Resilience in Scientific Research: Understanding How Natural Product Research Rebounded in an Adverse Situation

The recent declining rate in the discovery of new drugs has made natural product (NP) research—the traditional method of using living organisms to acquire drug candidates—regain its importance, despite the fact that it was once regarded as an obsolete method in the face of the exalted expectations about emerging new approaches since the 1990s. The concept of ‘resilience’ in scientific research provides a clue for understanding the dynamism of this rebound in research. Four elements may be highlighted in the context of microbial NP research in Japan: first, ‘institutional precondition’ is essential in the sense that the research must be rooted in an institutional complex involving academia, drug companies, and national policies. Second, the dual nature of the ‘attack from rival innovations’ including semiotic labeling and technical advances is examined. Third, four approaches to NP research are observed as responses to such challenges: (1) reevaluating the naturalness of NPs; (2) adopting various technical elements from their rivals; (3) shifting the emphasis from the practical pursuit of drug candidates to biological research using bioprobes; and (4) examining the uneven degree of resilience between academia and industry. Fourth and finally, NPs are viewed as an icon of cultural practice. This view may eventually open the door to questions about the meaning of ‘tradition’ in the context of general contemporary scientific research.     

员工授权期望的效应及其理论机制

以往对领导授权行为的研究大都以领导为中心, 探讨领导授权行为的有效性。随着追随理论的兴起, 越来越多的研究强调从员工视角探讨领导有效性。期望在组织管理中扮演重要角色, 员工授权期望是指员工形成的有关组织中的领导在权力授予方面应尽职责与义务的规范性认知。在系统梳理员工授权期望概念与测量的基础上, 分别从角色设定理论、领导分类理论、期望落差理论梳理了员工授权期望的作用效果与研究结论, 最后从基于内隐领导理论的变量测量、相关理论的机制探讨、追随理论的模型扩展、期望管理的前因探索等方面提出了未来研究的展望。     

Priming of actions increases sense of control over unexpected outcomes

Sense of agency (SoA) refers to the feeling that we are in control of our own actions and, through them, events in the outside world. SoA depends partly on retrospectively matching outcomes to expectations, and partly on prospective processes occurring prior to action, notably action selection.To assess the relative contribution of these processes, we factorially varied subliminal priming of action selection and expectation of action outcomes. Both factors affected SoA, and there was also a significant interaction. Compatible action primes increased SoA more strongly for unexpected than expected outcomes. Outcome expectation had strong effects on SoA following incompatible action priming, but only weak effects following compatible action priming. Prospective and retrospective SoA may have distinct and complementary functions.     

短时距估计中的心理影响因素

使用单任务研究程序,预期式研究范式,以产生时距作为反应指标,通过两个实验考察短时距估计中的间断位置、间断时距和提示线索效应,探讨产生时距与等待时距的关系问题,揭示注意和间断期望对短时距估计的影响。研究结果表明, 间断实验中表现出极其显著的提示线索效应,间断位置（等待时距）效应显著,间断时距效应及间断位置与间断时距的交互效应不显著。由此得出：(1)注意是影响被试时间判断的主要因素,被试的产生时距随着等待时距的增加而延长。(2)被试对间断的期望显著地影响其时间估计行为,无间断实验条件下,间断期望有损于时间估计。     

An Analogue Study of the Psychological and Psychosocial Processes Associated With Post‐concussion Symptoms

This study used an analogue design to investigate post‐concussion syndrome and the psychological and psychosocial processes associated with post‐concussion symptom (PCSx) reporting. The study examined the role of expectation in reporting of PCSx, the nature of associated psychological and psychosocial difficulties, and the “good‐old‐days” phenomenon. Forty‐five healthy participants were randomly assigned to one of two groups: (1) a control group or (2) an expectation group who were asked to perform as if they had experienced a mild traumatic brain injury. Fourteen psychiatric patients comprised the clinical group. Self‐report questionnaires assessing PCSx and psychological and psychosocial variables were administered. It was hypothesised that PCSx would be non‐specific, that the expectation group would report greater dysfunction than controls, and that the “good‐old‐days” phenomenon would cause the expectation and clinical groups to underestimate pre‐morbid PCSx. All participants reported some degree of dysfunction, and the expectation and clinical groups underestimated past PCSx. The expectation group reported more PCSx and psychological and psychosocial dysfunction than controls, resembling the clinical group. The results demonstrate that expectation can cause otherwise healthy individuals to resemble a clinical group in terms of their level of endorsement of psychological and psychosocial dysfunction.     

The role of treatment expectancy in youth receiving exposure-based CBT for obsessive compulsive disorder

The purpose of this investigation was to examine correlates of parent, child, and therapist treatment expectations and their role in the exposure-based treatment of childhood obsessive compulsive disorder (OCD). Treatment expectations were assessed among 49 youth with primary OCD, their parents, and therapists as part of the baseline evaluation and post-treatment clinical outcomes were determined by blind evaluators. Baseline depressive symptoms, child/parent-rated functional impairment, externalizing behavior problems, number of comorbid psychiatric disorders, and a lower perception of control were associated with lower pre-treatment expectations. Parent expectation was associated with parental OCD symptoms, child depressive symptoms and child-reported impairment. Therapist expectations inversely correlated with child depressive symptoms, externalizing problems, and child-rated impairment. Pre-treatment OCD severity and prior treatment history were not linked to expectancy. Finally, higher treatment expectations were linked to better treatment response, lower attrition, better homework compliance, and reduced impairment.     

预期对路径整合的影响

人们通过整合自身运动信息进行的空间巡航称为路径整合。本研究采用头盔式虚拟现实和分段式虚拟迷宫, 探究个体的预期如何影响其路径整合的准确性。任务要求被试从包含4个或8个路段的外出路径的起点出发, 行经所有路段后到达外出路径的终点, 再从终点直接返回起点。三组被试在实验前接受不同的指导语, 并因此对正确返航距离产生不同的预期。实验结果表明, 个体返回起点的行为反应受到外出路径特点的影响, 而且反应的准确性在实际情形违背预期时比符合预期时更低。这样的研究结果表明, 预期作为一种非感知觉因素而影响人们进行路径整合, 体现了人类路径整合的高度适应性和策略性。     

关于动力系统中自我强化和学生期待对学习效率影响的实验研究

本实验考察了在教学活动中,动力系统中自我强化和学生期待两因素与中学生学习效率的关系。结果表明：在其它教学条件相同的情况下,适当地、适时地满足学生期待对初中生学习效率的提高有较明显的作用,而对高中学生则作用不明显;对中学生进行自我强化的训练,有助于高中生学习效率的提高,而对初中生学习效率的作用则不明显;实验中未出现交互作用。     

期望、体验和回忆: 当消费者不能从体验中学习

人们对消费体验的期望、回忆与真实体验时常发生分离, 而且人们很少从真实体验中得到学习。本研究认为原因之一是期望、体验和回忆三者基于不同的输入信息, 以及三者特殊的交互关系。本研究首先提出了一个关于消费者期望、体验和回忆的理论框架, 系统阐述了消费者何时不能从体验中学习以及如何能促进学习, 然后在一个消费情景中通过3×2混合实验设计考察了三者的关系。实验比较了在“预期(无体验)”、“体验后即时评价”和“体验后延迟评价”三种评价方式下被试对两种品牌火腿肠的口味评价和偏好选择。结果发现: 消费者对口味体验的期望和回忆相似, 但两者都和真实体验发生分离。最后, 本研究还讨论了这一理论框架在消费者行为中的应用、未来研究拓展等。     

Investigation of the effect of group counselling based on schema therapy on academic expectation stress in high school students

This research is a preliminary evaluation study to determine whether group counselling based on schema therapy has an effect on academic expectation stress in high school students. In this study, a 2 × 3 split-plot design was used. The Academic Expectation Stress Inventory was applied for data collection purposes. The effect of group counselling based on schema therapy on academic expectation stress was tested using a two-factor ANOVA for mixed measurements. As a result of the analysis, the intervention*time effect was found to be significant with regard to academic expectation stress. The findings obtained in the study reveal that group counselling based on schema therapy creates a significant decrease in adolescents' academic expectation stress level, and this decline continues, as shown in the follow-up test. As a result, it can be said that the group counselling programme based on schema therapy, which was developed as a preliminary evaluation study, has the potential to reduce the academic expectation stress level of high school students.