视知觉学习的认知与神经机制研究

知觉学习是指由于训练或经验而引起的长期稳定的知觉变化,是一种内隐性的学习。近20年来,视知觉学习的大量研究结果提示大脑皮层的各个区域,甚至包括初级感觉皮层,在成熟之后仍然具有一定的可塑性。该文根据近年来的研究进展,对视知觉学习在大脑的什么地方,什么时候,以何种方式发生等热点问题进行了探讨。研究提示,视知觉学习涉及了包括初级视皮层在内的多个大脑皮层,并且存在一种自上而下的调控机制;视知觉学习可以在不同的时间尺度上发生,快速学习之后将伴随着慢速学习;通过视知觉学习,人们对于复杂物体的表征将从高级皮层区域移向低级皮层区域,任务执行也将趋于自动化     

Super-latent inhibition of conditioned taste preference with a long retention interval

A long delay inserted between conditioning and test phases of a 3-stage Latent Inhibition (LI) procedure produces differential effects on LI depending on the delay context. Thus, enhanced LI has been obtained when the delay is spent in a context that is different from the remaining experimental contexts, but not when it is the same. The present paper examined the effect of delayed testing using a conditioned taste preference procedure. In Experiment 1, three groups received preexposure to either water, or almond, or citrus solutions. Subsequently, the animals were conditioned by pairing the almond and the citrus solutions with sucrose. In a two-bottle preference test conducted 1 day after conditioning, the preexposed flavored solutions were consumed less than the non-preexposed flavors (LI). Experiments 2 and 3 used the same basic procedure, but varied the retention interval duration (1 and 21 days) and the delay context, similar (Experiment 2) and different (Experiment 3) from that of the other stages of the experiments. LI was greater after the long than the short-retention interval when the context was different, thereby demonstrating super-LI. The results were explained by a time-induced context differentiation process.     

围生期双酚A暴露对不同性别子代小鼠行为的影响

探讨围生期母体双酚A(bisphenol A, BPA)暴露对幼年期(生后21~30天, postnatal day 21~30, PND 21~30)和青年期(生后56~63天, PND 56~63)不同性别子代小鼠行为的影响。母鼠从妊娠第7天至断乳前(产后21天)进行BPA(0.05、0.5、5、50 mg/kg/day)灌胃染毒, 同时设对照组。每个剂量组分别在PND 21和PND 56开始测试雌雄子代小鼠各项行为。以旷场行为检测小鼠的自发活动及探究行为, 以高架十字迷宫检测小鼠的焦虑行为, 以水迷宫检测小鼠的空间学习记忆能力, 以跳台检测小鼠的被动回避记忆行为。结果表明, BPA使PND 21雌雄子鼠和PND 56雄性子鼠自发活动减少(p<0.05或p<0.01), 理毛和站立行为发生性别分化(p<0.05或p<0.01); PND 21子鼠的3分钟跑动格数有明显的剂量效应关系, 其中5~50 mg/kg/day组特别显著。BPA显著增加PND 21雌雄子鼠和PND56雌性子鼠在高架十字迷宫中进入开放臂次数和停留时间(p<0.05或p<0.01)并减少封闭臂的进入时间, 但没有明显的剂量效应关系; BPA减少PND 56雄性子鼠开放臂的进入并增加其封闭臂的进入, 干扰了幼年期和青年期小鼠焦虑行为的性别分化。BPA剂量依赖性地延长PND 21和PND 56雄性子鼠在水迷宫搜索平台的平均距离, 其中5~50 mg/kg/day剂量组具有差异显著性(p<0.05或p<0.01), 但对雌性子鼠空间学习记忆行为没有影响。此外, 5~50 mg/kg/day BPA增加PND 21雄性子鼠在跳台实验中的错误次数并缩短其跳下平台潜伏期, PND 56雌雄子鼠的被动回避记忆仅被50 mg/kg/day BPA减弱。以上结果提示, 围生期BPA暴露可影响子代小鼠幼年期和青年期的多种行为及行为的性别差异, 不同行为对BPA的敏感程度不同, 其中以自发活动和探究行为最敏感。     

When Walking Makes Perception Better

ABSTRACT— When we move, the visual world moves toward us. That is, self-motion normally produces visual signals (flow) that tell us about our own motion. But these signals are distorted by our motion: Visual flow actually appears slower while we are moving than it does when we are stationary and our surroundings move past us. Although for many years these kinds of distortions have been interpreted as a suppression of flow to promote the perception of a stable world, current research has shown that these shifts in perceived visual speed may have an important function in measuring our own self-motion. Specifically, by slowing down the apparent rate of visual flow during self-motion, our visual system is able to perceive differences between actual and expected flow more precisely. This is useful in the control of action.     

论中医的辨证论治与肿瘤的分子靶向治疗

辨证论治是中医认识和治疗疾病的基本原则,“同病异治”和“异病同治”是辨证论治的精神实质。恶性肿瘤的分子靶向治疗在很多方面都贯彻了“辨证论治”观念,将所辨的证候落实到受体、基因和各种调控系统上。尽管两者理论基础完全不同,但都强调以患者为中心的综合治疗和个体化治疗理念,对建立正确的临床思维非常重要。     

主观群体动力学模型述评

主观群体动力学模型(subjective group dynamics, SGD)探讨群际背景中个体的群体评价与群体成员评价的关系, 针对群际偏见、分化评估和分化接纳意识(awareness of differential inclusion, ADI)三个核心变量间的关系及其影响因素, 提出并验证了一系列理论假设。SGD的理论基础包括社会认同理论、复杂性–极端性假设和态度极化模型、“白乌鸦效应”和个体对人知觉的发展。SGD模型的研究结果深化了群内偏好研究, 支持了社会领域理论, 并从群体机制角度为同伴拒斥研究提供了新思路, 解释了群体同质性效应并修正了认知发展理论。该领域的发展需要从跨文化检验模型、完善模型结构、研究它与其他变量的关系等方面进行进一步探索。     

Representationalism and indeterminate perceptual content

Representationalists currently cannot explain counter-examples that involve indeterminate perceptual content, but a double content (DC) view is more promising. Four related cases of perceptual imprecision are used to outline the DC view, which also applies to imprecise photographic content. Next, inadequacies in the more standard single content (SC) view are demonstrated. The results are then generalized so as to apply to the content of any kinds of non-conventional representation. The paper continues with evidence that a DC account provides a moderate rather than extreme realist account of perception, and it concludes with an initial analysis of the failure of nomic covariance accounts of information in indeterminacy cases.

智商常态人群的智力个体差异研究述评

智力功能个体差异星正态分布有不同观点：g因素决定特殊能力分化程度差异论、因素搭配差异论;单一认知机能、认知机能系统中的一个或者几个认知机能缺陷影响智力功能差异论;认知发展理论的要素功能大小和要素关联关系强弱、结构差异论;文化活动结构差异和遗传进化的神经效率差异论;神经活动特性水平和神经活动区域效率差异、人格中介情景任务和人     

图片和汉字的激活水平及知觉干扰效应的比较

研究使用8个残缺水平下的图片及其中文名（汉字双字词）为实验材料．试图比较图片与汉字双字词识别激活水平的差异,接着比较二者产生知觉于扰效应的条件,并把二者产生知觉于扰的条件与英文单词产生知觉于扰的条件进行比较。实验一结果发现,在材料较清晰的条件下,汉字双字词的命名成绩高于图片,表明汉字双字词的激活水平不比图片低,但在材料很残缺的条件下,汉字双字词的命名成绩低于图片。实验二发现双字词和图片在没有事先学习情况下都产生知觉干扰效应,已有研究表明单个汉字无需事先学习也可以产生干扰效应,而英文单词需要事先学习。因此,图片和汉字的干扰效应与英文单词的差别跟图片、汉字的激活水平比英文单词高有关。     

亲子间家庭功能的知觉差异及其与青少年孤独感的关系

采用家庭功能评价量表（FAI）,青少年孤独感问卷,对北京和两安的1325名初高中生及其父母进行调查。结果发现：（1）在家庭功能问卷的所有维度,亲子间知觉差异显著,青少年的知觉更消极;（2）在家庭功能的所有维度,男孩与父母的知觉差异均大于女孩与父母的差异;沟通维度父子间的差异大于母予差异,冲突与和谐维度母女间的差异大于父女间的差异;（3）不同知觉差异纽青少年的孤独感差异显著,知觉差异水平与孤独感间呈线性关系;亲子阃在冲突与和谐及父母关注维度的知觉差异可以显著预测青少年的孤独感。