Post-traumatic stress symptoms in mothers of children with leukaemia undergoing the first 12 months of therapy: Predictive models

The aim of this study consists in the measurement of psychological health and adaptation in mothers of children during the first 12 months of treatment for leukaemia and in the identification of possible early predictors. Ninety-four mothers were followed longitudinally at one week (T1), one month (T2), six months (T3) and 12 months (T4) post-diagnosis. The instruments used were: PTSD symptom checklist, BSI-18, Problem Scale, Ladder of life and an in-depth interview (EFI-C). Couple connectedness, family routine reorganisation, parental communication around the child's illness and trust in the medical care significantly increased from T1 to T4. Two models are proposed concerning possible predictors of mothers’ PTSS at T2 and at T3. Clinical suggestions are proposed on the basis of our empirical findings in order to plan informative, clinical and practical interventions for mothers of children under treatment for leukaemia.     

麻醉诱导期右美托咪定滴鼻在患儿中的镇静及躁动研究

探究麻醉诱导期右美托咪定滴鼻对患儿术中及术后的镇静效果。择期手术患儿60例,随机分为3组,D1组、D2组和C组,麻醉诱导期分别给予1.0μg/kg右美托咪定滴鼻,2.0μg/kg右美托咪定滴鼻和等量生理盐水滴鼻。结果三组滴鼻前时刻T0血流动力学无差异（P〉0.05）,滴鼻后45min时刻（T1）和拔出导管或喉罩时刻（T2）D1组与D2组较C组心率和血压低（P〈0.05）,但在允许范围内;T1、T2时刻,D1组与D2组差异不明显（P〉0.05）;术后躁动评分,D1组与D2组较C组低（P〈0.05）,D2组较D1组低（P〈0.05）;术后疼痛评分,D1组与D2组较C组低（P〈0.05）,D1组与D2组差异无统计学意义（P〉0.05）;术后镇痛需求,D1组与D2组较C组少（P〈0.05）;不良反应无差异（P〉0.05）。麻醉诱导期右美托咪定滴鼻起到有效镇静作用,减少麻醉苏醒期躁动,减轻疼痛。2.0μg/kg的右美托咪定剂量麻醉诱导期滴鼻减少术后躁动效果更明显,不增加不良反应的发生。