舞动治疗：一种自下而上的精神分裂症干预探索

皮层-基底节-丘脑网络与脑岛网络属于感觉运动相关网络, 这两个网络的改变可能是导致精神分裂症的重要原因。目前主流研究与临床干预聚焦于患者的高级脑区异常, 对感觉运动系统的关注不足。对健康个体的研究发现舞蹈训练对感觉运动相关脑网络具有显著提升作用, 并自下而上地促进高级功能。以上研究提示舞蹈训练可能是干预精神分裂症、改善患者认知功能的新途径。本研究拟借助多模态磁共振成像技术, 以精神分裂症感觉运动相关网络为着力点, 通过分析精神分裂症患者在舞蹈训练前后的脑影像、临床症状及认知行为的改变, 揭示舞蹈训练临床干预的神经机制。     

ONE BRAIN,TWO MINDS: AN ESSAY ON PRIMORDIAL AND ADVANCED MENTAL ACTIVITY

The Primordial Mind in Health and Illness: A Cross‐Cultural Perspective. By Michael Robbins. London/New York: Routledge, 2011. 240 pp.     

Inhibiting reactions to emotional versus non‐emotional response cues in schizophrenia: Insights from a motor‐process paradigm

Recent models of schizophrenia suggest deficient use of contextual response cues when confronted with countermanding emotional cues. It is important to clinically validate these models by testing patients diagnosed with schizophrenia on tasks with competing emotional and contextual response determinants. Control and schizophrenia groups completed a novel task that elicited motor responses consistent with, or in opposition to, pre‐potent emotional actions (i.e., approach vs. avoidance). An analogous non‐emotional task was also used to examine cue‐conflict impairment more generally. The groups demonstrated statistically equivalent performance decrements on incongruent versus congruent trials on both tasks. However, within the schizophrenia group, the incongruency effect was significantly greater in the emotional versus non‐emotional task. These data suggest that, while patients with schizophrenia were able to employ contextual response cues to override competing emotional responses, they were slower to resolve emotional versus non‐emotional response conflict. When patients were subdivided according to the presence or absence of disorganized symptoms, this effect was confined to patients with disorganized symptoms.     

精神分裂症谱系中的快感缺乏

快感缺乏, 指体验愉快能力的降低, 它在精神分裂症病因学中发挥着很重要的作用, 其存在增加了罹患精神分裂症谱系疾病的风险。然而, 精神分裂症中做情绪体验的快感缺乏研究由于方法学的问题常不能得到一致的结果。从奖励系统入手, 最新的研究证据支持精神分裂症期待性愉快损伤, 而消费性愉快相对完好。在分裂型人格中似乎也存在类似的损伤模式。该文从精神分裂症谱系的角度, 探讨了从奖励系统考察快感缺乏的可能。     

自我缺损与精神分裂症

精神分裂症与自我改变的密切关系已经得到了广大研究者的认可。但是, 关于自我在精神分裂症患者中会发生何种变化并对疾病产生何种影响, 目前还没有全面、明确的理解。这篇文章综述了不同学科关于自我的研究, 提出可以从主导感、自我面孔识别、自我参照过程这三个部分来考察精神分裂症的自我缺损, 并回顾了自我这三个成分的相关研究, 分别考察了其对于精神分裂症研究的意义。本综述为全面评估自我缺损与精神分裂症的关系提供了思路。     

Why do High IQ Societies Differ in Intellectual Achievement? The Role of Schizophrenia and Left-Handedness in Per Capita Scientific Publications and Nobel Prizes

Previous research has attempted to understand why countries with relatively favorable conditions and high estimated average IQs (such as Finland and Japan) have a relatively low per capita number of scientific Nobel prizes. In the present study, we examine whether there is a relationship between national schizophrenia and left-handedness prevalence, on the one hand, and per capita scientific and literary achievement, on the other hand, in countries with IQ estimates of at least 90. We found that per capita science and literature Nobel prizes and scientific publications are strongly negatively associated with schizophrenia and strongly positively correlated with left-handedness. There also was a very pronounced negative correlation between schizophrenia rate and left-handedness rate. These results suggest that genius can be regarded as a combination of very high IQ, aspects of high-functioning autism (specifically low empathy) plus relatively low impulse control, consistent with observations of intellectually outstanding individuals, and the fact that schizophrenia appears to constitute the opposite pole of these aspects of autism spectrum. We posit differences in androgen levels as a possible underlying explanation for these findings.     

Effect of schizotypy on responding maintained by free-operant schedules of reinforcement

Deviations from otherwise reliable patterns of responding in human performance on schedules of reinforcement could be associated with personality characteristics, such as psychometrically-measured schizotypy. The present study examined differences between high and low scorers on four schizotypy subscales (unusual experiences, cognitive disorganisation, introvertive anhedonia and impulsive non-conformity) on a random-ratio (RR) and random-interval (RI) schedule of reinforcement. Results showed a higher rate of responding on the RR than RI schedule, consistent with the differences in performance normally observed between these schedules. However, these differences were dependant on whether or not participants scored high or low on the schizotypy subscales, as well as the specific schedule parameters between the schedules. Specifically, high scorers on the unusual experiences (UE) subscale of the O-LIFE(B) were the only group in Experiment 1 not to show a difference in schedule performance, suggesting high scores on this subscale are linked to altered RR and RI performance. Experiment 2 explored this finding further using different schedule parameters, and confirmed that high scorers in UE did not differ in response rates between the two schedules.     

前额叶皮质损伤患者的情绪异常

人类前额叶皮质与情绪之间有着密切的关系,文章在相关的临床和神经成像研究结果基础上,分析了前额叶皮质损伤对情绪行为造成的影响,分别概述了精神分裂症、重性抑郁和焦虑患者的情绪变化、前额叶切除对情绪的影响以及左右前额叶皮质与情绪的关系,重点阐述了前额叶功能异常的神经生理学特点,认为情绪的改变会随着前额叶皮质不同部位的结构缺损或功能变化而有所不同,此有利于对前额叶皮质损伤患者情绪异常的评价与防治。     

精神分裂症治疗的理性思辩

神经解剖、神经生化的研究进展为阐明精神分裂症的病理机制提供了基础,但在精神分裂症的发病中遗传学、环境中的生物学和社会心理因素亦不容忽视.依循系统论的整体性、稳定性观点,采取药物、心理与心理社会康复治疗的综合治疗是目前的最佳方案.     

Culturally Adapted Psychosocial Interventions for Schizophrenia: A Review

Recent research examining the potential efficacy of culturally adapted interventions for various mental disorders illustrates increasing interest in the integration of cultural perspectives into mental health systems. Despite recent evidence demonstrating that culturally adapted interventions may be more effective than a one-size-fits-all approach, few psychosocial treatments for schizophrenia consider cultural factors that may enhance their efficacy with diverse populations. The aim of this review is to discuss the empirical evidence examining the potential utility of culturally adapted group interventions for schizophrenia, as a means to encourage further work and expansion in this area. Specifically, this article provides an in-depth review of the empirical literature on culturally adapted psychosocial interventions for individuals with schizophrenia and their family members, with a focus on group-based interventions. This review is followed by a discussion of a few cultural constructs that may impact patient and family member functioning, and therefore may be important to address in psychosocial treatments for schizophrenia. Finally, we end this review with a broad discussion of research limitations and potential areas for additional research, clinical implications for adapting EBTs to better address cultural concerns, and a case vignette to illustrate how cultural considerations can be integrated into a traditional multifamily group therapy approach.