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71.
    
The advent of antimicrobial resistance has added considerable impact to infectious diseases both in the number of infections and healthcare costs. Furthermore, the relentless emergence of multidrug-resistant bacteria, particularly in the biofilm state, has made mandatory the discovery of new alternative antimicrobial therapies that are capable to eradicate resistant bacteria and impair the development of new forms of resistance. Amongst the therapeutic strategies for treating biofilms, antimicrobial photodynamic therapy (aPDT) has shown great potential in inactivating several clinically relevant micro-organisms, including antibiotic-resistant ‘priority bacteria’ declared by the WHO as critical pathogens. Its antimicrobial effect is centred on the basis that harmless low-intensity light stimulates a non-toxic dye named photosensitizer, triggering the production of reactive oxygen species upon photostimulation. In addition, combination therapies of aPDT with other antimicrobial agents (e.g. antibiotics) have also drawn considerable attention, as it is a multi-target strategy. Therefore, the present review highlights the recent advances of aPDT against biofilms, also covering progress on combination therapy.  相似文献   
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The present study examined the mediating effects of negative affect at work between abusive supervision and dysfunctional resistance, considering aggressive humor as a moderator. Two hundred and thirty-five full time working employees participated in the study. Correlational results indicated that aggressive humor was related to dysfunctional resistance. However aggressive humor was not related to negative affect at work. Aggressive humor moderated the direct path (i.e., between abusive supervision and dysfunctional resistance), but it did not moderate the indirect paths. Finally, the study found support for negative reciprocity beliefs (Gouldner, 1960). Implications for practice include an emphasis on self-awareness training for managers.  相似文献   
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A new instrument, the Psychological Maltreatment Review (PMR), is introduced and its psychometrics are described. The PMR examines adult retrospective reports of child psychological abuse, psychological neglect, and psychological support, measured separately for maternal and paternal figures. Male and female participants (N?=?1,051) completed the PMR and a measure of adult attachment, the Revised Experiences in Close Relationships scale (Fraley, Waller, &; Brennan, 2000). The three scales of the PMR demonstrated very good internal consistency. The structural validity of the PMR was supported by both exploratory and confirmatory factor analyses, as was the notion of an independent parental support/nonsupport variable. Indicative of the construct validity of this measure, all PMR scales were significantly correlated with anxious and avoidant attachment in close relationships. Hierarchical multiple regression analyses indicated that paternal neglect and maternal psychological abuse predicted participants' anxious attachment, whereas less paternal and maternal support was associated with avoidant attachment.  相似文献   
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By tracing a portion of close process of a patient's shifts from a relatively silent and inhibited stance to one in which he is beginning to verbalize more about his experience and fantasy, I will illustrate some tensions between the analyst's role as facilitating expressiveness and as occupying a place in the patient's internalized world. Since the analyst's functions as facilitator and as internal object (often an obstacle to the patient's expressiveness) are sometimes in conflict with one another, it is important for the analyst to be able to work internally with this conflict as he works with his patient. Splitting processes between these two functions may provide the analyst with cues related to the patient's and the analyst's resistance to understanding the patient's communication of unconscious conflict and the patient's recruitment of the analyst into the patient's internalized world.  相似文献   
77.
Mg–Sn-based alloys are considered as a promising precipitation-hardening system for applications at elevated temperatures, but the hardening effect is not satisfactory owing to sluggish nucleation and rapid coarsening of the major Mg2Sn lath precipitates. In this study, Cu and Al are added to a Mg–6Sn–1Mn base alloy. The age-hardening response and the microstructures of these modified alloys have been investigated and are compared to that of the base alloy. The additional elements are found to bring several beneficial effects to the alloys for applications at elevated temperatures. Firstly, a eutectic structure consisting of strong intermetallic phases, i.e. Mg2Cu in the Mg–6Sn–1Mn–2Cu alloy and Al0.93Cu1.07Mg in the Mg–6Sn–1Mn–2Cu–2Al alloy, remains stable along the grain boundaries after solution and ageing heat treatments. Secondly, the precipitate density has been increased significantly and the precipitate size has been refined remarkably during ageing at 200?°C. Moreover, the growth of the precipitates is inhibited remarkably during the over-ageing period. Therefore, the age-hardening response and over-ageing resistance are notably improved.  相似文献   
78.
Researchers have proposed that high quality of supervisor–employee relationships (Basu & Green, 1997; Scott & Bruce, 1994; Sanders, Moorkamp, Torka, Groeneveld & Groeneveld, 2010) fosters innovative behaviour. Moreover, researchers have acknowledged that this relationship is not clear (Rosing, Frese & Bausch, 2011; Volmer, Spurk & Niessen, 2012). The present study aims at testing the moderating role of resistance to change in the LMX-innovative behaviour relationship. Results of a study based on 160 participants from an organization provide empirical support to this hypothesis.  相似文献   
79.
The canonical explanation for how Jews survived during the Holocaust involves some form of luck. To explore and deepen an understanding of episodic moments of luck, this article presents and discusses survivor Jerry Rawicki's close calls with death during the Holocaust. The first author examines Jerry's perspective as a survivor and her own perspective as a collaborative witness to his stories, as well as how these stories fit together within the broader literature about luck and survival. She suggests possible consequences of regarding luck as the sole explanation of survival and contends that agency and luck can go hand in hand even under oppressive structural conditions, such as the Holocaust. She concludes by reflecting on why Jerry and she might understand survival differently and on the importance of considering both positions in compassionate collaborative research.  相似文献   
80.
Problems in the establishment of the sense of a ‘psychic’ skin, in the ways described by Bick and Meltzer for example, commonly give rise to distortions in the capacity for self‐experiences as a consequence of difficulties in relation to projective and identificatory processes. These latter may acquire a markedly adhesive character as a defence against the anxieties that arise. This makes for considerable technical difficulties in an analysis. This essay addresses the nature of these problems and considers some of the ways in which they may be approached clinically.  相似文献   
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