排序方式: 共有182条查询结果,搜索用时 0 毫秒
111.
探讨MMP-9和TIMP—1在胰腺癌癌细胞及间质的表达与胰腺癌分化程度、分期之间的关系。采用免疫组织化学方法,检测MMP-9和TIMP—1在胰腺癌细胞及间质细胞的表达。MMP-9在胰腺癌细胞和间质组织中均有表达。TIMP—1主要表达在胰腺癌细胞中。MMP-9在胰腺癌间质细胞中的表达高于胰腺癌癌旁组织间质细胞,与胰腺癌的病理分级、分期呈正相关。结论认为MMP-9在胰腺癌间质细胞的表达可能参与胰腺癌的浸润和转移,对预后判断、诊断及治疗具有一定的意义。 相似文献
112.
股骨头坏死(ONFH)是一种进展性和致残性疾病,保存自身股骨头是临床治疗所追求的最理想目标,早中期的治疗方案主要采用非手术疗法和保髋的姑息性手术,目前为止还没有一种治疗方法能达到理想的治疗效果。近年来,骨髓间充质于细胞(MSCs)移植治疗ONFH是目前研究热点之一,有望成为一种有效的治疗方法,晚期行人工髋关节置换术是唯一的和最佳的选择。因此,早期诊断,采用综合性治疗方案保全自身髋关节是治疗本病的主要方向。 相似文献
113.
随着对血管平滑肌细胞增殖在动脉粥样硬化中研究的不断深入,逐步意识到细胞凋亡的存在及其相互之间的矛盾关系,对动脉粥样硬化的认识亦由从形态结构和生化组成等描述病变,发展为在细胞乃至分子基因水平上的深入研究,发现血管平滑肌细胞的增殖和凋亡在动脉粥样硬化形成过程中起重要作用。从哲学角度探讨血管平滑肌细胞在动脉粥样硬化发生中的作用,有助于科学的发现疾病的本质。 相似文献
114.
检测分析早产高胆红素血症(HB)患儿脑干听觉诱发电位测听(BAEP)指标。连续选择近期在我院住院的早产HB患儿176例,入选对象治疗前接受了BAEP检测。胎龄较短、分娩体重较轻、日龄较小和血清高浓度早产儿BAEP检测通过耳数、通过率均明显少于胎龄较长、出生体重较重、日龄较大和胆红素较低浓度旱产儿组(P均〈0.05)。不... 相似文献
115.
以pE1A质粒为模板,扩增E1A基因,然后将E1AcDNA片段插入前期已经构建好的真核表达载体pIRES-Rb94的MCSB的SalI与NotI之间,获得真核双基因表达质粒p1RES-Rb94-E1A,转染肺腺癌A549细胞后,采用RT—PCR和Westernblot方法检测Rb94和E1A在A549细胞中的表达,为研... 相似文献
116.
S. Matthew Liao 《The American journal of bioethics : AJOB》2013,13(6):8-16
Despite the therapeutic potential of human embryonic stem (HES) cells, many people believe that HES cell research should be banned. The reason is that the present method of extracting HES cells involves the destruction of the embryo, which for many is the beginning of a person. This paper examines a number of compromise solutions such as parthenogenesis, the use of defective embryos, genetically creating a “pseudo embryo” that can never form a placenta, and determining embryo death, and argues that none of these proposals are likely to satisfy embryoists, that is, those who regard the embryo as a person. This paper then proposes a method of extracting HES cells, what might be called the Blastocyst Transfer Method, that meets the ethical requirements of embryoists, and it considers some possible concerns regarding this method. It concludes by encouraging future HES cell research to investigate this method. 相似文献
117.
An increasingly unbridgeable gap exists between the supply and demand of transplantable organs. Human embryonic stem cell technology could solve the organ shortage problem by restoring diseased or damaged tissue across a range of common conditions. However, such technology faces several largely ignored immunological challenges in delivering cell lines to large populations. We address some of these challenges and argue in favor of encouraging contribution or intentional creation of embryos from which widely immunocompatible stem cell lines could be derived. Further, we argue that current immunological constraints in tissue transplantation demand the creation of a global stem cell bank, which may hold particular promise for minority populations and other sub-groups currently marginalized from organ procurement and allocation systems. Finally, we conclude by offering a number of practical and ethically oriented recommendations for constructing a human embryonic stem cell bank that we hope will help solve the ongoing organ shortage problem. 相似文献
118.
Michael Morrison 《Science as culture》2019,28(1):46-69
The StemBANCC consortium was a large European consortium bringing together scientists from academic institutions and the pharmaceutical industry. The aim of the consortium was to produce 1500 induced pluripotent stem cell (iPSC) lines from participants with a variety of common, complex diseases. These cell lines were intended to help develop iPSC as tools for screening small molecule drug candidates and modelling human diseases in vitro. The scale of investment in this and other biobanks presents iPSC as a valuable commodity. However, StemBANCC was also mandated to make its making cells and data available to European researchers on a not-for-profit basis. To understand how making this quantity of stem cells and data available is configured as a valuable and worthwhile investment for the consortium partners, research materials (project documents, scientific literature and interviews with scientists working on StemBANCC) were analysed using theoretical tools from Valuation Studies. Combining STS and economic sociology, valuation studies analyse how the worth of things, ideas and phenomena result from context-specific practices of assessment and evaluation; worth incorporates moral, financial, scientific, economic. social and cultural registers of value. In this sense, practitioners evaluate the worth of the StemBANCC cells and data at a variety of sites, from participant recruitment to online databases. This provides an alternative to biovalue and similar conceptual models for theorising the generation of value in the Life Sciences. 相似文献
119.
论胰腺癌手术的术式选择 总被引:2,自引:0,他引:2
胰腺癌是一种高度恶性的腹部肿瘤.胰腺癌切除手术是一种高风险手术,如果病例选择或处理不当会造成严重后果.从哲学的高度更新指导思想和方法,对胰腺癌术式的合理选择以及提高胰腺癌治疗效果大有裨益. 相似文献
120.
胚胎干细胞在治疗学研究中的应用 总被引:1,自引:0,他引:1
AlexanderMcCallSmith MichelRevel 《医学与哲学(人文社会医学版)》2003,24(11):13-17
目前有许多研究人员希望能够从事胚胎干细胞的研究。这项研究可能对可移植组织用于对目前认为难以治疗或不能治疗的许多疾病的治疗的发展带来极大的帮助。然而,由于干细胞是源自人体胚胎。这就提出了如下问题:为了治疗学研究,在胚胎植入子宫之前从人类胚胎上获取细胞以从事实验室培养和研究在伦理上能够被接受吗?不同国家的伦理委员会或国家立法机构关于胚胎研究的观点及其采取的解决办法可能存在显著差异。这种差异在多元性世界里是不可避免的。 相似文献