Resources for resilient caregiving by parents of children with schizophrenia in Swaziland: A multiple case study

This study reports on the care-provisioning experiences of parents (n = 6; females = 5) raising children with schizophrenia in a rural Swazi setting. The parents were individually interviewed at their homes on caregiving aspects such as burden, coping, quality of life, expressed emotions and social support of their child with schizophrenia. Data were thematically analysed. Parent carers of children with schizophrenia reported to have personal resources for resilient caregiving such as motivation for caring, and caregiving satisfaction. They perceived compassion gains from improved quality of life for their children through the caregiving experiences. Findings suggest a need for public mental health education and provision of welfare support of parents’ personal resources for resilient caregiving.     

Assessment of substance abusers on the MCMI-III and the Rorschach

We examined 60 substance abusers (SA) on the Millon Clinical Multiaxial Inventory-III (MCMI-III; Millon, 1994) and on eight Rorschach variables from the Comprehensive System (CS; Exner, 2003). On the MCMI-III, SA scored above the cutoff for clinical significance (M > or = BR 70) on Drug Dependence (94.77), Antisocial (82.95), Depressive (74.33), Self-Defeating (71.48), and Alcohol Dependence (70.70). On seven of the CS variables (M+,o,u, XA%, X-%, WSum6Lv2%, M-%, SumT%, and Pure H%) the scores of the SAs suggested significant more psychopathology compared to the scores of 60 university students, whereas the SA's scores on six of these variables (M+,o,u, XA%, X-%, WSum6Lv2%, SumT%, and Pure H%) suggested significantly less psychopathology compared to the scores of 36 schizophrenics. The effect sizes for the significant differences were in the small, medium and large range (d= 0.31 to d= 1.87).     

Cognitive Behaviour Therapy and Recovery from Acute Psychosis: Case Studies of Two Contrasting Styles

In the North Wales randomised controlled trial of cognitive behaviour therapy (CBT) for acute schizophrenia spectrum disorders, patients who received CBT as an adjunct to treatment-as-usual (TAU) had significantly better outcomes at 12 months than patients who received only TAU. However, patients who were offered CBT but dropped out of treatment early had outcomes that were no worse than patients who stayed in. The explanation for this curious finding might be that the drop-outs and the stay-ins had different but equally valid recovery styles. Two case studies from the trial are presented to illustrate these recovery styles: sealing-over and integrating. Discussion focuses on the idea that, rather than try to alter patients' recovery styles, a more appropriate aim might be to match treatment to the patients' styles.     

精神分裂症神经影像学研究述评

全世界约有1%的人患有精神分裂症,对患者及其家人造成了严重负担。由于此病影响因素很多,精神分裂症研究进展所取得的进步有限。精神分裂症产生的物质基础在脑,神经影像技术的进步为我们直接研究此病活体脑部结构及功能提供了良好的工具。本文主要从四个方面介绍了神经影像学在精神分裂症的研究及所贯彻的哲学思想。     

Childhood trauma and psychosis: Review of the evidence and directions for psychological interventions

There is controversy over whether childhood trauma (CT) is a causal risk factor for psychosis. The aim of this study was to provide psychologists with a brief overview of the research into relationship between childhood trauma and psychosis and directions for psychological interventions. It details six of the highest quality studies in the area and tentatively concludes from these that there is evidence for a relationship between CT and psychosis. Hallucinations and delusions have been implicated as important factors in the relationship between CT and psychotic disorder and these are discussed, along with post‐traumatic intrusions and schemas, which have been conceptualised as part of the psychological mechanisms whereby CT confers a risk for psychosis. The development of psychological interventions for people with psychosis who have experienced CT is in its infancy but has been based on evidence‐based cognitive behavioural interventions in psychosis and post‐traumatic stress disorder. A formulation‐based approach is described in this paper, along with a case study.     

Response inhibition and interference control: Effects of schizophrenia,genetic risk,and schizotypy

The ability to inhibit inappropriate responses and suppress irrelevant information is a core feature of executive control. In this study, we provide a detailed analysis of prepotent response inhibition and interference in patients with schizophrenia. To further test the role of genetic factors and subclinical schizophrenia‐like traits, we additionally studied clinically unaffected, first‐degree relatives of schizophrenia patients and assessed dimensions of schizotypy in both relatives and healthy controls. Inhibition and interference control were assessed using a battery comprising the antisaccade, Stroop, stop signal, go/no‐go, flanker, and Simon tasks. Schizophrenia patients differed from both relatives and controls in making more errors on the antisaccade task and having longer response times on the Stroop task, especially the incongruent condition. Patients also had general, that is, condition independent, increases in reaction times on the go/no‐go and flanker tasks and made more errors on the flanker and Simon tasks, suggesting general performance impairments independent of inhibitory demand. Relatives were characterized by hypometric antisaccade amplitude gain despite normal prosaccades, suggesting a selective deficit in non‐standard sensorimotor transformations. Schizotypy was correlated with inhibitory performance across a number of tasks in both relatives and controls. Generally, these effects were independent of verbal intelligence levels. Overall, the findings point to rather selective impairments of inhibitory control in the schizophrenia spectrum and confirm a previously observed deficit in antisaccade spatial accuracy as an endophenotype of schizophrenia.     

The Paranoid Style in American Politics Revisited: An Ideological Asymmetry in Conspiratorial Thinking

It is often claimed that conspiracy theories are endorsed with the same level of intensity across the left-right ideological spectrum. But do liberals and conservatives in the United States embrace conspiratorial thinking to an equivalent degree? There are important historical, philosophical, and scientific reasons dating back to Richard Hofstadter's book The Paranoid Style in American Politics to doubt this claim. In four large studies of U.S. adults (total N = 5049)—including national samples—we investigated the relationship between political ideology, measured in both symbolic and operational terms, and conspiratorial thinking in general. Results reveal that conservatives in the United States were not only more likely than liberals to endorse specific conspiracy theories, but they were also more likely to espouse conspiratorial worldviews in general (r = .27, 95% CI: .24, .30). Importantly, extreme conservatives were significantly more likely to engage in conspiratorial thinking than extreme liberals (Hedges' g = .77, SE = .07, p < .001). The relationship between ideology and conspiratorial thinking was mediated by a strong distrust of officialdom and paranoid ideation, both of which were higher among conservatives, consistent with Hofstadter's account of the paranoid style in American politics.     

多巴胺D2受体参与调节感觉门控的机制

精神分裂症是一种常见的病因不明的精神疾病。大量文献表明精神分裂症患者所表现出来的认知紊乱和思维异常等症状与感觉门控功能的缺失有密切的关系, 感觉门控是指在充满刺激的环境中, 从外界的感觉信息中过滤无关的感觉信息然后执行与注意力相关的认知过程, 以对显著的刺激做出反应。研究感觉门控的经典范式是震惊反射的前脉冲抑制。研究发现多巴胺D₂受体可以参与调控前脉冲抑制的过程, 但是多巴胺D₂受体参与调控前脉冲抑制的机制仍不清楚。探讨多巴胺D₂受体参与调控感觉门控即前脉冲抑制的关键脑区、神经环路及分子机制, 有利于促进对精神分裂症感觉门控功能的深入研究。     

基于脑结构像的精神分裂症机器学习分类

将机器学习应用于精神疾患的临床和基础研究是近年来的趋势。研究者将机器学习应用于精神分裂症患者及高危人群的T1加权像和弥散张量成像的脑影像数据中, 为了解疾病的生理病理学机制提供帮助。回顾以往研究发现额叶及颞叶的脑结构特征具有较高的区分能力, 行为数据和脑影像数据结合的分类效果优于单模态数据。现阶段研究存在样本量不足和泛化能力欠缺的局限, 未来研究应注意扩大样本量、制定标准化的分类方法, 从而进一步探究机器学习在精神疾患中的作用。