慢性乙型肝炎的联合抗病毒治疗可以降低核苷类药物的耐药率

慢性乙型肝炎是一种很难治愈的疾病，需要长期治疗以抑制病毒的复制，改善预后。现有的核苷（酸）类药物有较强的抗病毒效果，但在长期治疗过程中，容易发生病毒的耐药突变。多种药物的联合治疗可有效降低核苷（酸）类药物的耐药率，有助于长期治疗。     

The curious case of the refrigerator-TV: similarity and hybridization

This article examines the role of similarity in the hybridization of concepts, focusing on hybrid products as an applied test case. Hybrid concepts found in natural language, such as singer songwriter, typically combine similar concepts, whereas dissimilar concepts rarely form hybrids. The hybridization of dissimilar concepts in products such as jogging shoe mp3 player and refrigerator TV thus poses a challenge for understanding the process of conceptual combination. It is proposed that models of conceptual combination can throw light on the judged future success and desirability of hybrid products in general. The composite prototype model proposes two stages of conceptual combination. In the first stage, the concepts are aggregated into an additive hybrid, simply by forming the union of the two sets of attributes. In the second stage, any conflicting attributes are identified and resolved, often with the introduction of emergent attributes, resulting in an integrative hybrid. Across four studies that varied the similarity and type of hybrid products, similar and integrative hybrids were valued more than dissimilar and additive hybrids. Critically, though, dissimilar hybrids were also highly valued if they were integrative. Results supported the two stages proposed by the composite prototype model, and implications for other models of hybrid formation are discussed.     

Updating: A psychologically basic situation of probability revision

The Bayesian model has been used in psychology as the standard reference for the study of probability revision. In the first part of this paper we show that this traditional choice restricts the scope of the experimental investigation of revision to a stable universe. This is the case of a situation that, technically, is known as focusing. We argue that it is essential for a better understanding of human probability revision to consider another situation called updating (Katsuno & Mendelzon, 1992 Katsuno, A. and Mendelzon, A. 1992. “On the difference between updating a knowledge base and revising it”. In Belief revision, Edited by: Gärdenfors, P. 183–203. Cambridge, , UK: Cambridge University Press. [Crossref] , [Google Scholar]), in which the universe is evolving. In that case the structure of the universe has definitely been transformed and the revision message conveys information on the resulting universe. The second part of the paper presents four experiments based on the Monty Hall puzzle that aim to show that updating is a natural frame for individuals to revise their beliefs.     

Justice and peaceful cooperation

Justice is important, but so is peaceful cooperation. In this article, I argue that if one takes seriously the autonomy of individuals and groups and the fact of moral pluralism, a just system of cooperation cannot guarantee peaceful cooperation in a pluralistic world. As a response to this consideration, I develop a contractarian theory that can secure peace in a pluralistic world of autonomous agents, assuming that the agents who exist in this world expect that peaceful cooperation is the most beneficial form of interaction for them in the long run. The theory specifies the restrictions on the behavior of autonomous individual and collective agents that are indispensable for peaceful cooperation in a pluralistic world. In particular, I argue for the need of (i) a globally valid rule of conflict resolution to settle all intra- and inter-group conflicts that cannot be resolved locally, (ii) a world court to apply this rule in cases where local group authorities are inadequate to do so, and to serve as a final court of appeal, and (iii) a world police to enforce the rule.     

How do we process novel conceptual combinations in context?

Most theories of how people interpret novel noun–noun combinations (e.g., ghost forest) do not sufficiently address the role of context, which is surprising given that novel combinations are generally encountered in discourse contexts. We evaluated three hypotheses for the role of context in interpretation. The generation hypothesis states that interpretation is based on sense generation both in and out of context. The anaphor resolution hypothesis states that interpretation initially involves identifying a referent from the prior discourse context, and meaning generation occurs only if anaphoric processing fails. The dual-process hypothesis states that sense generation and anaphor resolution operate in parallel, and both may influence initial interpretation. In two experiments, we examined reading times on novel combinations when the dominant meaning (most likely interpretation) or subordinate meaning (infrequent interpretation) preceded or followed the combination in text. Results supported the dual-process hypothesis.     

汉语声调远距离规则的内隐学习及其迁移效应

内隐学习研究领域的一个重要问题是内隐学习获得的知识究竟是什么,即内隐学习获得的知识究竟是底层的抽象规则还是表面的特征.研究以汉语声调的远距离水平映射这一远距离规则为材料,通过对表面特征和底层规则之间的分离操作,在控制组块和重复结构等表面特征的条件下,探讨声调远距离规则的习得和迁移,结果发现被试能够内隐地习得和迁移汉语平仄声调的水平映射规则,证实了内隐学习确实能够获得底层的抽象规则,为内隐学习的抽象性问题提供了新的证据.     

How to bring the news … peak-end effects in children’s affective responses to peer assessments of their social behavior

The retrospective evaluation of an event tends to be based on how the experience felt during the most intense moment and the last moment. Two experiments tested whether this so-called peak-end effect influences how primary school students are affected by peer assessments. In both experiments, children (ages 7–12) assessed two classmates on their behaviour in school and then received two manipulated assessments. In Experiment 1 (N ?=?30), one assessment consisted of four negative ratings and the other of four negative ratings with an extra moderately negative rating added to the end. In Experiment 2 (N ?=?44), one assessment consisted of four positive ratings, and the other added an extra moderately positive rating to the end. Consistent with the peak-end effect, the extended assessment in Experiment 1 and the short assessment in Experiment 2 were remembered as more pleasant and less difficult to deal with, which shaped children’s peer assessment preferences and prospective choices of which assessment to repeat. These findings indicate that the process of peer assessment can be improved by ending the feedback with the most positive part of the assessment.     

测验理论的新发展:多维项目反应理论

多维项目反应理论是基于因子分析和单维项目反应理论两大背景下发展起来的一种新型测验理论。根据被试在完成一项任务时多种能力之间是如何相互作用的,多维项目反应模型可以分为补偿性模型和非补偿性模型两类。本文在系统介绍了当前普遍使用的补偿性模型的基础上,指出后续研究者应关注多维项目反应理论中多级评分和高维空间的多维模型、补偿性和非补偿性模型的融合、参数估计程序的开发和多维测验等值四个方面的研究。