Funding,objectivity and the socialization of medical research

There has been a sharp rise in private funding of medical research, especially in relation to patentable products. Several serious problems with this are described. A solution involving the elimination of patents and public funding administered through extended national health care systems is proposed. An earlier version of this paper was presented at an International Conference on “Conflict of Interest and its Significance in Science and Medicine” held in Warsaw, Poland on 5–6 April, 2002.     

A review of climate and culture research in selling and sales management

Despite the extensive literature on organizational climate and culture and their impact on an organization's sales activities, the diversity of theoretical perspectives makes it difficult for sales professionals and scholars to understand the effect of specific climate- and culture-related factors on the performance of salespeople and sales units in an organization. The objective of this article is to clarify the conceptual underpinnings of organizational climate and culture research within the sales context through an extensive review of extant literature. In doing so, we offer a critical review of research on organizational climate and culture, a conceptual frame for viewing the literature across different levels of analysis, and specific questions to guide future research. We also make a case for more research on industry-level climate and culture in the sales context.     

员工情绪智力与主观幸福感:获益支持与情绪劳动策略的中介作用

运用情绪智力问卷、主观幸福感问卷、获益支持问卷以及情绪劳动策略问卷对400名服务行业员工进行施测,建立结构方程模型以探讨获益支持及情绪劳动策略在情绪智力对主观幸福感影响中的中介作用。研究发现:(1)服务行业员工情绪智力处于中等水平,主观幸福感处于中等偏上水平;(2)员工情绪智力,获益支持、情绪劳动策略及主观幸福感之间两两相关;(3)获益支持与情绪劳动策略在员工情绪智力与主观幸福感之间起中介作用。     

A multicriteria approach for material yard planning

The material yard is the origin of the production process for manufacturing firms. If materials are not stored at appropriate locations of the yard, then the stacking operation and the subsequent reclaiming operation will be inefficient in terms of time. In this paper a multicriteria approach which utilizes local trade-offs between different criteria in the absence of an explicit overall preference function is proposed to solve the material yard planning problem. The idea is to linearize the unknown preference function at a given point in the solution space. If the trade-offs between different criteria at this point can be determined via some mechanism, then a better solution can be derived. This process is continued until it converges to a stationary point, namely the optimal solution. To illustrate this idea, a case of the China Steel Co. in Taiwan is presented. The results from a simulation study indicate that the proposed approach is able to find a very good solution which satisfies all the criteria in a rather short transition period. © 1997 John Wiley & Sons, Ltd.     

Ethical Guidance for Selecting Clinical Trials to Receive Limited Space in an Immunotherapy Production Facility

Our aims are to (1) set forth a multiprinciple system for selecting among clinical trials competing for limited space in an immunotherapy production facility that supplies products under investigation by scientific investigators; (2) defend this system by appealing to justice principles; and (3) illustrate our proposal by showing how it might be implemented. Our overarching aim is to assist manufacturers of immunotherapeutic products and other potentially breakthrough experimental therapies with the ethical task of prioritizing requests from scientific investigators when production capacity is limited.     

谈合理用药的相对性

合理或不合理用药是相对的,在临床工作中不能绝对化。首先,合理用药的目的是相对的,安全、有效、经济很难完全满足。其次,合理用药要求的内容是相对的,对于一个具体患者,药物治疗要符合病情、患者和药学的全部特点并非易事。再者,判断合理用药与否的主要依据(如临床资料、临床试验结果等)的可靠性或可信性也不是绝对的。最后必须指出,合理用药的结果受到诸多因素的影响,不一定理想,不一定令人满意。在临床工作中,应尽可能避免不合理用药,若无法避免,可先评估得失和权衡利弊,然后做出科学决策,并加强药学监护和医患沟通。     

Healthy Children As Subjects in Pharmaceutical Research

Recruitment of healthy children for drugresearch has emerged due in part to several newAmerican laws and policies that have led to asurge in pharmaceutical research involvingchildren-subjects. In this paper, I review theethical and scientific issues and the argumentsin favor and against this new practice.     

Friend or foe: A brief examination of the ethics of corporate sponsored research at universities

In his paper entitled “Ethics and the Funding of Research and Development at Universities”¹ Spier examines some of the potential problems of the relationship between 1) corporate sponsors of research and 2) the universities (and faculty) that receive that funding. Citing “He who pays the piper, calls the tune,” Spier suggests that a better way of funding research would be to “set up a dedicated publicly sponsored research establishment” with the stated goal of achieving particular technical or engineering objectives. (Spier cited the successful Animal Virus Research of the UK as an example). Spier states that researchers at these establishments are “not subjected to the triple requirement to teach, research and administer as are university members, so they do not have to face the same ethical challenges of the academics.” This paper will examine the stated dangers of public/corporate research partnerships and whether the proposed alternative shares equally troubling ethical issues.     

轻工企业组织行为与经济绩效的实证研究

为了探索中国轻工企业组织行为与经济绩效的因果关系和操作模式,我们参考英、荷、日三国有关企业组织行为的态度量表,设计了一套涵盖企业对市场竞争、文化理念和管理情景的“三模块”总量表,在轻工行业抽取八个样本企业,实施现场实验,采集有关企业组织行为的态度指数,然后与其经济绩效进行关联分析．结果表明,轻工企业组织行为的态度指数与其经济绩效总体趋势呈正相关,但个案分析提示两者间关系复杂,不仅有正相关,也有负相关现象;究其规律尚须扩大样本行纵贯式追踪研究．