PTEN、p53和BAG-1在三阴乳腺癌中的表达及意义

为了研究PTEN、p53和BAG-1在三阴乳腺癌中的表达情况及临床病理意义,并讨论三者之间的关系.采用免疫组织化学SP法检测89例三阴乳腺癌中PTEN、p53、BAG-1的表达,其阳性表达率分别为44.9％、47.2％、73.0％,三者的表达均与患者的病理组织学分级、淋巴结转移情况有关(P＜0.05).PTEN的表达与p53、BAG-1表达呈负相关;BAG-1与p53的表达呈正相关,提示三者在三阴乳腺癌中的表达存在一定关联性,临床上联合检测三者可能为TNBC预后评估、患者的个体化治疗提供一定的参考.     

Muslim Governance and the Duty to Protect

In this response to Johnson, Oh reaffirms the scholarly vision of Kelsay and Twiss, elaborates upon Muslim perspectives on human rights, and questions the emphasis on violent humanitarian interventions as part of the Responsibility to Protect mandate. Oh suggests that, in light of the historical relationship between Muslim and non‐Muslim states and the aftermath of the second Iraq War, more consideration be given to the rebuilding of Muslim‐majority societies. Oh also highlights the concept of duty as a religiously based ideal to which governments of Muslim nations ought to be held.     

牟宗三形著说质疑

本文依次从心体是否需要性体保证其客观性,性体能否保证心体的客观性,形著说能否达到预期目的,究竟应该如何看待天道等方面,向牟宗三著名的形著说提出质疑。本文总的结论是,形著说虽有重要的理论意义,但其路子从一开始就没有走对,不仅不能有效解决理论上的难题,而且有叠床架屋之嫌。     

Coping with occupational uncertainty and formal volunteering across the life span

Common wisdom suggests that individuals confronted with occupational uncertainty (e.g., job insecurity and difficulties with career planning) may withdraw from volunteering. We argue that volunteering may be useful to workers in some career stages and that stage-appropriate coping with occupational uncertainty may increase individuals' readiness to volunteer. In Study 1, we used cross-sectional and 1-year follow-up data from Germany that covered three age groups: 16–29 (N_T1 = 1253, N_T2 = 224), 30–43 (N_T1 = 1560, N_T2 = 371), and 56–75 (N_T1 = 518, N_T2 = 215). High engagement and low disengagement in coping with occupational uncertainty were associated with concurrent volunteering in the youngest group but not in the other groups. Over 1 year, high disengagement reduced the likelihood of starting volunteering in the youngest group and increased this likelihood in the oldest group. Study 2 used an independent, cross-sectional German sample that included two age groups: 20–29 (N = 326) and 30–40 (N = 367). Using a different measure of volunteering, Study 2 partly replicated the cross-sectional findings from Study 1. Results suggest that individual agency is a decisive link between occupational uncertainty and the readiness to volunteer, particularly among young labor market entrants.     

Extensions and Mechanisms of Mindfulness‐based Cognitive Therapy: A Review of the Evidence

Mindfulness‐based cognitive therapy (MBCT) was originally developed to prevent depressive relapse and recurrence and has also been widely extended to new patient populations and target problems over the last 14 years. We provide a comprehensive review of this literature, examining the strength of the evidence base for specific populations and target problems and identifying questions for future research to address. Specifically, we review studies addressing the use of MBCT for depressive disorders (prevention of depressive relapse and treatment of residual and current depressive symptoms), the use of MBCT in the treatment or management of other mental disorders (bipolar disorder, anxiety disorders, mixed anxiety and depression symptoms, disordered eating, personality disorders, and psychosis), and the use of MBCT in behavioural medicine contexts. Additionally, we discuss the extension of MBCT during specific developmental periods, like childhood, pregnancy and post‐partum, and adult caregiving, and, finally, we address the use of MBCT among clinical health‐care providers. In the second section, we review hypothesised mechanisms of change in MBCT and reflect on implications for theories of how MBCT works in the application to various patient populations and target problems. We also consider research addressing active ingredients and what is known about the “dosage” of meditation practice. We conclude with a summary of recommendations for future research.     

Effects of an early intervention on maternal post-traumatic stress symptoms and the quality of mother–infant interaction: The case of preterm birth

Preterm birth may represent a traumatic situation for both parents and a stressful situation for the infant, potentially leading to difficulties in mother–infant relationships. This study aimed to investigate the impact of an early intervention on maternal posttraumatic stress symptoms, and on the quality of mother–infant interactions, in a sample of very preterm infants and their mothers. Half of the very preterm infants involved in the study (n = 26) were randomly assigned to a 3-step early intervention program (at 33 and 42 weeks after conception and at 4 months’ corrected age). Both groups of preterm infants (with and without intervention) were compared to a group of full-term infants. The impact of the intervention on maternal posttraumatic stress symptoms was assessed 42 weeks after conception and when the infants were 4 and 12 months of age. The impact of the intervention on the quality of mother–infant interactions was assessed when the infants were 4 months old. Results showed a lowering of mothers’ posttraumatic stress symptoms between 42 weeks and 12 months in the group of preterm infants who received the intervention. Moreover, an enhancement in maternal sensitivity and infant cooperation during interactions was found at 4 months in the group with intervention. In the case of a preterm birth, an early intervention aimed at enhancing the quality of the mother–infant relationship can help to alleviate maternal post-traumatic stress symptoms and may have a positive impact on the quality of mother–infant interactions.     

Listenmee® and Listenmee® smartphone application: Synchronizing walking to rhythmic auditory cues to improve gait in Parkinson’s disease

Evidence supports the use of rhythmic external auditory signals to improve gait in PD patients (Arias & Cudeiro, 2008; Kenyon & Thaut, 2000; McIntosh, Rice & Thaut, 1994; McIntosh et al., 1997; Morris, Iansek, & Matyas, 1994; Thaut, McIntosh, & Rice, 1997; Suteerawattananon, Morris, Etnyre, Jankovic, & Protas , 2004; Willems, Nieuwboer, Chavert, & Desloovere, 2006). However, few prototypes are available for daily use, and to our knowledge, none utilize a smartphone application allowing individualized sounds and cadence. Therefore, we analyzed the effects on gait of Listenmee®, an intelligent glasses system with a portable auditory device, and present its smartphone application, the Listenmee app®, offering over 100 different sounds and an adjustable metronome to individualize the cueing rate as well as its smartwatch with accelerometer to detect magnitude and direction of the proper acceleration, track calorie count, sleep patterns, steps count and daily distances. The present study included patients with idiopathic PD presented gait disturbances including freezing. Auditory rhythmic cues were delivered through Listenmee®. Performance was analyzed in a motion and gait analysis laboratory. The results revealed significant improvements in gait performance over three major dependent variables: walking speed in 38.1%, cadence in 28.1% and stride length in 44.5%. Our findings suggest that auditory cueing through Listenmee® may significantly enhance gait performance. Further studies are needed to elucidate the potential role and maximize the benefits of these portable devices.