多巴胺系统基因对注意网络的调控作用

多巴胺是脑内重要的神经递质之一,与注意活动紧密相关。本文选取作用于突触前膜、间隙和后膜的多巴胺系统基因——多巴胺转运蛋白基因、儿茶酚氧化甲基转移酶基因和多巴胺受体基因,整合影像遗传学研究,探讨多巴胺基因对注意网络的调控。元分析发现背侧和腹侧注意网络的主要脑区均有较大的基因调控效应,且腹侧网络的效应值显著大于背侧网络,表明多巴胺系统基因在全脑范围内调控注意网络,且对腹侧网络的调控作用更强于背侧网络。     

Right-wing adherence and objective numeracy as predictors of minority group size perceptions and size threat reactions

Racial, ethnic, religious, and sexual minority populations are growing rapidly in the West. We investigate predictors and consequences of threat responses to perceived minority group size, and perceptions of minority group size itself. Study 1 (N = 274) finds that right-wing adherence predicts greater size threat, whereas lower numerical ability predicts larger perceived group size (confirmed in Studies 2–3). Study 2 (Sample 1, N = 124; Sample 2, N = 263) finds that the relation between right-wing adherence and prejudice toward minorities exhibits an indirect effect via group size threat (but not perceived size), explaining 35–66% of this relation. Study 3 (N = 310) finds a comparable indirect effect explaining 27–40% of this relation, even after statistically controlling for indirect effects of realistic, symbolic, and terroristic threat. These findings provide novel insights into psychological processes surrounding perceived minority group size, identifying size threat as especially crucial in understanding intergroup relations.     

COMT基因对注意控制神经基础的调控效应：影像遗传学研究的元分析

为探索注意控制能力个体差异的遗传来源, 当前研究主要关注儿茶酚胺氧位甲基转移酶(catechol-O-Methyltransferase, COMT)基因对参与注意控制加工的前额叶脑区的调控作用。为进一步回答COMT基因是否也对全脑范围的注意脑区具有调控作用, 本文对17篇遗传影像学研究进行元分析。结果发现, COMT基因Val/Val (vv)基因型的被试在注意控制任务下, 不仅前额叶脑区的激活水平高于Met/Met(mm)基因型的被试, 在前扣带回和后扣带回等前额叶之外的脑区激活水平也高于mm基因型的被试, 而且在这些脑区的效应值(vv>mm)都较大(Cohen’s d > 0.8)。由此, 元分析结果表明：COMT基因不仅调控前额叶脑区, 而且对形成注意控制网络的多个脑区都有调控效应。此结果提示注意控制能力的个体差异可能部分的来自于COMT基因对注意控制网络的调控作用。     

Genetic and Environmental Influences on the Development and Stability of Executive Functions in Children of Preschool Age: A Longitudinal Study of Japanese Twins

Executive functions (EF) are an important predictor of later adaptive development. A number of environmental influences, such as parenting, have been suggested as important promoters of EF development. However, behavioural genetic research has demonstrated that many environmental influences could be affected by genetic influences. Therefore, it is important to consider genetic variations when investigating environmental influences on EF development in children. To date, few studies have used genetically informative designs to assess the etiology of EF development during the preschool years, a period of rapid development. As a result, it remains unclear how and to what extent the environmental influences that are not confounded by genetic influences affect EF development during this developmental period. The present study explored EF development during the preschool years using a longitudinal and genetically informative design and a non‐Western population. Japanese twins were visited at their homes and individually tested on EF measures at 24, 36, and 48 months of age. Phenotypic correlations and confirmatory factor analyses suggested that EF are less cohesive at 24 months of age and emerge as a common single factor at 36 and 48 months. Additionally, longitudinal and multivariate behavioural genetic analyses indicated that the EF developmental change during this period is promoted by both shared and nonshared environmental influences as well as genetic influences, while EF stability is brought about by shared environments. The present findings elucidated the etiology of EF development during the preschool years and confirmed that this period is an important transitional stage for EF development. Copyright © 2016 John Wiley & Sons, Ltd.     

Identification of Genes Influencing a Spectrum of Externalizing Psychopathology

ABSTRACT— Alcohol dependence, drug dependence, childhood conduct disorder, and adult antisocial behavior commonly occur in combination. Data from multiple literatures, including twin/family studies and electrophysiological studies, suggest that the overlap of these disorders is largely due to a shared genetic liability that contributes to a spectrum of externalizing psychopathology. These findings suggest that some genes will not be specific to any one externalizing disorder but will predispose individuals broadly to a spectrum of externalizing psychopathology. Here we review evidence for specific, identified genes, GABRA2 and CHRM2 , that follow this pattern and confer risk for a spectrum of externalizing disorders. These findings confirm the etiological structure of psychopathology suggested by psychological research and suggest exciting new roles that psychologists can play in understanding the pathways underlying associations between genes and behavior.     

城市人口健康的性别差异及影响因素的实证分析

使用CHNS数据,在健康的社会分层模式下探讨城市人口健康的性别公平问题。研究认为,中国城市人口健康存在显著的性别不平等现象,男性健康水平要好于女性,而这种健康的性别差异主要是由于不同性别在社会经济地位上的差异造成的,女性处于明显的弱势地位。     

山东省人类辅助生殖技术服务利用人群特征调查研究

对山东省人类辅助生殖技术(Assisted Reproductive Techology,ART)服务利用人群特征进行了调查和评价研究.主要包括不孕症门诊病人社会学特征,知情权,不孕症患者意愿,满意度评价等;并建议进一步加大宣传教育的力度,普及ART健康知识,提高对ART的知晓率,树立正确的社会观念,达到充分有效的利用ART的目的.     

行为遗传学：从宏观到微观的生命研究

行为遗传学是在多门学科发展的基础上形成的一门交叉学科。从19世纪末期到现在,行为遗传学已跨入第三个世纪。从孟德尔单基因遗传定律到多基因系统与环境交互作用影响复杂的人类行为,从传统的计量遗传学研究到连锁、关联研究再到功能基因组学技术的应用,无论在思想体系还是研究方法上,行为遗传学都取得了突破性进展。尽管行为遗传学在阐明基因究竟怎样影响行为的道路上仍处于起步阶段,但毋庸置疑,这一学科的进步将有助于人类了解自身行为,减轻人类病痛,并最终推动整个社会健康发展。     

Genetic Studies of Autism: From the 1970s into the Millennium

Reviewers in the 1960s and early 1970s were skeptical about any substantial role for genetic factors in the etiology of autism. A realization that the 2% rate of autism in siblings (as estimated at that time) was far above the general population base rate, and that this suggested a possible high genetic liability, led to the first small-scale twin study of autism. The replicated evidence from both twin and family studies undertaken in the 1970s and 1980s indicated both strong genetic influences and the likelihood that they applied to a phenotype that was much broader than the traditional diagnostic category of autism. Medical and chromosomal findings also indicated genetic heterogeneity. Advances in molecular genetics led to genome-wide scans of affected relative pair samples with a positive log of the odds to base 10 score for a location on chromosome 7. The major remaining research challenges and the likely clinical benefits that should derive from genetic research are considered in relation to both current knowledge and that anticipated to emerge from research over the next decade.     

医学遗传服务与遗传学研究的伦理问题

遗传工程的分子技术于本世纪７０年代问世。这一技术的创新使人类与医学遗传学突飞猛进,由此导致遗传医学的飞速发展。与此同步,医学伦理学兴起,临床医学遗传服务与遗传学研究的伦理问题日益成为人文科学关注的核心。世界卫生组织（ＷＨＯ）于１９９７年发布的《医学遗传学与遗传服务伦理问题的建议国际准则》。探讨我国医学伦理学发展的策略和面临的挑战,祈盼适合我国国情的中华医学遗传服务与遗传学研究的伦理准则早日问世。