Neuroticism and extraversion share genetic and environmental effects with negative and positive mood spillover in a nationally representative sample

Work-family spillover research focuses on how negative and positive moods in one life domain carry over to another. Domain-specific etiologies (e.g., family conflict) are often emphasized to explain spillover. Yet, strong correlations exist between spillover variables of the same emotional valence but originating from different domains, suggesting individual differences in the tendencies to prolong mood-states. The current study (N = 1143 individuals) examined whether these general tendencies are associated with neuroticism and extraversion and how genetic and environmental effects contribute to these associations. Findings revealed that neuroticism and extraversion are related to these tendencies through both genetic and environmental pathways.     

Pharmacological treatment effects on eye movement control

The increasing use of eye movement paradigms to assess the functional integrity of brain systems involved in sensorimotor and cognitive processing in clinical disorders requires greater attention to effects of pharmacological treatments on these systems. This is needed to better differentiate disease and medication effects in clinical samples, to learn about neurochemical systems relevant for identified disturbances, and to facilitate identification of oculomotor biomarkers of pharmacological effects. In this review, studies of pharmacologic treatment effects on eye movements in healthy individuals are summarized and the sensitivity of eye movements to a variety of pharmacological manipulations is established. Primary findings from these studies of healthy individuals involving mainly acute effects indicate that: (i) the most consistent finding across several classes of drugs, including benzodiazepines, first- and second- generation antipsychotics, anticholinergic agents, and anticonvulsant/mood stabilizing medications is a decrease in saccade and smooth pursuit velocity (or increase in saccades during pursuit); (ii) these oculomotor effects largely reflect the general sedating effects of these medications on central nervous system functioning and are often dose-dependent; (iii) in many cases changes in oculomotor functioning are more sensitive indicators of pharmacological effects than other measures; and (iv) other agents, including the antidepressant class of serotonergic reuptake inhibitors, direct serotonergic agonists, and stimulants including amphetamine and nicotine, do not appear to adversely impact oculomotor functions in healthy individuals and may well enhance aspects of saccade and pursuit performance. Pharmacological treatment effects on eye movements across several clinical disorders including schizophrenia, affective disorders, attention deficit hyperactivity disorder, Parkinson’s disease, and Huntington’s disease are also reviewed. While greater recognition and investigation into pharmacological treatment effects in these disorders is needed, both beneficial and adverse drug effects are identified. This raises the important caveat for oculomotor studies of neuropsychiatric disorders that performance differences from healthy individuals cannot be attributed to illness effects alone. In final sections of this review, studies are presented that illustrate the utility of eye movements for use as potential biomarkers in pharmacodynamic and pharmacogenetic studies. While more systematic studies are needed, we conclude that eye movement measurements hold significant promise as tools to investigate treatment effects on cognitive and sensorimotor processes in clinical populations and that their use may be helpful in speeding the drug development pathway for drugs targeting specific neural systems and in individualizing pharmacological treatments.     

Biological Implications of Gene–Environment Interaction

Gene–environment interaction (G × E) has been treated as both a statistical phenomenon and a biological reality. It is argued that, although there are important statistical issues that need to be considered, the focus has to be on the biological implications of G × E. Four reports of G × E deriving from the Dunedin longitudinal study are used as exemplars of the biological considerations that should lead to an hypothesis-driven choice of the specific genetic polymorphisms and the specific environmental influence to be investigated. The same four studies are used to discuss how the assessment of internal and external validity can be undertaken and how experimental approaches in humans and with animal models may be informative in the elucidation of the relevant operative biological mechanisms.     

Children’s Affect Expression and Frontal EEG Asymmetry: Transactional Associations with Mothers’ Depressive Symptoms

Although parents and children are thought to influence one another's affect and behavior, few studies have examined the direction of effects from children to parents, particularly with respect to parental psychopathology. We tested the hypothesis that children's affective characteristics are associated with the course of mothers' depressive symptoms. Children's affect expression was observed during a series of mother-child interaction tasks, and children's resting frontal electroencephalogram (EEG) asymmetry was assessed in a psychophysiology laboratory. Mothers' depressive symptoms were assessed at two time points, approximately one year apart, at the mother-child interaction visits. Depressive symptoms increased over time for mothers with a history of childhood-onset depression whose children exhibited right frontal EEG asymmetry. Depressive symptoms were associated with high child negative affect at both time points for mothers whose children exhibited right frontal EEG asymmetry. Cross-lagged models with a subset of participants provided some evidence of both parent-to-child and child-to-parent directions of effects. Findings suggest that akin to other interpersonal stressors, children's affective characteristics may contribute to maternal depressive symptoms.     

社会认知中的样例激活效应与内-外群体效应

采用信号检测论技术,以人格词单记忆为实验任务,探讨社会认知过程中样例激活效应与内-外群体效应对记忆过程的干扰作用.实验结果表明,(1)样例激活与群体范畴的交互效应对社会信息加工过程存在显著干扰作用.(2)与外群体相比,内群体的信息加工更不易受到干扰;与积极样例特质相比,消极他相关样例特质的信息加工更不易受到干扰.(3)在加工内群体成员信息而激活的是反面样例时,被试的判断标准最严.     

简单结构刺激非规则特征突显条件下的样例效应

用变化了的Allen和Brooks的实验范式,采用2(学习轮次:5轮、10轮)×2(项目类型:旧项目、新项目)×2(项目匹配性质:正向匹配、反向匹配)混合实验设计,研究对4个特征刺激分类时非规则特征突显条件下的样例效应。结果发现,无论是错误率还是反应时都取得了明显的样例效应,但是学习时间的影响不明显。     

Automatic processing of pain: the change of implicit pain associations after psychotherapy

This study explores the utility of a pain IAT for the assessment of dysfunctional cognitive beliefs in chronic pain patients before and after a cognitive behaviour therapy. A patient group suffering from chronic pain (N=25) treated with a 4-week cognitive behavioural psychotherapy is compared with an untreated healthy control group (N=27) at two points in time. In addition, both groups completed a self-esteem questionnaire (Rosenberg-scale) and a self-esteem IAT. In the clinical group a questionnaire assessing self-reported pain cognitions was administered. The pain IAT was able to differentiate between chronic pain patients and healthy controls before the treatment. Most important, pain-related implicit associations could be shown to change over the course of treatment in the clinical group of chronic pain patients. Results provide first evidence for an application of the IAT in chronic pain research.     

Testing boundary conditions for the conjunction fallacy: effects of response mode, conceptual focus, and problem type

Two experiments used within-subject designs to examine how conjunction errors depend on the use of (1) choice versus estimation tasks, (2) probability versus frequency language, and (3) conjunctions of two likely events versus conjunctions of likely and unlikely events. All problems included a three-option format verified to minimize misinterpretation of the base event. In both experiments, conjunction errors were reduced when likely events were conjoined. Conjunction errors were also reduced for estimations compared with choices, with this reduction greater for likely conjuncts, an interaction effect. Shifting conceptual focus from probabilities to frequencies did not affect conjunction error rates. Analyses of numerical estimates for a subset of the problems provided support for the use of three general models by participants for generating estimates. Strikingly, the order in which the two tasks were carried out did not affect the pattern of results, supporting the idea that the mode of responding strongly determines the mode of thinking about conjunctions and hence the occurrence of the conjunction fallacy. These findings were evaluated in terms of implications for rationality of human judgment and reasoning.     

The turban effect: The influence of Muslim headgear and induced affect on aggressive responses in the shooter bias paradigm

Does Islamic appearance increase aggressive tendencies, and what role does affect play in such responses? In a computer game, participants made rapid decisions to shoot at armed people, some of whom wore Islamic head dress. We predicted and found a significant bias for participants to shoot more at Muslim targets. We also predicted and found that positive mood selectively increased aggressive tendencies towards Muslims, consistent with affect-cognition theories that predict a more top-down, stereotypical processing style in positive mood. In contrast, induced anger increased the propensity to shoot at all targets. The relevance of these results for our understanding of real-life negative reactions towards Muslims is discussed, and the influence of affective states on rapid aggressive responses is considered.