggest that the IAT effect may arise from formally untested derived relations, and supports the argument that such relations could provide a valid behavioral model of semantic categories in natural language.