The Survivor Health and Resilience Education (SHARE) Program: Development and Evaluation of a Health Behavior Intervention for Adolescent Survivors of Childhood Cancer

Few evidence-based health behavior interventions for adolescent survivors of childhood cancer currently exist. These interventions are necessary to address a range of lifestyle and behavioral factors (e.g., diet and physical activity, tobacco and alcohol use, excessive sun exposure) that may place survivors at increased risk for secondary cancers other chronic diseases. To address this need, the development and evaluation of a health promotion and disease prevention program for childhood cancer survivors is described, with an emphasis on the steps leading up to conducting a randomized controlled trial to test its efficacy. Data gathered from trial participants suggest the preliminary evaluation of the intervention is favorable. Trends and future directions in behavioral intervention research with childhood cancer survivors are discussed, along with the role of behavioral research in health promotion and disease prevention.     

TESTICULAR SELF-EXAMINATION: VALIDATION OF A TRAINING STRATEGY FOR EARLY CANCER DETECTION

Testicular self-examination (TSE) can lead to early diagnosis and treatment of testicular cancer, the third leading cause of death in young men. We evaluated the effectiveness of a brief and specific checklist for teaching TSE skills. Ten men were videotaped while performing testicular self-examinations before and after training. The TSE training resulted in large and significant increases in the number of TSE steps completed and duration of the TSE. Two urological validation measures supported the improvements observed in the mens' self-examinations. Subjects reported continued performance of TSE during a follow-up telephone interview. This pilot study indicates that a brief and specific checklist is an effective strategy for teaching early cancer detection skills.     

雷替曲塞治疗老年晚期结直肠癌的疗效分析

比较雷替曲塞与5-氟尿嘧啶联合奥沙利铂治疗老年晚期结直肠癌的临床疗效及生存分析。经病理明确诊断的老年晚期结直肠癌患者42例分为A、B两组,分别采用雷替曲塞和5-氟尿嘧啶／亚叶酸钙联合奥沙利铂方案化疗,观察两组疗效、不良反应及生存分析。结果A、B两组患者有效率接近,无统计学差异。A、B组疾病进展时间分别是7．5个月和5．...     

广西扶绥肝癌防治引发的环境与健康关系的哲学思考

从分析文献资料入手,对环境与健康的关系进行哲学思考。广西扶绥以玉米为主食的人群,因摄入过量黄曲霉素及饮用污染塘水,导致肝癌高发和高死亡率;而减少黄曲霉素摄入量、改饮清洁水,肝癌发生率和死亡率随之降低。因此,环境与健康相互影响,高温高湿环境诱发玉米产生黄曲霉素,污染塘水存在大量腐殖酸,食之饮之严重危害人的健康;健康意识觉醒,主粮由玉米改为水稻,饮用深井水,健康状况得以改善。在尊重环境与健康相互影响客观性基础上,追求客观性与主观性、人文性的统一。     

Associations of transcranial doppler velocity,age, and gender with cognitive function in children with sickle cell anemia in Nigeria

Children with sickle cell anemia (SCA) have elevated cerebral blood velocity relative to healthy peers. The primary aim of this study was to evaluate the association between cerebral blood velocity, measured by transcranial Doppler (TCD) ultrasound, age, and gender with cognitive function in children with SCA in Nigeria. Eighty-three children (M_age = 9.10, SD = 1.90 years; 55% female) with SCA in Nigeria completed cognitive assessments and a TCD ultrasound. The association between TCD velocity and measures of perceptual reasoning (Raven’s Progressive Matrices), working memory (WISC-IV Digit Span), and executive planning (Tower of London, TOL) were assessed. Results showed that elevated TCD velocity significantly predicted lower scores on TOL Time Violations and Total Problem-Solving Time when controlling for BMI, hemoglobin level, and parent education, suggesting that TCD velocity is related to the efficiency of executive function. Further, age was negatively related to children’s performance on the Ravens Matrices and TOL Total Correct, and boys showed greater deficits on the TOL Total Correct relative to girls. Moderation analyses for gender showed that there was a conditional negative association between TCD velocity and Digit Span for boys, but not for girls. Findings suggest that children with SCA in Nigeria with elevated TCD velocity are at risk for deficits in efficiency of executive planning, and boys with elevated TCD velocity are particularly at increased risk for deficits in auditory working memory. Implications of this study are important for interventions to reduce cerebral blood velocity and the use of TCD in this population.     

Psychological health in long-term cancer survivorship: an Italian survey on depression and anxiety

Since long-term survivorship is now a reality for an increasingly number of people with a history of cancer, understanding their psychological health can inform health care policy as well as help supporting individual patients. This study was aimed to describe depression and anxiety (i.e. two of the most common psychological symptoms reported in oncology) in a sample of Italian long-term cancer survivors (LTCSs) defined as people who have been free from cancer and cancer treatments for at least five years. Four hundred and four Italian adult LTCSs completed a battery of questionnaires including the Zung Self-rating Depression Scale and the State Anxiety sub-scale of the State-Trait Anxiety Inventory respectively for depression and anxiety assessment. 16.5% of the sample displayed mild depression, 11.1% moderate depression, and 7.1% severe depression. depression was negatively associated with education (p = .017), perceived social support as provided by the family (p = .028), and perceived social support provided by friends (p = .008), and it was positively associated with occupational status (p = .023), presence of health issues (p = .010), and anxiety (p < .001). 8.7 and 15.8% of the sample were respectively possible and probable cases of anxiety. Anxiety was negatively associated with occupational status (p = .038) and it was positively associated with depression (p < .001). These data support ongoing assessment and monitoring of depression and anxiety in LTCSs, and stimulate the development and testing of psychological interventions for such individuals. In addition, they encourage further study on the psychological health of this specific population.     

Relationship between religious beliefs and post-traumatic growth in patients with cancer in southeast of Iran

Information about religious beliefs and post-traumatic growth is limited in Iranian cancer patients. This study was conducted to determine the relationship between religious beliefs and post-traumatic growth among cancer patients in Iran. This correlational study included a convenience sample of 200 eligible cancer patients who were hospitalized in the oncology wards and outpatient clinics. Using Post-traumatic Growth Inventory (PTGI) and Religious Beliefs Scale, data were collected. Findings showed that, the total mean score of PTG was 93.81 (SD?=?15.25). Among the categories, the lowest score belonged to “appreciation of life” component (7.67±1.99), and the highest score belonged to “spiritual change” component (67.49 ± 17.78). The mean score of Religious Beliefs Scale was 67.20 (12.35). Post-traumatic growth positively correlated with religious beliefs (r?=?.345; p?=?.001). The results suggest that, information about religious beliefs and post-traumatic growth should be included in the continuous and in-service education of cancer patients and nurses who work with them.     

胞外体认识之新进展

胞外体是由多种细胞分泌的一种膜性小囊泡,参与多种生理及病理生理过程。近年研究发现,由抗原提呈细胞分泌的胞外体富集MHCI/II类分子、协同刺激分子、热休克蛋白70~90等多种生物活性分子于一身,在体内外免疫调节中起关键作用。就胞外体的基本特征及其作为一种新型的亚细胞疫苗在抗肿瘤和抗病毒免疫中的应用前景予以综述。     

人类胚胎干细胞研究伦理问题的调查和讨论

此次对各级医生进行关于人类胚胎干细胞研究伦理认知的调查研究,其目的是为制订相关的伦理准则提供认知依据,调查是在我国东西部二个城市的8家三级医院进行,采用随机抽样、自愿无记名填写信息表方法调查.调查结果表明,50%以上医生认为早期胚胎不是道德意义的人,70%以上医生对胚胎干细胞的研究表示支持.海峡两岸的医生由于有相同的文化根源,在对待胚胎干细胞研究的伦理观点及态度上极其接近.     

异基因造血干细胞移植中的哲学思考

异基因造血干细胞移植(Allo-HSCT)是目前治疗恶性血液病及其它疾病的主要手段之一,它具有自然科学的一般规律,也有其独特性,其中闪烁着哲学智慧的光辉,用哲学的思想来指导工作的进行,能促进Allo-HSCT的不断发展和取得更好的疗效.