妊娠合并卵巢良性肿瘤的治疗进展

卵巢肿瘤是妊娠期较常见的并发症之一,以良性多见,其并发症发生率高于非妊娠期,孕妇常因并发症引起急腹症就诊,甚至危及母儿的生命,其治疗方式和处理时机与非妊娠期卵巢良性肿瘤明显不同。     

Kidney Transplants From Young Children and the Mentally Retarded

Kidney donation by young children and the mentally retarded has been supported by court decisions, arguments based on obligations inherent in family relationships, an array of contextual factors, and the principle of beneficence. These justifications for taking organs from people who cannot protect themselves are problematic and must be weighed against our obligation to protect the vulnerable. A compromise solution is presented that strongly protects young children and the mentally retarded but does not abdicate all responsibility to relieve suffering. Guidelines are proposed that prohibit the retrieval of kidneys from young children and the mentally retarded but permit one exception. They would allow retrieval of a kidney when the consequence to a first order relative with whom the donor has a meaningful and valuable relationship is otherwise imminent death. This would be done in accordance with additional guidelines that minimize harm to the donor. Since most patients with end stage renal disease can be maintained on dialysis the need for a kidney to prevent death should be an uncommon occurrence. This compromise is proposed as a solution to a dilemma that exists because two ethical principles are in conflict and one cannot be honored without violating the other.     

Current status of psychological research in organ transplantation

Research addressing the psychological concomitants of organ transplantation is reviewed. Specifically, cognitive, behavioral, and psychosocial correlates of kidney, heart, liver, and bone marrow transplantation in both children and adults are discussed. Despite several conceptual and methodological shortcomings of the psychologically-based research in this area, results seem to indicate that organ transplantation is associated with many psychological issues at pretransplantation, posttransplantation, and follow-up periods. Implications of these general findings for the advancing roles of the health psychologist in organ transplantation are discussed.     

关于异种器官移植的问题

随着器官移植的广泛开展,器官短缺的问题日渐突出,８０年代末起异种器官移植的应用引起人们的重视,并形成热潮。但研究表明,克服异种移植排斥非易事,异种器官移植可能引起的病毒性疾病的传播,以及异种器官分子不相容性造成的种属屏障,都使异种器官移植的前景难料。     

移植免疫学的新突破与器官移植

现代器官移植是建立在移植免疫学基础上,移植免疫学基础研究的每一个进展都推动了器官移植的发展。９０年代以来,Ｓｔａｒｚｌ提出了移植排斥的“双向移植排斥理论”,反映了在临床应用免疫抑制药物的情况下,移植排斥的特点,是移植免疫学发展史上的一个重要理论地临床器官移植耐受的诱导具有重要的指导作用。     

从胰腺移植到胰岛干细胞移植

糖尿病学家在胰腺及胰岛细胞移植领域进行了不懈的探索。胰腺移植和胰岛细胞移植的两大制约因素是可供移植的胰腺来源少且诱发受体免疫排斥反应而需应用免疫抑制剂。胰岛细胞制备、纯化技术以及免疫隔离技术的应用在一定程度上克服了上述两大制约因素,人们期待胰岛干细胞技术及其相关的基因技术的深入将这一技术趋于完善。     

活体肝移植供者心理社会方面问题的研究进展

活体肝移植供者心理社会方面问题的主要研究进展为：多数供者与受者之间有血缘关系,或者有亲密的情感联系;供者有利他主义动机;供者术后有短期健康相关生存质量下降,但术后1年之内可恢复正常。     

老龄活体供肾移植的临床应用

为缓解供体器官的严重短缺,老龄活体供肾移植逐渐成为一种可以接受的对策。老龄活体供肾移植有其特殊性并且更易于引发伦理争论。本文简要介绍此问题的研究现状,并就若干社会伦理学问题展开讨论。     

精原干细胞移植治疗男性不育症的伦理学问题

精原干细胞是精子发生的起始,精原干细胞既能分化产生成熟精子又具有自我更新能力以维持自身数量的恒定。精原干细胞移植技术应用于治疗男性不育症,只需将一定数量的供体干细胞植入到受体睾丸的精曲小管内,就能重新建立生精功能。显然,精原干细胞移植在治疗男性不育症有广阔的前景,同时使传统的道德伦理面临着前所未有的困惑。