Phenotypic and genotypic heterogeneity in gaucher disease: Implications for genetic counseling

Genetic counseling for Gaucher disease is complicated by the vast degree of clinical heterogeneity encountered in the disorder. Recent advances in our understanding of the molecular genetics of Gaucher disease are particularly relevant to genetic counseling. Although the identification of mutations in the glucocerebrosidase gene has enabled genotypic screening of Gaucher patients, the ability to reliably predict patient outcome on the basis of DNA studies is often limited. An appreciation of both the spectrum of clinical manifestations in Gaucher patients and the limitations of the available genotypic information is necessary when counseling patients, families and at-risk individuals.     

Estimating the parameters of the latent population distribution

Under consideration is a test battery of binary items. The responses ofn individuals are assumed to follow a Rasch model. It is further assumed that the latent individual parameters are distributed within a given population in accordance with a normal distribution. Methods are then considered for estimating the mean and variance of this latent population distribution. Also considered are methods for checking whether a normal population distribution fits the data. The developed methods are applied to data from an achievement test and from an attitude test.     

听力正常人与聋人短时记忆的比较研究

以视觉系列呈现,自由回忆的方法比较了听力正常人与聋人对分别被强化的厂类相似性汉语字表的短时记忆获得量。从总的平均获得量来看,两组结果没有显著差异,而从每一编码维量在短时记忆的加工过程中的作用来看,两组被试都显示出了形、义两维编码维量的作用最强,而音码的作用相对比较弱。两组被试也都显示出了明显的系列位置效应,但聋人组的次级记忆容量明显地低于听力正常组,而初级记忆容量两组没有显著差异。并对可能的机制进行了讨论。     

湖南某村外出务工人员艾滋病知识掌握现状调查及分析

采取匿名问卷调查和个别深入访谈相结合的方式对103名外出务工人员进行调查,表明大部分外出务工人员对艾滋病的传播途径、预防等知识有一定了解,但是不够全面和准确,存在较多误解。今后应加大对外出务工人员的关注,采取更有效的艾滋病健康促进干预措施。     

环境因素与出生缺陷

出生缺陷是严重影响出生人口素质的重要因素之一。引起出生缺陷的因素分为遗传因素和环境因素,单纯由遗传因素或环境因素引起的出生缺陷不到其总数的1/3,另外2/3以上的出生缺陷是由遗传因素和环境因素共同作用所导致的。因此,只有不断深入研究和认识导致出生缺陷发生的原因,辩证地分析不同环境因素在出生缺陷中的作用,才能采取相应的预防和治疗措施,这对于提高出生人口素质具有十分重要的现实意义。     

Factor Structure,Validity, and Reliability of the Japanese Version of the Balanced Index of Psychological Mindedness (BIPM)

This study examined the measurement properties of the Balanced Index of Psychological Mindedness (BIPM) among the Japanese population. Exploratory factor analysis was conducted to examine the factor structure of the BIPM (Study 1) among 464 university students, and confirmatory factor analysis examined the validity and reliability of the BIPM (Study 2) among 321 university students. Additionally, the mitigation effect of psychological mindedness (PM) for depressive symptoms was examined. The results showed a two-factor structure (Interest and Insight) similar to the original BIPM. The BIPM was negatively correlated with the alexithymia score and positively correlated with the Psychological Mindedness Scale and Openness. It was also significantly correlated with future depressive symptoms. The BIPM is useful for measuring PM in the Japanese population. Additionally, this study suggests clinical applications of PM in psychotherapy and the treatment effect mechanism of cognitive behavioral therapy.     

A study of the psychometric properties of the Beck Depression Inventory‐II,the Montgomery and Åsberg Depression Rating Scale,and the Hospital Anxiety and Depression Scale in a sample from a healthy population

The objective of this study is to evaluate internal consistency and psychometric properties of the Hospital Anxiety and Depression Scale (HADS), the Beck Depression inventory‐II (BDI‐II) and the Montgomery and Åsberg Depression Rating Scale (MADRS) for screening for major depressive episode (MDE) in a selected sample from a healthy population. Participants answered the BDI‐II and the HADS questionnaires and were interviewed with MADRS. The Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders (DSM)‐IV Axis I Disorders‐Clinician Version (SCID‐CV) was used to diagnose MDE. Current MDE was diagnosed in 20 (6%) of the 357 participants. All three scales including the depression sub‐scale for HADS had high area under the receiver operating characteristics curve (ROC) (AUC) (0.84–0.87), and internal consistency was also high for all scales (0.75–0.89). Optimal cut‐off for MDE was ≥ 12 for BDI‐II, MADRS ≥ 8, HADS total ≥ 9, and HADS‐D ≥ 4, which all resulted in sensitivities = 85% and specificities > 78%. Diagnostic accuracy was low on all depression scales (Cohen's kappa = 0.20–0.40). Reports of the properties of depression scales in a healthy population are limited. We found BDI‐II, HADS and MADRS to be acceptable as screening instruments for MDE in a selected sample from healthy population with recommend cut‐offs as mentioned above.     

THEISTIC EVOLUTION IN THE POSTGENOMIC ERA

How to reconcile the theory of evolution with existing religious beliefs has occupied minds since Darwin's time. The majority of the discourse on the subject is still focused on the Darwinian version of evolutionary theory, or at best, the mid‐twentieth century version of the Modern Synthesis. However, evolutionary thought has moved forward since then with the insights provided by the advent of comparative genomics in recent decades having a particularly significant impact. A theology that successfully incorporates evolutionary biology needs to take such developments into account, because range of truly viable options among the many versions of theistic evolution that have been proposed in the past may narrow down when this is done. Here I present these previously underappreciated strains of contemporary evolutionary thought and discuss their potential theological impact.     

The Ethics of Enhanced Interrogations and Torture: A Reappraisal of the Argument

This article critically reviews what is known about the ethical status of psychologists’ putative involvement with enhanced interrogations and torture (EITs). We examine three major normative ethical accounts (utilitarian, deontic, and virtue ethics) of EITs and conclude, contra the American Psychological Association, that reasonable arguments can be made that in certain cases the use of EITs is ethical and even, in certain circumstances, morally obligatory. We suggest that this moral question is complex as it has competing moral values involved, that is, the humane treatment of detainee competes with the ethical value/duty/virtue of protecting innocent third parties. We also suggest that there is an ethical duty to minimize harm by making only judicious and morally responsible allegations against the psychologists alleged to be involved in EITs. Finally, we make recommendations regarding completing the historical record, improvements in the professional ethics code, and the moral treatment of individuals accused in this controversy.     

Ethical Considerations for Psychologists Taking a Public Stance on Controversial Issues: The Balance Between Personal and Professional Life

Previous literature has documented the general issues psychologists often face while balancing their personal and professional lives. The struggle stems from attempting to satisfy the need to maintain a life outside of work while having the professional obligation to follow the American Psychological Association’s (APA’s) Ethical Principles of Psychologists and Code of Conduct (Ethics Code) to prevent their personal lives from interfering with their professional roles and relationships. The present article analyzes the subject of psychologists taking a public position on controversial public issues. Although the APA Ethics Code does not restrict how psychologists conduct themselves during their personal time, taking a public stance on a controversial issue could potentially strain professional relationships and inadvertently reflect negatively on the profession. The present article examines ethical issues that (a) should be taken into account before psychologists take a public position on a controversial issue and (b) are in conflict with APA’s Ethics Code or current research.