药物不良反应社会成本控制最优化的经济学分析

药物不良反应(adverse drug reaction,ADR)是导致患者住院的常见原因并造成高额的社会成本。由于避免ADR的边际成本是递增的,因此从经济学的角度来看,ADR的发生率不是最小化而是最优化问题,是在成本与效益之间找到最优平衡的问题,本文对ADR发生率的最优平衡点和相关的制度作了探讨。     

Multicriteria Optimization Technique for Optimal Design of Orthotropic Bridges

The design improvement of large‐scale structures such as cable stayed and suspension bridges with large spans is one of the major engineering optimization problems faced by design engineers. In many real‐life engineering design problems, it is necessary to carry out large‐scale experimental physical models for only one prototype to construct the feasible solution set that is too expensive and not practical. For these reasons, an experimental search for optimal solutions is often not carried out at all. This paper presents a technique for multicriteria analysis, which involve the finite element analysis of the prototype in the optimization process. The improvement of the Suez Canal Bridge in Egypt is introduced as a real‐life large‐scale case study. The parameter space investigation method, the visual basic for application programming language, and Femap as finite element analysis software provide an implementation tools to construct the feasible and Pareto solution sets for the studied bridge. An efficient combination between the parameter space investigation method and the finite element programme was successfully investigated to obtain the Pareto solution set. This study shows possibility to apply the multicriteria optimization method for more applications on different large‐scale structural systems in the future. Copyright © 2013 John Wiley & Sons, Ltd.     

一种基于进化算法的概化理论最佳样本量估计新方法：兼与三种传统方法比较

概化理论在心理与教育测量领域应用较广。如何使测量程序在预算限制的情况下达到较优的可靠性是研究者需要考虑的重要问题, 这个问题可以转换为最佳样本量估计的问题。提出了一种基于进化算法的估计概化理论下最佳样本量的新方法——约束进化算法, 并采用模拟研究的方法比较了微分优化法、拉格朗日法、柯西不等式法等三种传统方法与约束进化算法的优劣。结果表明：在两侧面交叉设计、两侧面嵌套设计和三侧面交叉设计中都证明了约束进化算法更具优越性, 建议研究者在今后的研究中优先使用。     

Adaptive criterion setting in perceptual decision making

Pigeons responded in a perceptual categorization task with six different stimuli (shades of gray), three of which were to be classified as "light" or "dark", respectively. Reinforcement probability for correct responses was varied from 0.2 to 0.6 across blocks of sessions and was unequal for correct light and dark responses. Introduction of a new reinforcement contingency resulted in a biphasic process of adjustment: First, choices were strongly biased towards the favored alternative, which was followed by a shift of preference back towards unbiased choice allocation. The data are well described by a signal detection model in which adjustment to a change in reinforcement contingency is modeled as the change of a criterion along a decision axis with fixed stimulus distributions. Moreover, the model shows that pigeons, after an initial overadjustment, distribute their responses almost optimally, although the overall benefit from doing so is extremely small. The strong and swift effect of minute changes in overall reinforcement probability precludes a choice strategy directly maximizing expected value, contrary to the assumption of signal detection theory. Instead, the rapid adjustments observed can be explained by a model in which reinforcement probabilities for each action, contingent on perceived stimulus intensity, determine choice allocation.     

The pursuit of optimal distinctiveness and consumer preferences

He, L., Cong, F., Liu, Y. & Zhou, X. (2010). The pursuit of optimal distinctiveness and consumer preferences. Scandinavian Journal of Psychology, 51, 411–417. This article investigates the effect of optimal distinctiveness on consumer product consumption. The authors argue that consumers acquire and display material possessions to restore their optimal levels of distinctiveness. Results showed that placing consumers in a state of low distinctiveness increased desire to acquire distinctive products, whereas perceptions of high distinctiveness reduced desire to acquire such products. Consumers’ desire for distinctiveness‐related products held true for various consumer choices, including willingness to pay more for limited‐edition products and preference for unpopular gifts. This finding has implications for understanding consumer choice in expressing identity.     

内隐序列学习的表征机制及年龄效应研究

该研究从年龄效应这一独特视角探讨了内隐序列学习的表征机制。结果表明:(1)内隐序列学习存在具体联结和抽象层级编码双重表征机制,且在该研究中以抽象编码为主;(2)老、青、幼三组被试的内隐序列学习无显著差异,间接支持了具体联结机制不起主要作用的结论。该研究的推论是:(1)内隐序列学习的表征是一个遵循“最优级编码”的动态过程;(2)该过程不涉及注意机制和短时记忆。     

高血压治疗：百年历程、日益细化

人类对高血压的治疗是百年以来医学的重要成就。越来越多的证据表明,有效控制高血压是降低相关疾病发病、死亡、致残的重要手段。医学对高血压治疗药物、手段、方案的探索尚未止步,许多正在进展中。     

Experimental studies of sequential selection and assignment with relative ranks

We study a class of sequential selection and assignment problems in which a decision maker (DM) must sequentially assign applicants to positions with the objective of minimizing expected cost. In modeling this class of problems, we assume that on each period the DM is only informed of the rank of the present applicant relative to the applicants that she previously observed and assigned. We first present the optimal decision policy that we subsequently use as a normative benchmark, and then report results from three experiments designed to study sequential assignment behavior. In comparing the aggregate results from all three experiments to the optimal decision policy, we identify a systematic bias, called the middleness bias, to over‐assign applicants to intermediate positions. The results also reveal a strong bias for early applicants to be over‐assigned to important positions. Copyright © 2006 John Wiley & Sons, Ltd.