Scientific Understanding and Mathematical Abstraction

This paper argues for two related theses. The first is that mathematical abstraction can play an important role in shaping the way we think about and hence understand certain phenomena, an enterprise that extends well beyond simply representing those phenomena for the purpose of calculating/predicting their behaviour. The second is that much of our contemporary understanding and interpretation of natural selection has resulted from the way it has been described in the context of statistics and mathematics. I argue for these claims by tracing attempts to understand the basis of natural selection from its early formulation as a statistical theory to its later development by R.A. Fisher, one of the founders of modern population genetics. Not only did these developments put natural selection of a firm theoretical foundation but its mathematization changed the way it was understood as a biological process. Instead of simply clarifying its status, mathematical techniques were responsible for redefining or reconceptualising selection. As a corollary I show how a highly idealised mathematical law that seemingly fails to describe any concrete system can nevertheless contain a great deal of accurate information that can enhance our understanding far beyond simply predictive capabilities.

Environmental education and socioresponsive engineering

A recent initiative at Muffakham Jah College of Engineering and Technology, Hyderabad, India, has resulted in setting up a program called Centre for Environment Studies and Socioresponsive Engineering which seeks to involve undergraduate students in studying and solving environmental problems in and around the city of Hyderabad, India. Two pilot projects have been undertaken — one focusing on design and construction of an eco-friendly house, The Natural House, and another directed at improving environmental and general living conditions in a slum area. The paper describes our attempts and experience of motivating our students to take interest in such projects. In an interesting development we invited a member of a student-faculty team at Massachusetts Institute of Technology (M.I.T.) that is doing a project in Nepal on safe drinking water. We report in our paper how the presentation by the guest from M.I.T. served as a catalyst for generating interest among civil and mechanical engineering students in our own projects. The paper includes contributions from one of our students and the M.I.T. staff member, reporting on their experiences related to the slum development project. We also discuss the Natural House project and its international and educational significance as a means of inculcating sensitivity and interest in nature among engineering students. We propose a pledge for engineers similar to the Hippocratic Oath for medical professionals.     

Biases and regularities of grapheme–colour associations in Japanese nonsynaesthetic population

Associations between graphemes and colours in a nonsynaesthetic Japanese population were investigated. Participants chose the most suitable colour from 11 basic colour terms for each of 40 graphemes from the four categories of graphemes used in the Japanese language (kana characters, English alphabet letters, and Arabic and kanji numerals). This test was repeated after a three-week interval. In their responses, which were not as temporally consistent as those of grapheme–colour synaesthetes, participants showed biases and regularities that were comparable to those of synaesthetes reported in past studies. Although it has been believed that only synaesthetes, and not nonsynaesthetes, tended to associate graphemes with colours based on grapheme frequency, Berlin and Kay's colour typology, and colour word frequency, participants in this study tended in part to associate graphemes with colours based on the above factors. Moreover, participants that were nonsynaesthetes tended to associate different graphemes that shared sounds and/or meanings (e.g., Arabic and kanji numerals representing the same number) with the same colours, which was analogous to the findings in Japanese synaesthetes. These results support the view that grapheme–colour synaesthesia might have its origins in cross-modal association processes that are shared with the general population.     

Death anxiety among New Zealanders: the predictive role of gender and marital status

The aim of this cross-sectional study was to investigate attitudes of New Zealanders towards death and dying. We administered an online version of Collett–Lester Fear of Death Scale and Concerns About Dying Instrument subscales to a representative sample of the New Zealand population. In total, 1001 people responded to the survey. Women reported more anxiousness concerning their own death (p?=?.001) and dying at a young age (p?>?.001). Women also showed more agreement towards spiritual aspects of dying (p?>?.001). Single female respondents worry more about dying (p =?.02) especially when young (p?=?.003). Single participants (p >?.001) aged 18 and 29 (p?>?.001) reported higher anxiety for Items relating to the death of others especially concerning never being able to communicate with the person again. Our findings show that marital status and gender strongly predict higher levels of death anxiety among New Zealanders. This is probably due to the cultural identity of those sampled.     

Does self-efficacy mediate the cross-sectional relationship between perceived quality of health care and self-management of diabetes? Results from Diabetes MILES – Australia

Objective: Quality of health care (QoC) and self-efficacy may affect self-management of diabetes, but such effects are not well understood. We examined the indirect role of diabetes-specific self-efficacy (DSE) and generalised self-efficacy (GSE) in mediating the cross-sectional relationship between self-reported QoC and diabetes self-management.

Design: Diabetes MILES–Australia was a national survey of 3,338 adults with diabetes. We analysed data from 1,624 respondents (age: M = 52.1, SD = 13.9) with type 1 (T1D; n = 680) or type 2 diabetes (T2D; n = 944), who responded to a version of the survey containing key measures.

Main Outcome Measures: self-reported healthy eating, physical activity, self-monitoring of blood glucose frequency, HbA_1c, medication/insulin adherence.

Results: We used Preacher and Hayes’ bootstrapping method, controlling for age, gender and diabetes duration, to test mediation of DSE and GSE on the relationship of QoC with each self-management variable. We found statistically significant but trivial mediation effects of DSE and of GSE on most, but not all, variables (all effect sizes < .06).

Conclusion: Support for mediation was weak, suggesting that relationships amongst these variables are small and that future research might explore other aspects of self-management in diabetes.     

Religiosity as a predictor of mortality: A retrospective cohort study in 1519 rural citizens in Greece

Objective: Investigating the role of religiosity in mortality.

Design: A retrospective cohort study (mean follow-up period 131.2 ± 30.8 months) in 1519 rural citizens in Greece (57.1% women, mean age 56.9 ± 20.4 years).

Main outcome measures: Measurements included education, disease status, body mass index, lifestyle, sleep-quality and self-rated health (SRH). Religiosity was assessed as composite score of praying and church attendance. Cox proportional hazard models were used to calculate adjusted hazard ratios (aHR) for all-cause and cardiovascular mortality.

Results: A total of 293 deaths were recorded, 59.2% of which had occurred due to cardiovascular diseases, followed by cancer diseases (17%). All-cause mortality was found increased for older people (aHR: 1.10, 95%CI: 1.08–1.11, p < .0001), for males (aHR: 1.44, 95%CI: 1.14–1.83, p = .002), for people reporting good SRH (aHR: .66, 95%CI: .51–.87, p = .003). Moreover, with increasing age the practice of regular exercise decreases all-causes mortality by approximately 3.5% by each year. Participants in the moderate category of religiosity were found to have decreased risk for all-cause mortality (aHR: .61, 95%CI: .46–.83, p = .001) compared to those in the low religiosity category. Cardiovascular mortality was also significantly associated with SRH and religiosity.

Conclusion: Religiosity predicts mortality, in a rural population in Greece. Deciphering the mediators of religiosity and mortality relationship could facilitate future health policies.     

Repeated challenge studies: A comparison of union-intersection testing with linear modeling

Challenge studies are often implemented for assessing whether a subject is sensitive to a certain agent or allergen. In particular, researchers test groups of subjects to determine if there really exists a causal relationship between some agent of interest and a response. To answer such a question, we need to detect the presence of the phenomenon in just one individual. Typically, however, there are a large number of unknown risk factors associated with the response and a potentially small population prevalence. Hence, standard statistical techniques, by averaging the treatment effect across the group, may miss a significant response of a single individual and lead to inconclusive results. We develop an alternative approach based on union-intersection testing that will allow a practitioner to correctly examine observations on an individual apart from the other subjects and test the hypothesis of interest: Does the phenomenon exist in the population? More specifically, we show how this technique adjusts for the multiple number of tests encountered when analyzing data for each individual subject separately. Furthermore, we demonstrate power calculations for the determination of sample size prior to performing the study. The performance of the union-intersection approach in comparison to linear models and semiparametric techniques is considered through sample size calculations and simulations. The union-intersection testing methodology out performs the Kolmogorov tests. However, the nested linear model performs as well if not better than the union-intersection tests. To illustrate the ideas presented in the paper, we provide an application in which we analyze psychological data collected by way of a challenge study design.     

Ambiguity, trust, and the responsible conduct of research

Ambiguity associated with everyday practice of science has made it difficult to reach a consensus on how to define misconduct in science. This essay outlines some of the important ambiguities of practice such as distinguishing data from noise, deciding whether results falsify a hypothesis, and converting research into research publications. The problem of ambiguity is further compounded by the prior intellectual commitments inherent in choosing problems and in dealing with the skepticism of one's colleagues. In preparing a draft code of ethics for the American Society of Biochemistry and Molecular Biology (ASBMB), an attempt was made to take into account the ambiguities of practice. Also, the draft code adopted trust as its leading principle, specifically the importance of trust as a condition necessary for there to be science. During revision of the code, the focus on trust was changed. The new orientation was on trust as a consequence of carrying out science responsibly. By addressing the obligations necessary to engender trust, the ASBMB ethics code not only sets professional standards, but also makes a clear statement of public accountability.     

An explication of the National Society of Genetic Counselors (NSGC) code of ethics

This article reviews the work carried out by the NSGC ad hoc Committee on Ethical Codes and Principles between 1986 and 1991 and serves as a guide for interpreting the NSGC Code of Ethics. The NSGC Code of Ethics is written from the ethic of care perspective. It is based on the responsibilities that arise from the four primary relationships genetic counselors experience in their work: genetic counselors and themselves, their clients, their colleagues, and society. The values selected for each relationship and the resultant guidelines are explained. The Code of Ethics became effective January 1, 1992.