阿尔茨海默病的非药物干预与照料

目前阿尔茨海默病尚无根治性的治疗方法,药物治疗基本上是针对临床症状的对症治疗,只能在一定时期内起到改善或延缓疾病发展的作用。非药物治疗包括心理、社会、环境等综合干预,通过多重感官刺激、身体和智能锻炼、芳香治疗、感觉刺激、个性化音乐等方法,配合药物治疗以期尽可能长地保持阿尔茨海默病患者的功能水平,延迟日常生活能力的下降,减轻照料者负担,从而改善阿尔茨海默病患者及其家属的生活质量。对照料者的培训是非药物治疗的重要环节,照料的质量直接影响患者及家属的情绪和生活质量。     

癌痛规范化治疗的制约因素分析

癌痛严重影响中晚期癌症患者生活质量,通过使用第三阶梯强阿片类止痛药物,绝大部分患者疼痛能得到很好的控制。微观上,癌痛治疗的疗效与患者及医务人员的认识程度密切相关,也与医院麻醉科等其他科室的参与程度有关。宏观上,社会人文、经济、政策管理等方面的不足都制约着癌痛规范化治疗的有效实施。癌痛的规范化治疗是一项管理措施,需要进行疼痛评估、家庭支持及宗教组织的参与帮助等。我们国家在文化、经济、教育等各个方面取得长足进步时,癌痛治疗会更加规范、合理、人性化。     

乳腺癌的复发转移病灶需要外科治疗吗？

复发转移是乳腺癌常见的生物学特性。发生复发转移后,疾病常常不可治愈,主要治疗目的是减轻症状,改善生存质量,尽可能延长生存期。复发转移性乳腺癌被认为是一种全身疾病,局部治疗常不受重视,对于复发转移病灶的手术切除是否需要争议较大。但复发转移性乳腺癌也是一种复杂的异质性疾病,对某些亚组的转移病灶进行手术切除,与单纯全身治疗相比,可能进一步改善预后。     

关于抑郁症状的动力学探索及其心理治疗策略

心理因素是导致个体陷入抑郁症状,并难以获得彻底痊愈的根本原因。从心理层面深入探索抑郁发生的病理机制,无疑有利于创新抑郁症状的心理治疗策略,并提升抑郁症状的心理干预效果。本文从动力学的角度,分析了个体的趋利避害机制、压抑机制及效能机制在其抑郁发生过程中的内在动因,初步建构了抑郁发生及其交互作用的模式,并从心理极限的拓展、消极认知的突破和负性精神交互作用的阻断三个方面,努力探索抑郁症状的动力学辅导思路。     

腔内成形术治疗下肢动脉硬化闭塞症的技巧及临床观察

评价腔内成形术（PTA及PTAS）治疗下肢动脉硬化闭塞症的技巧和临床观察。2010年10月至2013年10月,对37例下肢动脉硬化闭塞症血管多段病变患者采用经皮血管腔内成形术和经皮血管腔内成形＋支架植入术治疗。结果36（97％）例手术成功,术后肢体缺血症状完全消失或明显改善,38条患肢皮温明显升高,间歇性跛行消失或距离延长,静息痛好转。术后踝／肱指数（ABI）（0．83±0．12）与术前（0．35±0．07）比较差异有统计学意义（P〈0．05）。合理的腔内成形术（PTA＋PTAS）是治疗下肢动脉硬化闭塞症安全有效的方法。熟练掌握腔内成形术是提高手术成功率和维持通畅率的关键。     

系统生物学引导阿尔茨海默病治疗新策略

阿尔茨海默病（AD）是一种发生于中老年期的退行性脑神经变性疾病,临床上以进行性智能衰退,伴有人格改变为主要特征.其发病过程涉及许多途径和靶点.现代医学认为脑内胆碱能递质功能紊乱、β-淀粉样蛋白沉积、tau-蛋白过磷酸化、炎症反应以及基因突变等在其发病过程中起着重要作用.治疗方法从胆碱酯酶抑制剂、神经递质受体阻滞剂到补气活血、益精填髓、化痰开窍等中医药疗法不等.但抑制剂、阻滞剂等药物阻滞疗法,从单一环节阻断发病途径,忽略了AD发病的整体复杂性.中医辨证论治从整体观念出发,在宏观上治疗AD,对AD的发病缺乏微观深入研究.AD治疗需要借助于“系统生物学”理论的指导.中西医结合为AD的治疗提供了较为科学、有效的途径和发展空间.     

In-Home Parent-Child Interaction Therapy: Clinical Considerations

ABSTRACT

Parent-Child Interaction Therapy (PCIT) is an empirically-supported behavioral parent training program designed to be administered in a clinic or laboratory-based setting. Recently, an empirical investigation revealed that in-home PCIT produced comparable results as the PCIT trials conducted in more controlled environments (this issue). Administering PCIT in a home setting carries both drawbacks and advantages. This article provides an overview of both the positive and negative clinical aspects of conducting in-home PCIT and presents effective solutions to potential treatment barriers.     

An Evaluation of a Self-Protection Skills Program for the Mildly Handicapped

The purpose of the present investigation was to determine the effects of a self-protection curriculum with a group of 10 junior high special education students. The curriculum (Ryerson & Sunden, 1981) was designed to increase the student's ability to identify strangers, recognize unsafe situations, use refusal skill, and understand acceptable and unacceptable touch. The effects of the curriculum were examined using a multiple baseline pre-posttest design across subjects. The results indicated a significant improvement in self-protection skills. Post testing data indicated the self-protection skills ere maintained over time.     

Parents As Teachers:

A follow-up mail survey of the continuing use of behavior modification procedures was conducted with 30 families who had participated in a training program for parents of preschool children with autism four to seven years previously. According to their reports 86% of the parents had used behavioral procedures during the past week to manage their child's behavior and 54% said they used the techniques to teach their child a new skill. More than half of the parties said they no longer used “formal” behavior modification procedures including data collection. Mothers were more likely to use formal behavior modification than father and systematic paternal use of behavioral techniques was linked to maternal use- only one father used the techniques including data collection when his wife did not. Retrospective parental evaluations of the parent training workshop were all positive, although the parents who viewed their children as doing better gave stronger endorsements than the parents who say their children as more limited.     

Short- and Long-Term Effects of Inpatient Cognitive-Behavioral Treatment of Adolescents With Anxious-Depressed School Absenteeism: A Within-Subject Comparison of Changes

The effects of inpatient treatment, including manual-guided cognitive-behavioral treatment (CBT), were examined for 36 adolescents (12–18 years) with chronic school absenteeism and mental health problems. Using a within-subject control group design, no changes were noted during the untreated waiting period, whereas there was a strong, statistically significant reduction in school absence rates and mental health problems from the start to the end of inpatient treatment. At discharge, 88.9% of adolescents attended school regularly or were employed (86.1 and 63.9% at 2- and 9-months follow-up, respectively). Self- and parent-reported mental health problems were significantly reduced during treatment and remained stable during follow-up.