Association of polymorphisms in BDNF, MTHFR, and genes involved in the dopaminergic pathway with memory in a healthy Chinese population

The contribution of genetic factors to the memory is widely acknowledged. Research suggests that these factors include genes involved in the dopaminergic pathway, as well as the genes for brain-derived neurotrophic factor (BDNF) and methylenetetrahydrofolate reductase (MTHFR). The activity of the products of these genes is affected by single nucleotide polymorphisms (SNPs) within the genes. This study investigates the association between memory and SNPs in genes involved in the dopaminergic pathway, as well as in the BDNF and MTHFR genes, in a sample of healthy individuals. The sample includes 134 Taiwanese undergraduate volunteers of similar cognitive ability. The Chinese versions of the Wechsler Memory Scale (WMS-III) and Wechsler Adult Intelligence Scale (WAIS-III) were employed. Our findings indicate that the BDNF Met66Val polymorphism and dopamine receptor D3 (DRD3) Ser9Gly polymorphism are associated significantly with long-term auditory memory. Further analysis detects no significant associations in the other polymorphisms and indices. Future replicated studies with larger sample sizes, and studies that consider different ethnic groups, are encouraged.     

工作记忆对时间加工的影响

非时间信息加工与时间加工的关系是复杂的, 存在双向干扰或单向干扰, 结果的不一致与任务所需的注意资源及工作记忆都有关。工作记忆的中央执行系统在时间加工中起主要作用, 同时进行的非时间任务对中央执行功能的需求越多, 两种任务之间的干扰程度越大。语言环和视空间模板对时间加工的影响与非时间信息的类型有关。工作记忆作为一个整体以工作记忆容量为指标, 计时成绩也表现出与工作记忆容量有关的年龄、智力等方面的差异。时间加工和工作记忆在额叶、顶叶、基底神经节等皮质存在共同的神经机制。未来应该丰富工作记忆的研究内容, 结合时间加工的分段性探讨工作记忆影响时间加工的具体进程及神经机制, 并力求在应用方面取得一定的成果。     

舌尖效应产生和解决的词汇提取年老化机制：两阶段范式研究

舌尖效应年老化机制受语言特异性因素的影响。本研究把Stroop效应作为协变量,在统计分析控制个体抑制能力的基础上,采用两阶段范式考察舌尖效应产生和解决过程中词汇提取的年老化机制。结果发现：（1）老年人的舌尖效应产生率和语音提取缺陷均显著高于青年人,而语义提取缺陷的年龄差异不显著;（2）老年人的舌尖效应解决率和语音促进效应量均显著低于青年人;（3）语义启动影响老年人舌尖效应解决时的语言促进效应,而对青年人没有影响。上述结果表明,舌尖效应产生和解决的词汇提取年老化与语音提取衰退有关,与语义提取衰退无关,支持语言特异性衰退的观点。     

任务数量与工作记忆容量对交错学习的影响

研究以分子结构式为材料,让被试在单任务或双任务条件下以集中呈现和交错呈现的方式进行学习,并通过操作广度、旋转广度和对称广度任务测量工作记忆容量（working memory capacity, WMC）,探究在基于规则类别学习中交错呈现优势的稳定性。结果显示,交错呈现优势仅体现在文科生中;而对于理科生,集中呈现效果较佳。另外,任务数量和WMC均不影响交错呈现优势,表明交错呈现优势稳定存在于单任务和双任务条件中,且不同WMC的个体均能从交错学习获益。     

现实场景典型空间位置关系客体的解码效应

通过探讨典型空间关系客体对中单个客体的视觉工作记忆,考察空间位置关系的解码特征和主动客体记忆优势。结果发现：（1）当客体以符合空间位置关系方式呈现时,记忆更准确;（2）符合空间位置关系条件下单个客体提取反应时更长,上方客体反应时更短,记忆更准确;（3）兼具空间位置关系与动作关系客体对中的主动客体记忆正确率更高。结果表明,现实场景客体空间分组中单个客体提取时存在解码现象和顺序效应,对现实中的上方与主动客体存在加工偏好。     

Dorsolateral prefrontal cortex mediates working memory processes in motor skill learning

Neuroimaging studies have shown that the dorsolateral prefrontal cortex (DLPFC) is recruited during motor skill learning, which suggests the involvement of the DLPFC in working memory (WM) processes, such as selection and integration of motor representations temporarily stored in WM. However, direct evidence linking activation of the DLPFC to WM storage and manipulation during motor skill learning in real-time is rare. In this study, we conducted two experiments to investigate the causal role of DLPFC activity in WM storage and manipulation during motor skill learning under low and high WM-demand conditions. Participants received continuous theta burst stimulation (cTBS) and sham stimulation (crossover design) over the left DLPFC (experiment 1) or right DLPFC (experiment 2). Before and after stimulation, participants in both experiments performed a sequential finger-tapping (SFT) task containing repeated sequence (low-WM demand) and non-repeated sequence (high-WM demand) conditions which are used to study WM processes. The number of correct sequences (NoCS) and reproduction error rate were analyzed. Learning gains in NoCS improved significantly with the practice for both sequence types in the presence of either stimulation type. Compared to sham stimulation, cTBS over the left DLPFC resulted in significantly reduced learning gains in NoCS for non-repeated sequences. These results suggest that the left DLPFC contributes to WM manipulation during motor skill learning.     

Adults who are more anxious and were anxiously attached as children report later first memories

Here, we examined retrospective reports of adults’ earliest autobiographical memory, the age of this report and whether the reported age was associated with exposure to early life adversity, current anxiety and childhood attachment. Across four studies, we found that reporting a later ‘earliest’ memory was associated with higher self-reported anxiety in both American (Studies 1, 2 and 4) and Australian (Study 3) samples. Furthermore, in Studies 2–4, we found that reporting a later earliest memory uniquely predicted anxiety when controlling for number of adverse childhood events (a risk factor for the development of anxiety). In Study 4, we established that this relation is partially mediated by childhood anxious attachment. Although we consistently demonstrated that later earliest memories were associated with current anxiety, we found little evidence for a relation between reported age at the time of earliest memory and childhood adversity. We also found no evidence of gender differences in the associations of interest. These results suggest that poorer memory of early childhood is associated with greater childhood anxious attachment and anxiety in adulthood. The implications of this work are discussed in terms of the adaptive nature of autobiographical memory and the development of a coherent life narrative.     

Sex differences in the association of math achievement with visual-spatial and verbal working memory: Does the type of math test matter?

Previous research on sex differences in mathematical achievement shows mixed findings, which have been argued to depend on types of math tests used and the type of solution strategies (i.e., verbal versus visual-spatial) these tests evoke. The current study evaluated sex differences in (a) performance (development) on two types of math tests in primary schools and (b) the predictive value of verbal and visual-spatial working memory on math achievement. Children (N = 3175) from grades 2 through five participated. Visual-spatial and verbal working memory were assessed using online computerized tasks. Math performance was assessed five times during two school years using a speeded arithmetic test (math fluency) and a word problem test (math problem solving). Results from Multilevel Multigroup Latent Growth Modeling, showed that sex differences in level and growth of math performance were mixed and very small. Sex differences in the predictive value of verbal and visual-spatial working memory for math performance suggested that boys seemed to rely more on verbal strategies than girls. Explanations focus on cognitive and emotional factors and how these may interact to possibly amplify sex differences as children grow older.     

Impaired semantic memory during acute transient global amnesia

As a clinical model of hippocampal dysfunction, transient global amnesia (TGA) causes reversible memory disturbance. While episodic memory deficits in TGA patients have been extensively described, data regarding semantic memory involvement are sparse and contradictory. We report impaired semantic fluency performance in 16 patients with hippocampal lesions on MRI during acute TGA compared to their performance one day later and to that of 20 healthy subjects. Our findings support the involvement of the hippocampus in semantic retrieval.     

不稳定控制感剥夺损害工作记忆刷新功能

控制感剥夺会阻碍工作记忆中的转换功能,但对工作记忆中刷新功能的影响机制尚不清楚。据此,本文通过两个实验来探究控制感剥夺对工作记忆刷新功能的影响。结果发现,相较于基线水平,无论是通过行为无助任务（实验1）还是通过信息无助任务（实验2）操纵的稳定控制感剥夺均未阻碍随后的刷新任务;但在不稳定控制感剥夺的条件下（实验2）,刷新任务的成绩显著降低。这表明,控制感剥夺对工作记忆刷新功能的影响依赖于对其操纵的稳定性。