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141.
142.
Dominguez FJ Lawrence C Halpern EF Drohan B Grinstein G Black DM Smith BL Gadd MA Specht M Kopans DB Moore RH Hughes SS Roche CA Hughes KS 《Journal of genetic counseling》2007,16(3):341-345
The self-reporting of cancer history is becoming increasingly important, as it frequently guides medical decision-making.
We studied the accuracy of personal cancer history using a self-administered questionnaire, comparing the results with the
Tumor Registry at our institution. Among 39,662 records, we identified 3614 women with a single cancer in the Tumor Registry
who reported none or one cancer on their questionnaire. The sensitivity in self-reporting cancers was 85.7%, ranging from
92.1% for breast cancer to 42.9% for leukemia. The accuracy for breast cancer and Hodgkin's Lymphoma was significantly better
than other cancers (p=0.00027, CI: 1.4–3.88). Analysis of patient's characteristics showed that Caucasians reported breast cancer more accurately
than Asian/Pacific Islanders (p=0.008), and those with Jewish ancestry more accurately than non-Jewish (p=0.0435). These results will help us to improve data collection and thus improve medical decision-making. 相似文献
143.
A method is presented for marginal maximum likelihood estimation of the nonlinear random coefficient model when the response
function has some linear parameters. This is done by writing the marginal distribution of the repeated measures as a conditional
distribution of the response given the nonlinear random effects. The resulting distribution then requires an integral equation
that is of dimension equal to the number of nonlinear terms. For nonlinear functions that have linear coefficients, the improvement
in computational speed and accuracy using the new algorithm can be dramatic. An illustration of the method with repeated measures
data from a learning experiment is presented. 相似文献
144.
Resource-limited regions of the world represent the areas most affected by the global HIV epidemic. Currently, there are insufficient
data on the neurocognitive effects of HIV in these areas and neuropsychological studies that have been carried out thus far
are marked by inconsistent methods, test batteries, and rating systems for levels of cognitive impairment. These differences
in methods, along with genetic variability of both virus and host, differences in co-infections and other co-morbidities,
differences in language and culture, and infrastructural deficiencies in many international settings create challenges to
the assessment of neurocognitive functioning and interpretation of neuropsychological data. Identifying neurocognitive impairment
directly attributable to HIV, exploring relationships between HIV-associated neurocognitive impairment, disease variables,
and everyday functioning, evaluating differences in HIV-1 subtype associated neuropathology, and determining implications
for treatment remain complicated and challenging goals. Endeavors to establish a more standardized approach to neurocognitive
assessments across international studies in addition to accumulating appropriate normative data that will allow more accurate
rating of neuropsychological test performance will be crucial to future efforts attempting to achieve these goals. 相似文献
145.
Gerhard Minnameier 《Journal of Adult Development》2009,16(3):131-143
The study provides an in-depth analysis of two young adult subjects from a longitudinal study who underwent successive and
significant developmental changes. Their developmental patterns, however, are only revealed by a new conception of moral stages,
which is both more comprehensive and more detailed than Kohlberg’s original approach. In particular, the suggested alternative
taxonomy neatly accommodates what appears as developmental anomalies in the Kohlbergian frame of reference. What is more,
apart from merely matching with the observed data, the new theory also explains why the subjects developed the way they did,
since it reveals the inherent cognitive conflicts at each stage and how these are resolved at the following one. Although
the theory stands against the Kohlberg theory as it is, it may be understood as an extension and further development of the
latter, in the sense that Kohlbergian stages are differentiated, supplemented, and theoretically substantiated within the
new framework.
相似文献
Gerhard MinnameierEmail: |
146.
147.
Francesco Bartolucci 《Psychometrika》2007,72(2):141-157
We illustrate a class of multidimensional item response theory models in which the items are allowed to have different discriminating
power and the latent traits are represented through a vector having a discrete distribution. We also show how the hypothesis
of unidimensionality may be tested against a specific bidimensional alternative by using a likelihood ratio statistic between
two nested models in this class. For this aim, we also derive an asymptotically equivalent Wald test statistic which is faster
to compute. Moreover, we propose a hierarchical clustering algorithm which can be used, when the dimensionality of the latent
structure is completely unknown, for dividing items into groups referred to different latent traits. The approach is illustrated
through a simulation study and an application to a dataset collected within the National Assessment of Educational Progress,
1996.
The author would like to thank the Editor, an Associate Editor and three anonymous referees for stimulating comments. I also
thank L. Scaccia, F. Pennoni and M. Lupparelli for having done part of the simulations. 相似文献
148.
The accurate interpretation of large numbers of neuropsychological tests within a flexible battery approach is a difficult and sometimes controversial process. We present a statistically based method of interpretation (Rohling's Interpretive Method or RIM) and evaluation of neuropsychological data that allows for varying numbers of tests along a varying number of cognitive domains, yet remains psychometrically based. This method requires informed clinical judgment in that the level of confidence for tests, cognitive domains, and global indices are used as the backdrop for interpretive decisions. Specific procedures for use are presented in a systematic, detailed fashion to allow the interested reader to replicate the method. Two case examples are presented: a straightforward case of cerebrovascular insult and a more complicated case of mixed etiology. Examples include a variety of different neuropsychological tests commonly used in a flexible battery approach. A discussion of the practicality, ease of use, and potential limitations of this method are further presented. 相似文献
149.
Although experimental effects typically are evaluated by summarizing levels of responding across time (e.g., calculating the mean levels of problem behavior during 10‐min sessions), these data summaries may obscure important mechanisms that may be responsible for changes in responding. A case study is reported to illustrate alternative methods of data analysis when decreasing trends in responding may be due to increases in response efficiency. 相似文献
150.