Attitudes toward genetic counseling and prenatal diagnosis among a group of individuals with physical disabilities

Few studies have been published on the attitudes of people with physical disabilities toward genetic counseling and prenatal diagnosis. Articles in the lay press and social science literature on this topic, mainly written by disability rights activists and advocates, imply opposition to prenatal diagnosis and the field of clinical genetics by the physically disabled population. In this study, 15 adults with physical disabilities were interviewed regarding their attitudes toward genetic counseling and prenatal diagnosis. Genetic counseling and prenatal diagnosis were generally viewed favorably by this sample of the disability community. Only a small percentage of the sample perceived genetics to be eugenic. Implications for genetic counseling and future research are discussed.     

Evolving research misconduct policies and their significance for physical scientists

Scientific misconduct includes the fabrication, falsification, and plagiarism (FFP) of concepts, data or ideas; some institutions in the United States have expanded this concept to include “other serious deviations (OSD) from accepted research practice.” It is the absence of this OSD clause that distinguishes scientific misconduct policies of the past from the “research misconduct” policies that should be the basis of future federal policy in this area. This paper introduces a standard for judging whether an action should be considered research misconduct as distinguished from scientific misconduct: by this standard, research misconduct must involve activities unique to the practice of science and must have the potential to negatively affect the scientific record. Although the number of cases of scientific misconduct is uncertain (only the NIH and the NSF keep formal records), the costs are high in terms of the integrity of the scientific record, diversions from research to investigate allegations, ruined careers of those eventually exonerated, and erosion of public confidence in science. Existing scientific misconduct policies vary from institution to institution and from government agency to government agency; some have highly developed guidelines that include OSD, others have no guidelines at all. One result has been that the federal False Claims Act has been used to pursue allegations of scientific misconduct. As a consequence, such allegations have been adjudicated in federal courts, rather than judged by scientific peers. The federal government is now establishing a first-ever research misconduct policy that would apply to all research funded by the federal government regardless of which agency funded the research or whether the research was carried out in a government, industrial or university laboratory. Physical scientists, who up to now have only infrequently been the subject of scientific misconduct allegations, must nonetheless become active in the debate over research misconduct policies and how they are implemented since they will now be explicitly covered by this new federal wide policy. Disclaimer: The authors are grateful for the support for conduct of this research provided by the United States Department of Energy (DOE). The views expressed in this paper are solely those of the authors and were formed and expressed without reference to positions taken by DOE or the Pacific Northwest National Laboratory (PNNL). The views of the authors are not intended either to reflect or imply positions of DOE or PNNL.     

Reasoning with Factors

The paper proposes an analysis and a formalisation of factor-based reasoning. After examining the relevance of factors in legal reasoning, binary and scalable factors (dimensions) are distinguished and the relations between them are discussed. An account of a fortiori reasoning with both types of factors is developed. This article reports ideas which are discussed and developed in Sartor (2005). We refer to the latter work for the theoretical framework in which our analysis of factors is embedded.     

Effect of Children's Perceived Rejection on Physical Aggression

This study investigated whether the perception of self as socially rejected might contribute to increased physical aggression among elementary-school children. It was hypothesized that physically aggressive children would become more physically aggressive over time if they perceived that they were rejected and tended to blame peers for social failure experiences. Third-grade boys and girls (n = 941) were assessed in the Fall and Spring of the school year. Peer-report data on physical aggression and social preference were collected, along with self-report data on perceived rejection and attributions for social failure experiences. Results for boys were consistent with hypotheses, whereas the results for girls revealed a different pattern of relations. These results constitute prospective evidence that children's self-perceptions of social rejection can uniquely influence externalizing behavior. Results are discussed in terms of mechanisms that might mediate the relation between perceived rejection and physical aggression.     

A formal model for structuring local perceptions of environmental space

The problem of constructing computational models of space that mimic those found in human spatial reasoning is addressed. This paper extends a formal model that addressed point objects in a 2D world to include the presence of line objects and barriers. The problem consists of determining an appropriate global model for the spatial configuration given a sequence of local views or observations. A formal model is proposed based on constraint network theory. The model leads to the identification of stable regions within which perceptual information about the environment changes slowly, and zones of transition within which the perceptual information changes more quickly. A special case of transition zones is a gateway, which may be viewed as a kind of discontinuity or singularity in the model. It is expected that the model obtained will be used to mimic human mental representations of navigable outdoor environments.     

Perseverative responding in a violation-of-expectation task in 6.5-month-old infants

In the present research, 6.5-month-old infants perseverated in a violation-of-expectation task designed to examine their reasoning about width information in containment events. After watching a familiarization event in which a ball was lowered into a wide container, the infants failed to detect the violation in a test event in which the same ball was lowered into a container only half as wide as the ball (narrow-container test event). This negative result (which was replicated in another experiment) was interpreted in terms of a recent problem-solving account of infants' perseverative errors in various means-end tasks (Aguiar, A., & Baillargeon, R. (2000). Perseveration and problem solving in infancy. In H. W. Reese (Ed.), Advances in child development and behavior (Vol. 27, pp. 135-180). San Diego, CA: Academic Press). It was assumed that the infants in the present experiments (1) did not attend to the relative widths of the ball and container in their initial analysis of the narrow-container test event, (2) categorized the event as similar to the familiarization event shown on the preceding trials, and (3) retrieved the expectation they had formed for that event ("the ball will fit into the container"), resulting in a perseverative error. This interpretation was supported by additional experiments in which different modifications were introduced that led to non-perseverative responding, indicating that 6.5-month-old infants could detect the violation in the narrow-container test event. The present findings are important for several reasons. First, they provide the first demonstration of perseverative responding in a violation-of-expectation task. Second, they make clear the breadth and usefulness of the problem-solving account mentioned above. Finally, they add to the evidence for some degree of continuity between infants' and adults' problem-solving abilities.     

An evidential support accumulation model of subjective probability

A model of cue-based probability judgment is developed within the framework of support theory. Cue diagnosticity is evaluated from experience as represented by error-free frequency counts. When presented with a pattern of cues, the diagnostic implications of each cue are assessed independently and then summed to arrive at an assessment of the support for a hypothesis, with greater weight placed on present than on absent cues. The model can also accommodate adjustment of support in light of the baserate or prior probability of a hypothesis. Support for alternatives packed together in a "residual" hypothesis is discounted; fewer cues are consulted in assessing support for alternatives as support for the focal hypothesis increases. Results of fitting this and several alternative models to data from four new multiple-cue probability learning experiments are reported.     

Reasoning with quantifiers

In the semantics of natural language, quantification may have received more attention than any other subject, and one of the main topics in psychological studies on deductive reasoning is syllogistic inference, which is just a restricted form of reasoning with quantifiers. But thus far the semantical and psychological enterprises have remained disconnected. This paper aims to show how our understanding of syllogistic reasoning may benefit from semantical research on quantification. I present a very simple logic that pivots on the monotonicity properties of quantified statements--properties that are known to be crucial not only to quantification but to a much wider range of semantical phenomena. This logic is shown to account for the experimental evidence available in the literature as well as for the data from a new experiment with cardinal quantifiers ("at least n" and "at most n"), which cannot be explained by any other theory of syllogistic reasoning.     

What response times tell of children's behavior on the balance scale task

Analysis of accuracy of responses to balance scale problems gives a global idea of the cognitive processes that underlie problem-solving behavior on this task. We show that response times (RTs) provide additional detailed information about the kind and duration of these processes. We derive predictions about the RTs from Siegler's (1981) model for the balance scale task, including the counterintuitive prediction that young adults are slower than children in solving particular balance scale problems. The predictions were tested in a study in which 191 6- to 22-year-old participants were presented with a computerized balance scale task. RTs were analyzed with regression models. In addition to qualitative differences between items, we also modeled quantitative differences between items in the regression models. Analyses supported the predictions and provided additional knowledge on the rules. Rule II was reformulated as a rule that always involves the encoding, but not always the correct application of the distance cue. RTs provided evidence for the use of a buggy-rule and not an addition-rule. Finally, a relation between rule inconsistency and increased RT was found.