生物自组织临界性与肿瘤

分析了局部组织由再生、化生和癌变呈现的各种宏观行为和性质,从生物自组织临界性的角度讨论了这类行为和性质的演化模式及机制,指出肿瘤实质是局部组织经历一系列临界状态下相变造成的。     

卵巢肿瘤蒂扭转误诊、漏诊分析

回顾性分析了我院10年间17例卵巢肿瘤蒂扭转病例,并从患者年龄、临床表现、辅助检查、治疗情况等方面对误诊、漏诊的原因进行了分析。发生在青少年、儿童的卵巢肿瘤蒂扭转误诊率为52．9％,发生在绝经后妇女者误诊率为29．4％,最易误诊为急性阑尾炎,临床医生应予以高度重视。     

微流控芯片技术与肿瘤微环境

微流控芯片或芯片实验室或微型全分析系统是在微机械、微电子、生物工程和纳米技术的基础上发展起来的.与传统的实验技术相比,微流控芯片技术以其微型化、集成化、自动化、快速分析、低消耗等优点,不仅在分析化学,物理和化学工程等领域中有出色的应用,近年来在生物工程和再生医学等方面的应用也崭露头角,尤其是微流控技术在肿瘤发生发展的时空微环境研究中发挥出巨大优势.本文就微流控芯片技术在肿瘤微环境中的研究优势进行阐述.     

Impact of negative cognitions about body image on inflammatory status in relation to health

Objective: Evidence suggests that body dissatisfaction may relate to biological processes and that negative cognitions can influence physical health through the complex pathways linking psychological and biological factors.

Design: The present study investigates the relationships between body image satisfaction, inflammation (cytokine levels), aerobic fitness level and obesity in 96 middle-aged men and women (48 normal and 48 overweight). All participants underwent measurements of body satisfaction, body composition, serological measurements of inflammation and aerobic capabilities assessment.

Results: Body image dissatisfaction uniquely predicted inflammation biomarkers, C-reactive protein and tumour necrosis factor-α, even when controlled for obesity indicators. Thus, body image dissatisfaction is strongly linked to inflammation processes and may promote the increase in cytokines, representing a relative metabolic risk, independent of most traditional risk factors, such as gender, body mass index and intra-abdominal (waist to hip ratio) adiposity.

Conclusion: Results highlight the fact that person’s negative cognitions need to be considered in psychologically based interventions and strategies in treatment of obesity, including strategies for health promotion. Results contribute to the knowledge base of the complex pathways in the association between psychological factors and physical illness and some important attempts were made to explain the psychological pathways linking cognitions with inflammation.     

Enhanced counselling for women undergoing BRCA1/2 testing: Impact on knowledge and psychological distress–results from a randomised clinical trial

This randomised controlled trial evaluated the impact of an enhanced counselling (EC) intervention on knowledge about the heritability of breast and ovarian cancer and distress, as a function of BRCA test result, among high-risk women. Before deciding about whether or not to undergo genetic testing, participants were randomly assigned to the EC intervention (N = 69), designed to promote cognitive and affective processing of cancer risk information (following the standard individualised counselling session), or to the control condition (N = 65), which involved standard individualised counselling followed by a general health information session to control for time and attention. Women in the EC group exhibited greater knowledge than women in the control group, 1 week after the intervention. Further, at the affective level, the intervention was found to be the most beneficial for women testing positive: specifically 1 week after test result disclosure, women in the intervention group who tested positive experienced lower levels of distress than women in the control group who tested positive. The findings suggest that the design of counselling aids should include a component that explicitly activates the individual's cognitive–affective processing system.     

Parent Report of Attention Problems Predicts Later Adaptive Functioning in Children with Brain Tumors

Children with brain tumors are at risk for psychological and behavioral difficulties. This study examined the ability of parent report of attention problems, withdrawal, anxiety, and depression, as well as IQ, to predict later adaptive functioning in 42 children treated for brain tumors. Age at diagnosis, SES, gender, and scores on the Neurological Predictor Scale (NPS) also were examined as predictors. Parent report of attention problems, SES, and NPS were significant predictors of later adaptive functioning across domains. This finding highlights the ability of parent report of attention problems to predict later adaptive functioning in children treated for brain tumors.     

肿瘤数据库及组织库的建设

随着肿瘤研究的日益深入,肿瘤组织库的重要性逐渐显现,世界各地都建立了肿瘤组织库。作为肿瘤组织库管理系统和肿瘤临床资料收集、管理者的肿瘤数据库在组织库建设以及肿瘤研究中具有重要的作用。近十年来,我国的肿瘤数据库和组织库开始出现,仍处于起步阶段,存在着诸多问题,建立标准化数据库和组织库具有十分重要的意义。     

肿瘤组织库规范化操作程序的探讨

肿瘤组织是人类直接探讨肿瘤发生、发展和转移机制的研究对象,建立肿瘤组织库(tumor tissue bank,TTB),使用一套规范化操作程序(standard operating procedures,SOPs)来收集高质量的组织标本,避免其浪费势在必行。规范化TTB的建设也将涉及TTB的信息化管理及通用数据元素(common data elements,CDEs)的开发。深入探讨这些方面将有助于我国科研机构建立起自己标准化的TTB。     

应用MDCT检查与诊断大肠癌中的人文关怀

MDCT诊断大肠癌的价值较高。随着医学的发展,医学模式的转变,越来越要求医生在诊断及治疗疾病的同时,从患者心理及社会角度体现人文关怀。完成整个大肠癌的检查及诊断过程需要医生及患者与家属的共同努力,医生在此过程中,不仅要对患者的疾病关注,而且还要体现对患者的心理健康与生命的关怀,社会角色的理解。     

105例额叶、非额叶肿瘤患者词语流畅性作业的比较研究

让４８例额叶肿瘤患者,２６例颞叶肿瘤患者,２６例顶枕叶肿瘤患者,５例额颞肿瘤或颞顶肿瘤患者（全部病人分为左脑肿瘤５６例,右脑肿瘤４９例）说同类词,说非其类词及Ｓｔｒｏｏｐ测验。结果表明：１．额叶组说同类词总和明显低于颞叶组。２．额叶组读色字及读字色两项任务所用时间明显长于颞叶组及顶枕叶组。３．额叶组读色字及字色出现的错误频率明显高于正常人组及顶枕叶组。４．左脑肿瘤组说同类词及读黑色、色字及颜色命名的成绩明显低于右脑肿瘤组。资料提示：额叶肿瘤比颞叶与顶枕叶肿瘤、左脑肿瘤比右脑肿瘤更容易影响被试的词语记忆能力、选择性注意能力及分类归属能力。