Insights into spared memory capacity in amnestic MCI and Alzheimer's Disease via minimal interference

Impairment on standard tests of delayed recall is often already maximal in the aMCI stage of Alzheimer's Disease. Neuropathological work shows that the neural substrates of memory function continue to deteriorate throughout the progression of the disease, hinting that further changes in memory performance could be tracked by a more sensitive test of delayed recall. Recent work shows that retention in aMCI patients can be raised well above floor when the delay period is devoid of further material - 'Minimal Interference'. This memory enhancement is thought to be the result of improved memory consolidation. Here we used the minimal interference/interference paradigm (word list retention following 10 min of quiet resting vs. picture naming) in a group of 17 AD patients, 25 aMCI patients and 25 controls. We found (1) that retention can be improved significantly by minimal interference in patients with aMCI and patients with mild to moderate AD; (2) that the minimal interference paradigm is sensitive to decline in memory function with disease severity, even when performance on standard tests has reached floor; and (3) that this paradigm can differentiate well (80% sensitivity and 100% specificity) between aMCI patients who progress and do not progress to AD within 2 years. Our findings support the notion that the early memory dysfunction in AD is associated with an increased susceptibility to memory interference and are suggestive of a gradual decline in consolidation capacity with disease progression.     

RACE/A: an architectural account of the interactions between learning, task control, and retrieval dynamics

This article discusses how sequential sampling models can be integrated in a cognitive architecture. The new theory Retrieval by Accumulating Evidence in an Architecture (RACE/A) combines the level of detail typically provided by sequential sampling models with the level of task complexity typically provided by cognitive architectures. We will use RACE/A to model data from two variants of a picture-word interference task in a psychological refractory period design. These models will demonstrate how RACE/A enables interactions between sequential sampling and long-term declarative learning, and between sequential sampling and task control. In a traditional sequential sampling model, the onset of the process within the task is unclear, as is the number of sampling processes. RACE/A provides a theoretical basis for estimating the onset of sequential sampling processes during task execution and allows for easy modeling of multiple sequential sampling processes within a task.     

Age-related differences in working memory: ERPs reveal age-related delays in selection- and inhibition-related processes

Faulty inhibition is implicated in age-related working memory decline. ERP signs of selection and inhibition of items in working memory (WM) are, respectively, a cue-locked parietal positivity (～350 ms) and a probe-locked frontal negativity (～520 ms). To determine when in the older age range differences in selective and inhibitory processes might occur, ERPs were recorded in a WM task from 20 young (20–28), 20 young–old (60–70), and 20 old–old (71–82) adults. A 4-digit display was followed by a cue indicating which 2 of 4 digits were relevant. Proactive interference (PI), the reaction time difference between a matching and non-matching to-be-ignored digit was larger, relative to the young, in both older groups. Compared to the young, both the cue- and probe-locked activities were prolonged in the older groups. Although there were no topographic differences among the age groups, the prolonged PI and associated ERPs suggest a relative age-related deficit in inhibition.     

Proactive control of proactive interference using the method of loci

Proactive interferencebuilds up with exposure to multiple lists of similar items with a resulting reduction in recall. This study examined the effectiveness of using a proactive strategy of the method of loci to reduce proactive interference in a list recall paradigm of categorically similar words. While all participants reported using some form of strategy to recall list words, this study demonstrated that young adults were able to proactively use the method of loci after 25 min of instruction to reduce proactive interference as compared with other personal spontaneous strategies. The implications of this study are that top-down proactive strategies such as the method of loci can significantly reduce proactive interference, and that the use of image and sequence or location are especially useful in this regard.     

Are some video games associated with more life interference and psychopathology than others? Comparing massively multiplayer online role‐playing games with other forms of video game

Massively multiplayer online role‐playing games (MMORPGs) are a type of video game that is considered to have particular potential to be associated with life interference and psychopathology when played frequently and intensively. This study sought to compare players of MMORPGs with players of other types of video game in terms of problematic use, life interference, and levels of psychopathology. An international sample of 1,945 video game players completed a series of questionnaires online. While MMORPG players reported increased rates of problematic use and life interference compared with non‐MMORPG players, there were no differences in levels of psychopathology. Differences between MMORPG players and non‐MMORPG players appeared to be associated with the increased amounts of time that MMORPG players played for: The amount of time spent playing appeared to mediate the relationships between type of game played and each of the problematic use and life interference variables. The implications of these findings are discussed.     

Single-word predictions of upcoming language during comprehension: Evidence from the cumulative semantic interference task

Comprehenders predict upcoming speech and text on the basis of linguistic input. How many predictions do comprehenders make for an upcoming word? If a listener strongly expects to hear the word “sock”, is the word “shirt” partially expected as well, is it actively inhibited, or is it ignored? The present research addressed these questions by measuring the “downstream” effects of prediction on the processing of subsequently presented stimuli using the cumulative semantic interference paradigm. In three experiments, subjects named pictures (sock) that were presented either in isolation or after strongly constraining sentence frames (“After doing his laundry, Mark always seemed to be missing one …”). Naming sock slowed the subsequent naming of the picture shirt – the standard cumulative semantic interference effect. However, although picture naming was much faster after sentence frames, the interference effect was not modulated by the context (bare vs. sentence) in which either picture was presented. According to the only model of cumulative semantic interference that can account for such a pattern of data, this indicates that comprehenders pre-activated and maintained the pre-activation of best sentence completions (sock) but did not maintain the pre-activation of less likely completions (shirt). Thus, comprehenders predicted only the most probable completion for each sentence.     

记忆的知觉干扰效应研究概述

知觉干扰效应是指在识记阶段快速呈现一个单词,紧接着给予一个倒行掩蔽的刺激,在随后的记忆测验中被试表现出对单词的记忆增强的一种现象。知觉干扰效应的影响因素分为测验方式、实验设计方式、实验材料的属性和其他影响因素四个方面。理论解释主要有六种：精细加工假说、时空背景假说、任务要求假说、补偿加工假说、选择性复述假说以及项目特异关联假说。最后,文章从研究领域和实验材料的拓展以及主观因素的影响展望了该研究领域     

注意捕获效应受知觉负载及目标与干扰项距离的共同影响

研究考察了无关干扰项引发的注意捕获效应如何受到任务知觉负载以及目标与干扰项距离的共同影响。被试在视觉搜索集中搜索目标并做辨别反应。通过控制搜索集的大小来控制任务知觉负载, 同时在搜索集中存在一个用颜色标定的无关干扰项(奇异项), 该奇异项与当前的搜索目标存在一致、中性或不一致的关系, 该奇异项的位置与当前目标相邻或相距较远。结果发现, 被试在低负载条件下出现显著的干扰效应(不一致条件的反应时减中性条件的反应时), 而在高负载条件下干扰效应减小。此外, 在高负载条件下, 当目标与干扰项相距较近时没有出现干扰效应, 而当目标与干扰项相距较远时存在显著的干扰效应。干扰效应受到任务知觉负载和目标与无关干扰项距离的共同影响。这些结果说明, 与任务无关的刺激是否捕获注意取决于当前任务总体上是否存在可用的剩余注意资源, 也受到其周围临近区域的局部注意资源是否充足的影响。     

The Effects of Force and Direction Uncertainty on Choice Reaction Time in an Isometric Force Production Task

The two experiments reported examined the temporal organization of force and direction motor-programming processes in a step-input tracking type task. Both experiments observed a reduction in reaction time in the direction-uncertain conditions compared to the direction-certain ones. Thus it seems as though the direction decision does not have to precede the selection of the proper amount of force. Experiment 2 observed an underadditive interaction between levels of direction uncertainty (certain or uncertain) and levels of force uncertainty (certain or uncertain). This interaction was interpreted as support for a parallel organization of the processes responsible for the programming of force and direction and thus, strongly supports the parallel model of programming recently proposed by Klapp (1977a, b).     

Interference Effects in a Numerical Stroop Paradigm in 9- to 12-year-old Children with ADHD-C

Attention deficit hyperactivity disorder (ADHD) is characterized by deficient self-regulation, poor attentional control, and poor response inhibition. To date, however, the extent to which these deficits affect basic interference control remains a matter of controversy. Secondly, ADHD has been reported to be associated with arithmetic deficits. It remains unclear whether such deficits are a secondary consequence of the above-mentioned characteristics of ADHD or whether basic numerical magnitude representations are also affected. In the present study we attempted to investigate these issues using a basic numerical interference paradigm.

Nine- to twelve-year-old children with ADHD-C (attention-deficit hyperactivity-disorder combined type) and control children without ADHD (each n = 16) were presented with two digits of possibly different physical sizes (e.g., 3 7). This numerical Stroop task requires subjects to make a magnitude classification concerning either the physical or the numerical stimulus dimension. The irrelevant dimension can be congruent (same response), incongruent (different response), or neutral (no response association).

Children with ADHD-C performed worse than control children in most analyses. The most important finding was a significant interaction of congruity effects with group in the numerical comparison task. Children with ADHD-C tended to show larger congruity and interference effects than controls, and these were not attributable to a speed-accuracy trade-off.

The results might reflect differential processing speeds, or a different degree of automatic activation of physical and numerical magnitudes in children with and without ADHD-C. Alternative explanations, such as insufficient inhibition of selective (domain-specific) attention are also discussed.