Acceleration model in the heterogeneous case of the general graded response model

A new model, called acceleration model, is proposed in the framework of the heterogenous case of the graded response model, based on processing functions defined for a finite or enumerable number of steps. The model is expected to be useful in cognitive assessment, as well as in more traditional areas of application of latent trait models. Criteria for evaluating models are proposed, and soundness and robustness of the acceleration model are discussed. Graded response models based on individual choice behavior are also discussed, and criticisms on model selection in terms of fitnesses of models to the data are also given.This research was supported by the Office of Naval Research (N00014-90-J-1456).     

A note on distributional properties of the Jöreskog-Sörbom fit indices

In introducing the LISREL model for systems of linear structural equations, Jöreskog and Sörbom proposed two goodness-of-fit indices, GFI and AGFI. Their asymptotic distributions and some statistical properties are discussed.The authors would like to acknowledge the helpful comments and suggestions from the Associate Editor and two anonymous reviewers.     

Matfit: A fortran subroutine for comparing two matrices in a subspace

This research was supported by grant APA 3020 from the Natural Sciences and Engineering Research Council of Canada. The author would like to thank Dr. David O'Hare for providing the data used to illustrate the use of the program MATFIT.     

Some effects of response-correlated increases in reinforcer magnitude on human behavior

After training under short or long fixed-interval schedules, humans responded under a modified fixed-interval schedule in which magnitude of reinforcement (X or 2X) was minimally correlated with response frequency. Response frequencies that equaled or exceeded a minimum response criterion were followed by the larger reinforcer at the end of the interval; otherwise, the smaller reinforcer was delivered. The modified schedule alternated with the baseline schedule across conditions. In a control condition, the reinforcer magnitudes produced by control subjects were yoked to those of experimental subjects. Experimental subjects, but not control subjects, showed increased responding. In addition to the baseline and modified fixed-interval schedules used in Experiment 1, subjects in Experiment 2 also responded under a second modified fixed-interval contingency in which increases in reinforcer magnitude were more highly correlated with response frequency. Experimental subjects, but not control subjects, showed increased responding under both procedures. Direct comparison of these two procedures showed that the high-correlation procedure produced greater increases in responding than did the low-correlation procedure.     

Some properties of two measures of multivariate association

Two kinds of measures of multivariate association, based on Wilks' and the Bartlett-Nanda-Pillai trace criterionV, respectively, are compared in terms of properties of the univariateR ² which they generalize. A unified set of derivations of the properties is provided which are self-contained and not restricted to decompositions in canonical variates. One conclusion is that asymmetric index based on allows generalization of the multiplicative decomposition ofR ² in terms of squared partial correlations, but not the additive decomposition in terms of squared semipartial correlations, while the reverse is true for anasymmetric index based onV.We are indebted to Jos M. F. ten Berge for some fruitful discussions.     

围手术期抗菌药物合理使用与药品费用的相关性分析

通过对本地一所三级甲等医院进行的围手术期抗菌药物的干预对照研究,用SPSS软件对470个手术病例的调查资料进行了统计分析,加强抗菌药物的用药管理及进行用药干预,能在对住院时间和手术切口感染率无影响的同时,明显降低手术病例的药品费用,特别是抗茵药品的费用,减轻患者负担。     

探索性因素分析因子抽取方法的比较

探索性因素分析决定因子抽取的方法主要有Bartlett法、K1原则、碎石检验法、Aaker原则、PA、MAP等六种,通过对样本1的395名大学生的学习过程问卷调查获得真实数据,运用这六种方法进行因素分析分别抽取7、4、2、4、3、2个因子;应用样本2的383名大学生的问卷调查数据进行验证性因素分析,结果显示,碎石检验方法与MAP方法抽取的二因素模型更理想。研究表明,因子抽取需兼顾“简约性原则”与“完备性原则”,同时要根据一定的理论建构、专业知识和经验来决定因子数。     

Plasticity associated with escalated operant ethanol self-administration during acute withdrawal in ethanol-dependent rats requires intact matrix metalloproteinase systems

Repeated cycles of ethanol intoxication and withdrawal associated with dependence induce neuroadaptations in a variety of brain systems. Withdrawal-induced negative emotional states can be ameliorated by ethanol consumption; a learned process termed negative reinforcement. Accordingly, a dependence-induced phenotype is escalated ethanol self-administration. Matrix metalloproteinases (MMPs) are proteolytic enzymes which degrade the extracellular matrix to allow for synaptic reorganization and plasticity. To test the hypothesis that an intact MMP system is required for animals to learn about the negative reinforcing effects of ethanol and display escalated self-administration during acute withdrawal when ethanol-dependent, male Wistar rats were trained to self-administer ethanol and then assigned to either acute or chronic MMP inhibition treatment groups. The chronic treatment group received intracerebroventricular (ICV) infusions of the broad spectrum MMP inhibitor FN-439 or artificial cerebrospinal fluid (aCSF) via osmotic minipumps during a 1 month ethanol dependence induction period and subsequent post-dependence induction self-administration sessions that occurred during acute withdrawal. The acute treatment group only received ICV FN-439 or aCSF on the day of self-administration sessions following dependence induction during acute withdrawal. The results showed that inhibition of MMPs attenuated escalated ethanol self-administration following chronic and acute exposure conditions. Furthermore, once learning (i.e., plasticity) had occurred, MMP inhibition had no impact on escalated response patterns and animals previously subjected to MMP inhibition that did not escalate evidenced normal escalations in operant ethanol self-administration once FN-439 treatments were terminated. Thus, the present data identified that an intact MMP system is required for the escalated responding that occurs during acute withdrawal in dependent animals and implicate such escalation as a learned response.