PTEN、p53和BAG-1在三阴乳腺癌中的表达及意义

为了研究PTEN、p53和BAG-1在三阴乳腺癌中的表达情况及临床病理意义,并讨论三者之间的关系.采用免疫组织化学SP法检测89例三阴乳腺癌中PTEN、p53、BAG-1的表达,其阳性表达率分别为44.9％、47.2％、73.0％,三者的表达均与患者的病理组织学分级、淋巴结转移情况有关（P＜0.05）.PTEN的表达与p53、BAG-1表达呈负相关;BAG-1与p53的表达呈正相关,提示三者在三阴乳腺癌中的表达存在一定关联性,临床上联合检测三者可能为TNBC预后评估、患者的个体化治疗提供一定的参考.     

标准参照测验决策一致性指标研究的总结与展望

决策一致性指考生在两次平行测验中被一致归类的程度,是衡量标准参照测验质量的重要指标.到目前为止,基于经典测量模型和项目反应模型,研究者已经提出了数十种估计决策一致性指标的方法,并对这些方法的优劣进行了比较.由于模型基础和对分数分布的假设不同,各种方法适用于不同的测验情境.未来的研究应当对已有方法进行验证,并探讨决策一致性在教育测量中的应用途径,为教育和心理测量工作者估计测验的决策一致性指标提供凭据.     

p27和Cyclin E在子宫内膜腺癌中的表达及相关性分析

探讨p27和cyclinE蛋白表达在子宫内膜腺癌的发生、发展中的关系。采用免疫组织化学sP法,测定20例正常子宫内膜、10例不典型增生、40例内膜腺癌中p27、cyclin E蛋白的表达情况。p27蛋白在正常子宫内膜与内膜腺癌的阳性表达比较差异有显著性（P〈0．05）;cyclinE蛋白在正常子宫内膜与不典型增生及子宫内膜腺癌的表达相比较差异均有显著性（P〈0．05）。在子宫内膜腺癌中p27阳性表达率与cyclin E阳性表达率之间存在反向关系。     

The life of p: “Just significant” results are on the rise

Null hypothesis significance testing uses the seemingly arbitrary probability of .05 as a means of objectively determining whether a tested effect is reliable. Within recent psychological articles, research has found an overrepresentation of p values around this cut-off. The present study examined whether this overrepresentation is a product of recent pressure to publish or whether it has existed throughout psychological research. Articles published in 1965 and 2005 from two prominent psychology journals were examined. Like previous research, the frequency of p values at and just below .05 was greater than expected compared to p frequencies in other ranges. While this overrepresentation was found for values published in both 1965 and 2005, it was much greater in 2005. Additionally, p values close to but over .05 were more likely to be rounded down to, or incorrectly reported as, significant in 2005 than in 1965. Modern statistical software and an increased pressure to publish may explain this pattern. The problem may be alleviated by reduced reliance on p values and increased reporting of confidence intervals and effect sizes.     

Effective global management: Established constructs and novel contexts

While there is a growing literature on global managers, most studies in this area have not built upon the wealth of existing knowledge in the field of management development. This study examines if established theoretical constructs will account for managerial performance in complex global jobs and investigates the utility of each of these approaches. Boss performance ratings were correlated with manager's self-ratings on measures of personality, role skill, learning capability, business knowledge, and international experiences for 194 managers--half with global responsibilities and half with domestic responsibilities. Skill in the roles of leader and decision maker were significantly related to performance ratings for managers in high and low global complexity jobs. Learning skills, additional role skills, and international business knowledge were uniquely, albeit modestly, related to performance ratings for managers in globally complex jobs. A development framework is proposed that integrates the various theoretical constructs. Specifically, personality and international experience are considered as antecedent to skill rather than as predictors of global performance. Financial resources are not the problem. We have the money, products, and position to be a dominant global player. What we lack are the human resources. We just don't have enough people with the needed global leadership capabilities.     

Adolescent Decisional Autonomy Regarding Participation in an Emergency Department Youth Violence Interview

Much attention has been given to determining whether an adolescent patient has the capacity to consent to research. This study explores the factors that influence adolescents' decisions to participate in a research study about youth violence and to determine positive or negative feelings elicited by being a research subject. The majority of subjects perceived their decision to participate to be free of coercion, and few felt badly about having participated. However, adolescents who were alone in the room during the assent process were more likely to report that they chose freely to be a research subject. This study may influence the ways physicians communicate with adolescent patients around research assent within a clinical care environment.     

AN EVALUATION OF A PROGRESSIVE HIGH-PROBABILITY INSTRUCTIONAL SEQUENCE COMBINED WITH LOW-PROBABILITY DEMAND FADING IN THE TREATMENT OF FOOD SELECTIVITY

Few studies have examined the effects of the high‐probability instructional sequence in the treatment of food selectivity, and results of these studies have been mixed (e.g., Dawson et al., 2003 ; Patel et al., 2007 ). The present study extended previous research on the high‐probability instructional sequence by combining this procedure with low‐probability demand fading with 2 boys with autism (9 and 10 years old) who had a history of food selectivity and engaged in active food refusal behaviors when presented with novel foods. Response requirements were faded gradually from responses the child would tolerate (e.g., touching the food) to the final requirement of chewing and swallowing the food. The antecedent‐based intervention was implemented in the absence of escape extinction and was effective in increasing food consumption for both participants. Possible mechanisms responsible for the effectiveness of the intervention are discussed along with directions for future research.     

Unintelligibility or Defeat: The Issue of Engagement in Philosophical Debates

A recognition of the acutely terministic and agonistic character of philosophizing has led to the perception of a dilemma in philosophical debates: differing positions are capable of being maintained only at the expense of mutual unintelligibility, and a real contact of minds could never be achieved without one side of the controversy abandoning its position and the enabling argumentative tension ceasing to exist. This perception is sustainable, however, only if we continue to accept the assumption that a direct, unmediated confrontation between disputants personifying two sets of rigidly defined terms is the mode of philosophical argumentation. A triadic rather than diadic conception of a typical debate between opposing schools of thought, which differentiates between the opponent and the audience, would address the theoretical misgivings caused by the perceived predicament.