罗红霉素对兔急性心肌缺血再灌注损伤的作用

研究罗红霉素对兔急性心肌缺血再灌注损伤的作用及机制。新西兰大白兔随机分三组。分别于缺血前、后及再灌注结束后测定MDA、IL-6、IL-8、IL-10、中性粒细胞凋亡率。缺血及再灌注后Apo、IR组较Sham组MDA升高(P0.01);再灌注结束后Apo组较IR组IL-6、IL-8减少,IL-10、中性粒细胞凋亡增加(P0.01)。罗红霉素能保护兔心肌缺血再灌注损伤,与减少致炎因子,诱导中性粒细胞凋亡有关。     

带腓肠神经腓骨复合组织瓣移植修复前臂尺侧缺损

观察以带腓肠神经的腓骨复合组织瓣移植修复前臂尺侧缺损的临床效果。对15例前臂尺侧复合组织缺损的患者实行带腓肠神经的腓骨复合组织瓣移植修复术。结果15例组织瓣全部成活,前臂功能恢复良好。应用带腓肠神经的腓骨复合组织瓣移植修复前臂尺侧缺损,是一种治疗复合组织缺损的有效手术方法。     

Predicting preference for items during periods of extended access based on early response allocation

Top‐ranked items were identified during 30‐min free‐operant preference assessments for 9 individuals. Data from each session were analyzed to identify the item (a) that was engaged with first in each session and (b) to which the most responding was allocated after 5 min, 10 min, 15 min, 20 min, and 25 min had elapsed in each session. The results indicated that the first‐engaged item and the 5‐min high‐allocation item predicted the top‐ranked item in 55% and 62% of the sessions, respectively. The results also showed that engagement with the top‐ranked item from the first session decreased across subsequent sessions for 6 of the 9 participants. The implications of the results for brief versus extended stimulus preference assessments are discussed.     

Procurement time as a determinant of meal frequency and meal duration.

Foraging involves the expenditure of both time and effort in the acquisition of food; animals typically modify their meal patterns so as to reduce these expenditures or costs. The contribution of time, as compared with effort, to the overall cost perceived by an animal is not known. We investigated the effect of foraging time as a cost independent of effort by measuring the meal patterns of rats living in a laboratory foraging simulation in which they earned all their daily intake. They pressed a bar once to initiate an interval (procurement interval) leading to the presentation of a large cup of food from which they could eat a meal of any size. As the length of the interval increased from 1 s to 46 hr, meal frequency decreased regularly. Meal size increased in a compensatory fashion, and total daily intake was conserved through an interval of 23 hr. The changes in meal frequency occurred because of changes in the rat's latency to bar press after each meal. The functions relating meal frequency and size to the procurement interval were of the same shape as those seen when cost is the completion of a bar-press requirement, which entails the expenditure of both effort and time. When the bar-press requirement was increased to 10, meal frequency was reduced, but time and effort did not appear to simply add together in the rat's perception of cost. These data reveal that time is preceived to be a cost by rats foraging in this laboratory environment. These results suggest that the time parameters of foraging are different from those of consumption.     

The implications of rejecting free will: An empirical analysis

While skeptical arguments concerning free will have been a common element of philosophical discourse for thousands of years, one could make the case that such arguments have never been more numerous or forceful than at present. In response to these skeptical attacks, some philosophers and psychologists have expressed concern that the widespread acceptance of such skeptical attitudes could have devastating social consequences. In this paper, I set out to address whether such concerns are well-founded. I argue that there is reason to believe that should skeptical arguments result in the widespread dismissal of human free will, the results of such a dismissal are likely to be more positive than negative.     

Effects of handedness consistency and saccade execution on eyewitness memory in cued- and free-recall procedures*

Identifying characteristics that distinguish between people with relatively good versus poor episodic memory is an important goal of eyewitness-memory research, as is identifying activities that can improve people’s ability to retrieve episodic memories. Consistency of hand preference is a trait associated with the quality of people’s episodic memory and repetitive saccade execution is an activity known to improve people’s ability to retrieve episodic memories. These factors were examined in relation to cued and free recall of a staged criminal event. Individuals with inconsistent hand preference (versus consistent) remembered more on a cued-recall test and also freely recalled a larger amount of victim information. Repetitive saccade execution did not increase cued recall but did increase free recall of victim information. Theoretical implications are discussed, as is potential practical significance, with an emphasis on the size of the observed effects.     

Testing a modified cognitive interview with category clustering recall in Iran

The cognitive interview (CI) has been an effective method for interviewing eyewitnesses often leading to changes in legislation and practice in many countries. This study was the first to employ the CI in Iran and test whether category clustering recall (CCR) was superior to a free recall when incorporated within an investigative interview. A between‐subjects design assigned 66 participants to one of three interview conditions after they watched a mock robbery. The participants were interviewed 48 hr later using either a structured interview (SI), the CI, or a modified cognitive interview (MCI) that replaced free recall with CCR at the first retrieval attempt. Analysis of variance suggests CCR was more effective than free recall and the CI group recalled more information than the SI group, replicating the CI superiority effect. This has implications for law enforcement in Iran and worldwide by suggesting these techniques can be used to enhance recall.     

The weirdness of belief in free will

It has been argued that belief in free will is socially consequential and psychologically universal. In this paper we look at the folk concept of free will and its critical assessment in the context of recent psychological research. Is there a widespread consensus about the conceptual content of free will? We compared English “free will” with its lexical equivalents in Lithuanian, Hindi, Chinese and Mongolian languages and found that unlike Lithuanian, Chinese, Hindi and Mongolian lexical expressions of “free will” do not refer to the same concept free will. What kind people have been studied so far? A review of papers indicate that, overall, 91% of participants in studies on belief in free will were WEIRD. Thus, given that free will has no cross-culturally universal conceptual content and that most of the reviewed studies were based on WEIRD samples, belief in free will is not a psychological universal.     

Spinoza on Lying and Suicide

Spinoza is often taken to claim that suicide is never a rational act, that a ‘free’ person acting by the guidance of reason will never terminate his/her own existence. Spinoza also defends the prima facie counterintuitive claim that the rational person will never act dishonestly. This second claim can, in fact, be justified when Spinoza's moral psychology and account of motivation are properly understood. Moreover, making sense of the free man's exception-less honesty in this way also helps to clarify how Spinoza should, and indeed does, recognize the possibility of rational suicide.