探讨人乳头瘤病毒L1蛋白功能及其临床意义

高危型别人乳头瘤病毒（HPV）感染在宫颈癌发生发展中具有重要作用。由于HPV L1蛋白结构特征及其精确的抗原特性,在粘附宿主细胞、识别病毒受体、协助病毒DNA的入胞转运中均发挥重要作用。检测患者宫颈损伤组织中L1蛋白的表达将有助于对患者是否具有传染性进行评估。本文将深刻思考HPV L1功能及其在感染机体并引发癌变的机制,以期更好的解读宫颈癌发病原理并最终应用于,强床治疗。     

CD4＋CD25＋Foxp3＋调节性T细胞与肺癌的临床分期及化疗关系的研究

为了研究Treg与肺癌的临床分期及化疗的关系,分离52例初治肺癌患者化疗前后PBMC,以12例正常者为对照,荧光标记的单抗染色,流式细胞仪检测Treg占CD4＋T细胞的比值。结果显示肺癌患者该比值高于对照组,Ⅲ＋Ⅳ期的高于Ⅰ＋Ⅱ期。化疗疗效（SD＋PD）高于PR。因此,肺癌患者Treg比例较正常人升高,且分期越高该比值增加越明显;疗效差的该比值高于化疗有效病例。推测Treg升高与肺癌的发生、发展有关。     

非小细胞肺癌靶向药物治疗争论热点

非小细胞肺癌作为全球和我国发病率最高、死亡人数最多的恶性肿瘤,其药物治疗始终是临床肿瘤学界高度关注的焦点之一。肿瘤的药物治疗模式从单纯以细胞毒药物杀伤肿瘤逐步向调节信号传导通路转变,分子靶向药物日益成为治疗肿瘤的重要武器。回顾肺癌靶向治疗的进展,诸多问题需要解决。     

血管内皮生长因子与结直肠癌的研究

血管内皮生长因子（vascular endothelial growth factor,VEGF）是一高度特异作用于内皮细胞的糖蛋白,是目前发现的最重要的肿瘤血管生长因子之一。结直肠癌的生长、侵袭和转移与血管内皮生长因子有密切的关系,VEGF在结直肠癌治疗中的作用日益突出。本文就VEGF的功能、在结直肠癌中的表达和治疗的作用作一综述。     

肿瘤标记物在大肠癌临床诊治中的应用进展

总结肿瘤标记物在大肠癌临床诊治中的应用进展。对有关大肠癌临床诊治中肿瘤标记物的文献进行综述,重点讨论血清、基因和急性期蛋白三类标记肿瘤物对大肠癌临床诊治方面的价值和潜力。结果是恰当选择肿瘤标记物有助于大肠癌临床诊治。目前,基因和急性期蛋白为大肠癌肿瘤标记物探索的新方向,有望成为提高大肠癌诊治效率的新检查方法。三类肿瘤标记物对大肠癌诊治有临床意义,联合检测可提高大肠癌诊治的准确性和有效性。     

老年非小细胞肺癌治疗策略

非小细胞肺癌被认为是老年疾病。迄今为止尚无专门针对治疗老年NSCLC的指导原则。作者就当今对老年NSCLC的治疗策略进行论述,并指出年龄不是影响NSCLC患者实施手术治疗、放射治疗以及化学治疗的单一因素。     

血管内皮生长因子与结直肠癌的研究

血管内皮生长因子(vascular endothelial growth factor,VEGF)是一高度特异作用于内皮细胞的糖蛋白,是目前发现的最重要的肿瘤血管生长因子之一.结直肠癌的生长、侵袭和转移与血管内皮生长因子有密切的关系,VEGF在结直肠癌治疗中的作用日益突出.本文就VEGF的功能、在结直肠癌中的表达和治疗的作用作一综述.     

英语文章阅读过程中的文章标记效应研究

该研究通过三个实验探讨高职生英语阅读的文章标记效应。实验一探讨文章标记对阅读英语长、短文章的影响,结果发现文章标记对英语长文章主题信息保持的促进作用大于对英语短文章主题信息的促进作用。实验二以EyelinkⅡ型眼动仪为工具,考察被试阅读有、无标记文章的主题句的眼动模式的差异,结果发现被试阅读这两类主题句的眼动模式存在显著差异。实验三考察对被试进行文章结构策略训练对文章标记效应的影响,结果发现训练促进了被试对无标记英语长文章主题信息的保持,研究结果支持策略转换假设。     

Passing Through the Wall: On Outings,Exodus, Angels,and the Ark

Classicists have argued that angels in Christian theology were modeled on the eunuchs of antiquity; with angels providing the same services to the Lord in Heaven that eunuchs provided to emperors on Earth. I apply this idea toward understanding the cherubim on the ark in Exodus 25 and the death of Aaron’s sons in Leviticus 10. I also suggest that the angel-eunuch analogy can help us understand the psychological impact of androgen deprivation therapy on modern prostate cancer patients. Appreciating this analogy can help prostate cancer patients accept and adapt to the changes they experience.

Imagining the Future of Photoacoustic Mammography

How can a realistic ethical imagination about the future of a technology take shape? This article contains a reflection which is based on the experiences of an embedded ethicist in the context of biophysical research conducive to the development of photoacoustic mammography, which is intended for the non-invasive detection of breast cancer. Imagination in this context already informs the activities of the biophysical researchers, but its role is limited: biophysical future scenarios concentrate on the technological advances that photoacoustics could bring about. In this article it is argued that it is advisable to also consider the medical practice and the ways in which this practice is likely to change as an effect of the introduction of photoacoustic mammography into it. On the basis of this more encompassing imaginative endeavor it is possible to get a clearer idea about how new technologies are able to contribute to human well being, which is informative for the setting of research-goals/priorities and a responsible implementation of new technologies into the world.