药物性肝损伤的发病机制

药物性肝损伤（DILI）可分为直接肝毒性和特异质性肝损伤（IDILI）.IDILI发生率较低,个体发病存在易感因素,在动物模型中很难复制.同时,IDILI缺乏可靠的临床诊断标准,使其发病机制的研究受到限制.近年来关于IDILI的发病机制,主要在遗传易感性、代谢途径、宿主免疫、线粒体毒性和胆道损伤等方面取得进展,各种发病机制的深入研究和相互关系的阐明,或将揭示IDILI的真正致病机制.     

Size effects and Hall–Petch relation in polycrystalline cobalt

The mechanical behaviour of polycrystalline hexagonal close-packed cobalt was investigated over a large range of grain size d in order to examine the occurrence of size effects. Crystallographic texture and amount of face centred cubic allotropic phase were maintained unchanged thanks to appropriate heat treatment procedures. The Hall–Petch (HP) relation exhibits two distinct behaviours from the very beginning of plastic strain levels. The conventional HP law is fulfilled for a number of grains across the thickness t higher than a critical value (t/d)_c = 14. For t/d lower than (t/d)_c, a multicrystalline regime is evidenced highlighting a strong reduction in flow stress. The high value of (t/d)_c is related to the low-stacking fault energy of cobalt in the basal plane. The size effect is predominant in the first work hardening stage where slip mechanisms and stacking faults predominate. In the second stage, driven by mechanical twinning processes, this effect is less sensitive. Finally, the size effect could also affect the end of the elastic stage, in link with nonlinear elasticity mechanisms.     

第二类有中介的调节模型

心理学研究常用有中介的调节模型揭示调节作用通过中介变量间接实现的现象。介绍了第二类有中介的调节模型(meMO-II)的概念及优势; 将meMO-II与其它中介调节混合模型进行了辨析; 给出了meMO-II的建模方法和分析流程, 并用一个实例演示; 介绍了基于潜变量的meMO-II的分析方法、meMO-II建模方法的新进展以及meMO-II的变式。研究有助于推动调节机制研究的发展。     

人们为什么会羞怯：认知机制及神经基础

羞怯指个体在社交情境下的抑制, 是个体参与社交的阻碍。近年来, 关于羞怯的认知神经科学研究增多, 学者基于元认知模型、社会适应模型、侧化脑-体情绪模型等理论, 探讨了大脑结构和功能以及几种与感知觉和注意相关的ERP成分与羞怯的关系。但当前关于羞怯认知神经科学的理论和实证研究尚处于起步阶段。基于上述提出羞怯的心理发展模型; 未来应从人格和情绪双角度研究羞怯, 并在开发研究范式的基础上, 加大羞怯认知神经机制的探讨。     

Psychological maturity and change in adult defense mechanisms

Change in the use of defense mechanisms between late adolescence and adulthood was assessed in two different longitudinal studies from the Institute of Human Development. The results were virtually identical: the use of Identification decreased, the use of Denial increased, and there was little change in the use of Projection. Both the use of Identification at adolescence, and its subsequent decrease in adulthood were found to be predicted by ego strength and committed Identity - that is, by evidence of developmental maturity at late adolescence. The decrease in Identification is consistent with predictions from the theory of defense mechanism development: defenses are related to developmental period; once that period is concluded, the use of the related defense declines.     

Exclusion constraints facilitate statistical word learning

The roles of linguistic, cognitive, and social-pragmatic processes in word learning are well established. If statistical mechanisms also contribute to word learning, they must interact with these processes; however, there exists little evidence for such mechanistic synergy. Adults use co-occurrence statistics to encode speech-object pairings with detailed sensitivity in stochastic learning environments (Vouloumanos, 2008). Here, we replicate this statistical work with nonspeech sounds and compare the results with the previous speech studies to examine whether exclusion constraints contribute equally to the statistical learning of speech-object and nonspeech-object associations. In environments in which performance could benefit from exclusion, we find a learning advantage for speech over nonspeech, revealing an interaction between statistical and exclusion processes in associative word learning.     

发展性阅读障碍与小脑异常：小脑的功能和两者的因果关系

发展性阅读障碍(下文简称为"阅读障碍")不仅会影响个人的终身发展,还会对社会造成沉重的经济负担,深入探讨相关的神经机制,对实现阅读障碍的早期预测和干预十分重要。以往关于阅读障碍神经机制的模型多集中于大脑,近些年的研究发现,阅读障碍也与小脑异常有关,但到目前为止我们仍不清楚两者的关系。通过总结最新的研究进展,我们发现小脑在阅读障碍中可能发挥着多种功能,且小脑异常与阅读障碍可能互为因果。在此基础之上,我们提出了"阅读中小脑与大脑的功能映射假说",旨在从一个全新的角度揭示小脑与阅读的关系,以及两者与大脑的关系。相关内容对全面揭示阅读障碍的神经机制,以及小脑在高级认知加工中的作用,具有重要的启示意义。     

The dynamics,processes, mechanisms,and functioning of personality: An overview of the field

Personality psychology has long focused on structural trait models, but it can also offer a rich understanding of the dynamics, processes, mechanisms, and functioning of individual differences or entire persons. The field of personality dynamics, which works towards such an understanding, has experienced a renaissance in the last two decades. This review article seeks to act as a primer of that field. It covers its historical roots, summarizes current research strands – along with their theoretical backbones and methodologies – in an accessible way, and sketches some considerations for the future. In doing so, we introduce relevant concepts, give an overview of different topics and phenomena subsumed under the broad umbrella term ‘dynamics’, and highlight the interdisciplinarity as well as applied relevance of the field. We hope this article can serve as a useful overview for scholars within and outside of personality psychology who are interested in the dynamic nature of human behaviour and experience.