Apractic agraphia in a patient with normal praxis

Most right-handed crossed aphasics are not apractic. They usually have agraphia characterized by misspellings but retain the ability to write well-formed graphemes. We describe a right-handed patient with a right parietal lesion who was aphasic and not apractic. He was unable to write any formed graphemes despite a relatively preserved ability to spell aloud. We postulate that praxis and writing are dissociated in this patient because the motor engrams for praxis were located in his left hemisphere and the engrams for writing were in his right hemisphere. In addition, he comprehended commands for limb motor activities (praxis) far better than he comprehended other speech. This suggests that in this patient the areas used to comprehend limb motor commands may be anatomically distinct from areas important in comprehending other aspects of speech.     

The relationship between treatment exposure times and changes in stuttering frequency during contingent stimulation

Four adult stutterers were exposed to 60 consecutive minutes of verbal contigent stimulation. In each session subjects spoke until a stuttering frequency stability criterion was met (baserate) followed by 60 min of exposure to the word wrong presented contingently upon each instance of stuttering. The data were analyzed according to changes in stuttering which occured following 20, 40, and 60 min of treatment exposure. The results revealed that stuttering frequency was reduced for all subjects during all three 20-min segments of the treatment condition. The only significant reductions in stuttering frequency, however, occured within the first 20 min of treatment.     

Social problem solving and mother-child interactions of educable mentally retarded children

Mothers of retarded children and nonretarded children were observed and videotaped as they interacted with their own child in a seminaturalistic situation, requiring teaching, cooperation, and free play. The child's social problem-solving abilities were assessed independently. The Vineland scale was employed to provide some convergent evidence of social problem-solving as a component of social competence. Twelve educable mentally retarded and 19 nonretarded 10-year-old children and their mothers comprised the sample. For the mentally retarded group, it was found that the higher maternal directiveness, the lower the child's social problem-solving skills. Mothers who often gave the child opportunity for decision-making and social influence had children with higher problem-solving skills. The retarded children produced significantly fewer different strategies for solving social problems, but gave a wider range of strategies than has been found in previous research. There was some support that social problem-solving skills are related to social maturity.     

Auditory evoked potentials and sex-related differences in brain development

Auditory evoked potentials (AEPs) were obtained to probe tones which were delivered during the presentation of complex verbal and nonverbal auditory stimulation to 3-month-old infants. Significant sex-dependent AEP amplitude asymmetries were found. Females produced higher-amplitude responses from the left hemisphere and males produced higher-amplitude responses from the right hemisphere during both the verbal and nonverbal presentations. No significant AEP asymmetries were obtained in an independent group of infants that received only the probe tones. These findings are consistent with theories and behavioral data suggesting differences between males and females in the development of language and spatial functions.     

对变化/分割模型的检验(Ⅱ)

在前一报告的基础上设计了两个实验,对变化／分割模型做进一步的检验。实验3控制目标时距和该时距内的填充数字系列的分割段数以及段的持续时间,操纵段内的项目数;结果显示,数字系列的分割段数明显影响延迟操作条件下的时距估计,而段内的项目数则不影响对时距的估计。实验4控制目标时距和该时距内填充数字系列的分割段数以及段内的项目数,操纵段的持续时间;结果显示,对时距的估计取决于被试所使用的时间标尺。四个实验结果表明,变化／分割模型只有较高的预测效度,但也有不足之处。为了更好地从认知的观点解释时距估计的影响因素,作者对已提出的分段综合模型做了进一步的论证,并认为分段综合模型是一个能较完整解释影响人类时距估计的各种因素的理论模型。     

Exploring Behavioral Activation and Inhibition Sensitivities Among College Students at Risk for Bipolar Spectrum Symptomatology

We explored cross-sectionally the roles in bipolar spectrum symptomatology of two broad motivational systems that are thought to control levels of responsiveness to cues of threat and reward, the Behavioral Inhibition System (BIS) and the Behavioral Activation System (BAS). Undergraduate students (n = 357) completed questionnaires regarding (a) bipolar spectrum disorders [the General Behavior Inventory (GBI), a well-established clinical screening measure], (b) current depression and mania symptoms (the Internal State Scale; ISS), and (c) BIS/BAS sensitivities (the BIS/BAS scales). Validated cutoff scores on the GBI were used to identify individuals at risk for a mood disorder. It was hypothesized that, among at-risk respondents, high BAS and low BIS levels would be associated with high current mania ratings, whereas low BAS and high BIS would be associated with high current depression ratings. Multiple regression analyses indicated that, among at-risk individuals (n = 63), BAS accounted for 27% of current mania symptoms but BIS did not contribute. For these individuals, BAS and BIS were both significant and together accounted for 44% of current depressive symptoms.     

The Biological Function Paradigm Applied to the Immunological Self-Non-Self Discrimination: Critique of Tauber's Phenomenological Analysis

Biological self reference idioms in brain-centered or nervous-system-centered self determination of the consious Self reveal an interesting contrast with biological self-determination by immunological self/non-self discrimination. This contrast is both biological and epistemological. In contrast to the consciousness conscious of itself, the immunological self-determination imposes a protective mechanism against self-recognition (Coutinho et al. 1984), which adds to a largely unconscious achievement of the biological Self (Popper 1977; Medawar 1959). The latter viewpoint is in contrast with the immunological Self-determination as an essentially cognitive process as expressed in the analysis of Tauber (1994). Comparison of the immune system in vertebrates and invertebrates, according to new biological insights, has contributed to a better understanding of the relative role of innate (or inherited) immunity versus immunity acquired during each individual life. Also in this respect, immunological self-achievement shows both a striking analogy and a fundamental discrepancy with the activity of the nervous system. The analysis of immunological Self/non-self discrimination versus brain-centered self-determination adds to the understanding of the function paradigm in biological self-reference idioms, especially when regarding the importance of the connectivity notion in both systems. Adopting functional explanatory schemes for understanding immunological self-non-self discrimination, as well as for the understanding of functional mapping of the brain at (conscious) activity (Friston et al. 1993; Frith et al. 1995), forwards the notion of effective/functional connectivity. Network connectivity not only is a primary question in solving the dimensionality question for immunological ‘idiotypic networks’ (Jerne 1974a, b; 1984), it may also have an important value in describing phase transitions in the development of both immune and nervous systems. This revised version was published online in August 2006 with corrections to the Cover Date.     

From Classical Studies towards Epistemology: The Work of József Balogh

In this paper, I introduce a prominent classical scholar, József Balogh, whose work can be read as a significant contribution to the historiography of ancient, and in some sense modern, philosophy. Following a summary biography, I sketch the relevance of Balogh's interpretation of Augustine. I draw some analogies between his and Eric Havelock's treatment of the problems in ancient philosophy, and argue that the obvious similarities between them have a common origin, namely the perspective of the orality/literacy chasm which both treated, in connection with their research into Augustine and Plato, as crucial. Subsequently, I show how the problem of reading aloud, which Balogh was the first to treat systematically, has acquired significance in some current debates in philosophy.