Mechanisms underlying corruption of working memory in Parkinson's disease

Working memory (WM) impairments are reported to occur in patients with Parkinson's disease (PD). However, the mechanisms are unclear. Here, we investigate several putative factors that might drive poor performance, by examining the precision of recall, the order in which items are recalled and whether memories are corrupted by random guessing (attentional lapses). We used two separate tasks that examined the quality of WM recall under different loads and retention periods, as well as a traditional digit span test. Firstly, on a simple measure of WM recall, where patients were asked to reproduce the orientation of a centrally presented arrow, overall recall was not significantly impaired. However, there was some evidence for increased guessing (attentional lapses). On a new analogue version of the Corsi-span task, where participants had to reproduce on a touchscreen the exact spatial pattern of presented stimuli in the order and locations in which they appeared, there was a reduction in the precision of spatial WM at higher loads. This deficit was due to misremembering item order. At the highest load, there was reduced recall precision, whereas increased guessing was only observed at intermediate set sizes. Finally, PD patients had impaired backward, but not forward, digit spans. Overall, these results reveal the task- and load-dependent nature of WM deficits in PD. On simple low-load tasks, attentional lapses predominate, whereas at higher loads, in the spatial domain, the corruption of mnemonic information—both order item and precision—emerge as the main driver of impairment.     

眼音距：一个揭示朗读过程中词汇加工的核心指标

朗读是一种出声的阅读方式,而测量朗读过程的一个重要的眼动指标就是眼音距。眼音距是指朗读过程中注视点和发音点之间的时间或空间距离,虽然这个概念早在1920年就提出来了,但直到近十年才受到较多关注,而对于其适用范围及心理学意义,认识尚不充分。本文从眼音距的概念提出和发展入手,分别分析了起始眼音距和结尾眼音距的计算方法和心理学意义,以及它们在快速命名和自然文本朗读任务中对阅读能力和认知控制的反映。未来研究可借助眼音距的特点和优势,进一步探讨朗读过程中副中央凹预视加工的特点和认知控制,以及揭示特殊群体在语言加工缺陷上的发生机制。     

Number and time in acquisition,extinction and recovery

We measured rate of acquisition, trials to extinction, cumulative responses in extinction, and the spontaneous recovery of anticipatory hopper poking in a Pavlovian protocol with mouse subjects. We varied by factors of 4 number of sessions, trials per session, intersession interval, and span of training (number of days over which training extended). We find that different variables affect each measure: Rate of acquisition [1/(trials to acquisition)] is faster when there are fewer trials per session. Terminal rate of responding is faster when there are more total training trials. Trials to extinction and amount of responding during extinction are unaffected by these variables. The number of training trials has no effect on recovery in a 4-trial probe session 21 days after extinction. However, recovery is greater when the span of training is greater, regardless of how many sessions there are within that span. Our results and those of others suggest that the numbers and durations and spacings of longer-duration “episodes” in a conditioning protocol (sessions and the spans in days of training and extinction) are important variables and that different variables affect different aspects of subjects' behavior. We discuss the theoretical and clinical implications of these and related findings and conclusions—for theories of conditioning and for neuroscience.     

Scope Fallacies and the “Decisive Objection” Against Endurance

From time to time, the idea that enduring things can change has been challenged. The latest challenge has come in the form of what David Lewis has called a “decisive objection”, which claims to deduce a contradiction from the idea that enduring things change with respect to their temporary intrinsics, when that idea is combined with eternalism. It is my aim in this paper to explain why I think that no argument has yet appeared that deduces a contradiction from a combination of eternalism and the idea that enduring things change with respect to their temporary intrinsics, except ones that do so by committing scope fallacies.

Excessive Reassurance Seeking, Hassles, and Depressive Symptoms in Children of Affectively Ill Parents: A Multiwave Longitudinal Study

The current study examined whether excessive reassurance seeking serves as a vulnerability factor to depression in a sample of high-risk youth using a multiwave longitudinal design. At Time 1, 140 children (aged 6-14) of affectively disordered parents completed measures assessing reassurance seeking and depressive symptoms. In addition, every 6 weeks during the following year, children and parents completed measures assessing depressive symptoms and the occurrence of hassles. In line with hypotheses, the results of contemporaneous analyses indicated that children with high levels of reassurance seeking reported greater elevations in depressive symptoms following elevations in either hassles or parental depressive symptoms than children with low levels. At the same time, the results of time-lagged analyses indicated that both these relationships were moderated by age with excessive reassurance seeking being associated with greater elevations in depressive symptoms following elevations in either hassles or parental depressive symptoms in older but not younger children.     

Predictors of Attributional Style Change in Children

A number of studies have supported the hypothesis that negative attributional styles may confer vulnerability to the development of depression. The goal of this study was to explore factors that may contribute to the development of negative attributional styles in children. As hypothesized, elevated levels of depressive symptoms and hopelessness at the initial assessment predicted negative changes in children's attributional styles over the 6-month follow-up period. In addition, elevated levels of verbal victimization occurring between the 2 assessments, as well as that occurring in the 6 months preceding the initial assessment, prospectively predicted negative changes in children's attributional styles over the follow-up. Further, initial depressive symptoms and verbal victimization during the follow-up continued to significantly predict attributional style change even when the overlap among the predictors was statistically controlled. Contrary to the hypotheses, however, neither parent-reported levels of overall negative life events nor parents' attributions for their children's events predicted changes in children's attributional styles.     

Individual differences in sentence memory

Results from an experiment with two parts are presented in this paper. In part one, participants listened to sentences containing two, three, four, or five clauses, and were asked questions about the content of the sentences. The results of part one demonstrate that an important unit of representation in sentence memory is the clause, and not some other component of discourse structure. In part two, the same group of participants performed eight different short-term storage/working memory tasks. A composite complex span score was computed for each participant based on three working memory tasks closely based on Daneman & Carpenter's (1980) reading span task. This working memory measure was significantly correlated with the participants' performance on the sentence memory task in part one. A second working memory measure—N-back—was also significantly correlated with the participants' performance on the sentence memory task, and there was no correlation between their performance on the complex span task and the N-back task. It is therefore concluded that (i) working memory consists of a number of dissociable components; and (ii) memory for sentences taps into more than one of these working memory components. Furthermore, the high correlations of sentence memory with the complex span and the N-back tasks (neither of which are language processing tasks) suggests that memory for sentences is not simply a result of linguistic experience; rather, it is likely that an independent working memory component contributes to participants' performance on the sentence memory task.     

比喻性成语对文章段落回忆的影响

本研究采用随意学习的实验范式,探讨了结句中是否包含比喻性成语以及被试的工作记忆容量大小对文章段落回忆成绩的影响.实验中所有被试被要求阅读6个说明体的文章段落,然后接受一个有提示的回忆测验.研究发现(1)所有被试对结句中包含比喻性成语的段落回忆成绩比结句中没有比喻性成语的段落好.(2)结句中是否包含比喻性成语和被试工作记忆容量之间存在着交互作用.若结句中包含比喻性成语,段落的回忆成绩不受被试工作记忆容量的制约,反之则会.这些结果可能表明,比喻性成语的某些特点,如形象性或易记性,作为一种辅助手段促进了被试对文章内容的记忆、保持和回忆.     

Patientenziele in der Psychotherapie

Zusammenfassung  Im vorliegenden Artikel wird ein Überblick zum Stand der Forschung zu Patientenzielen in der Psychotherapie gegeben. Auf vier Aspekte wird dabei besonders eingegangen: (1) auf grundlagenwissenschaftliche Modelle und Befunde zu Lebenszielen, (2) auf allgemeine Lebensziele von Patienten und deren Zusammenhang zu ihrem psychopathologischen Zustand, (3) auf explizite Therapieziele und (4) auf zielbezogene therapeutische Interventionen. Durch diesen Überblick soll zum einen deutlich gemacht werden, wie grundlagenwissenschaftliche Forschung zu persönlichen Zielen klinische Forschung beeinflusst und bereichert hat. Zum anderen werden die therapeutischen Implikationen der Zielforschung herausgearbeitet.

Is T<Emphasis Type="SmallCaps">u</Emphasis> Wei-ming Confucian?

Tu Wei-ming’s discourse has been badly understood by some Western philosophers who study Confucianism. I suggest that this misunderstanding stems from the fact that these philosophers fail to realize that Confucian discourse is in an entirely different register from Western philosophical discourse. I then propose my own preliminary definition of Confucian discourse in five points and present a structural analysis of a text by Tu Wei-ming. Finally, I consider which features of Tu’s discourse can properly be called Confucian. The answer to this question reflects not only on Tu but also on Confucian discourse and the study of Confucianism in general.